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Impact of Granulocyte Colony-Stimulating Factor (G-CSF) on Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation: Does Speeding Up Neutrophil Engraftment Make a Difference? [PDF]

open access: yesTransplant Direct
Alnughmush A   +15 more
europepmc   +1 more source

Different impacts of granulocyte colony-stimulating factor administration on allogeneic hematopoietic cell transplant outcomes for adult acute myeloid leukemia according to graft type. [PDF]

open access: yesAm J Hematol
Konuma T   +24 more
europepmc   +1 more source
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Granulocyte Colony-Stimulating Factor

Southern Medical Journal, 1993
Recombinant human granulocyte colony-stimulating factor (G-CSF) is a nonglycosylated protein produced in Escherichia coli using recombinant DNA technology. G-CSF was first defined in vitro as a relatively selective stimulator of pure granulocyte colonies from normal marrow and as a factor that induces differentiation of leukemic cell lines.
openaire   +3 more sources

Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor

New England Journal of Medicine, 1992
FOUR colony-stimulating factors influence the survival, proliferation, differentiation, and functional activation of myeloid hematopoietic cells: macrophage colony-stimulating factor (M-CSF), granulocyte colony-stimulating factor (G-CSF), granulocytemacrophage colony-stimulating factor (GM-CSF), and interleukin-3 (formerly known as multi-colony ...
Alastair J.J. Wood   +2 more
openaire   +1 more source

Granulocyte-Macrophage Colony-stimulating Factor

Biotherapy, 1990
Publisher Summary Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of the four classical colony-stimulating factors discovered in the 1960s following the introduction of semi-solid bone-marrow culture techniques. The human GM-CSF gene is located on chromosome 5 (q25–q31) within 10 kb of the interleukin-3 (IL-3) gene and in the same ...
S, Devereux, D C, Linch
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Granulocyte Colony-Stimulating Factors

2004
Granulocyte colony-stimulating factor (G-CSF) is a major regulator of the development of antibacterial neutrophilic granulocytic leukocytes (neutrophils). In keeping with the functions of both G-CSF and neutrophils, the murine molecule was first purified from medium that had bathed the dissected lungs of animals previously treated with a bacterial cell-
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The Granulocyte-Macrophage Colony-Stimulating Factors

Science, 1985
The granulocyte-macrophage colony-stimulating factors are well-characterized specific glycoproteins that interact to control the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and monocyte-macrophages.
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Granulocyte colony stimulating factor.

Methods in enzymology, 1986
Granulocyte colony-stimulating factor was discovered during attempts to define the normal regulators present in cell supernatants that could induce terminal differentiation of the murine myeloid leukemic cell line WEHI-3B D+. The purification and subsequent cloning of both murine and human G-CSF allowed the normal functions of this molecule to be ...
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Granulocyte Colony-Stimulating Factor

1990
Neutrophils have a very limited life span and must be replaced constantly by proliferation and differentiation of precursor cells in the bone marrow which become mature blood cells. From studies on the proliferation and differentiation of hematopoietic progenitor cells in vitro in semisolid culture systems (Metcalf 1984) it has become evident that ...
K. Welte, E. Platzer
openaire   +1 more source

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