Results 51 to 60 of about 129,342 (334)

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

In-silico analysis of myeloid cells across the animal kingdom reveals neutrophil evolution by colony-stimulating factors

eLife, 2020
Neutrophils constitute the largest population of phagocytic granulocytes in the blood of mammals. The development and function of neutrophils and monocytes is primarily governed by the granulocyte colony-stimulating factor receptor family (CSF3R/CSF3 ...
Damilola Pinheiro, Marie-Anne Mawhin, Maria Prendecki, Kevin J Woollard   +3 more
doaj   +1 more source

Use of recombinant human granulocyte-macrophage colony stimulating factor in an infant with reticular dysgenesis [PDF]

, 1995
We present the case of a 2-month-old infant with reticular dysgenesis who was treated with recombinant granulocyte-macrophage colony stimulating factor with the aim of stimulating granulopoiesis while awaiting bone marrow ...
Alzina, V. (Valentín), Azcona-San-Julian, M.C. (María Cristina), Barona, P. (Pascual), Sierrasesumaga, L. (Luis), Villa-Elizaga, I. (Ignacio)   +4 more
core  

Red Blood Cell‐Induced Bacterial Margination Improves Microbial Hemoadsorption on Engineered Cell‐Depleted Thrombi, Restoring Severe Bacteremia in Rats

Advanced Science, EarlyView.
A highly efficient extracorporeal device for treating bacteremia is developed by integrating microfluidic bacterial margination and engineered cell‐depleted thrombi strategically constructed in the device. The rodent models, severely infected with antibiotic‐resistant bacteria, recover from bacteremia after two subsequent extracorporeal blood ...
Bong Hwan Jang, Su Hyun Jung, Seyong Kwon, Sung Jin Park, Joo H. Kang   +4 more
wiley   +1 more source

Clozapine-Associated Agranulocytosis Treatment With Granulocyte Colony-Stimulating Factor/Granulocyte-Macrophage Colony-Stimulating Factor [PDF]

Journal of Clinical Psychopharmacology, 2017
Abstract Purpose/Background Clozapine is associated with hematological abnormalities, notably neutropenia, which may progress to agranulocytosis. Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have been used to reduce the frequency and duration of clozapine ...
Lally, John, Malik, Steffi, Whiskey, Eromona, Taylor, David M., Gaughran, Fiona P., Krivoy, Amir, Flanagan, Robert J., Mijovic, Aleksandar, MacCabe, James H.   +8 more
openaire   +5 more sources

Effects of EDTA-Induced Hypocalcaemia and Stress on Plasma TNF-α, IL-1-ra, G-CSF, GM-CSF and S-100 in Dairy Cows [PDF]

, 2018
The pathophysiology of postparturient paresis is still not completely understood. Knowledge recently acquired in immunology, endocrinology and cell physiology has still to be integrated in order to elucidate the aetiopathogenesis of the disease. For that
Döbeli, M., Joller-Jemelka, H.I., Kaiser, C., Liesegang, A., Riond, J.-L, Wanner, M.   +5 more
core  

Neutrophil Macrophage Crosstalk via Extracellular Vesicles Drives Reverse Migration in a Fully Human Model of Wound Healing

Advanced Science, EarlyView.
A novel microphysiological system that can mimic sterile or non‐sterile injury demonstrates that macrophage‐derived extracellular vesicles modulate neutrophil migratory responses to these different wound states. The model showed that resolution of inflammation through neutrophil reverse migration is driven by IL‐8 derived from extracellular vesicles ...
Kehinde Adebayo Babatunde, Oluwadamilola Fatimat Babatunde, Adeel Ahmed, Wilmara Salgado‐Pabon, David J Beebe, Sheena C. Kerr   +5 more
wiley   +1 more source

Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin [PDF]

, 2005
Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis ( RA) by assessing a ...
A Bucht, AN Akbar, AN Akbar, Arne N Akbar, B Relic, BP Leung, C Jakubzick, Caroline Gordon, CD Buckley, CD Buckley, Chi-Yeung Lee, Christopher D Buckley, CM Weyand, D Pilling, DV Jovanovic, E Berglin, Emma J Ross, F Fossiez, F Santiago-Schwarz, FC Arnett, FM Brennan, FP Heinzel, Francesco Falciani, G Husby, G Parsonage, GS Firestein, GS Firestein, GS Firestein, H Visser, HR Schumacher, IB McInnes, J Kaufman, Janet M Lord, JM Bathon, K Raza, Karim Raza, L Breiman, LA Joosten, LJ Zhou, M Boers, M Salmon, M Salmon, M Sebbag, MC Blades, MG Chiaramonte, Mike Salmon, MJ Jacobs, MM Nielen, N Matthews, NJ Zvaifler, P Kurki, P Miossec, PG Conaghan, PK Gregersen, PP Tak, R Bucala, R Gerli, RL Modlin, S John Curnow, SJ Curnow, SK Seo, T Mottonen, T Pap, TF Cox, Y Benjamini, Y Morita   +65 more
core   +2 more sources

Colorectal Cancer Cells–Derived Exosomal PIK3CA Mutation DNA Promotes Tumor Metastasis by Activating Fibroblast and Affecting Tumor Metastatic Microenvironment

Advanced Science, EarlyView.
PIK3CAH1047R DNA in colorectal cancer (CRC) cell‐derived exosomes can be delivered into recipient fibroblasts, where it is transcribed and translated, leading to the activation of fibroblasts into cancer‐associated fibroblasts, which secrete elevated levels of IL6. The simultaneous detection and targeting of PIK3CAH1047R mutation and IL6 may serve as a
Rui Wang, Wanming Li, Yuqiong Lv, Wei Ba, Ying Jiang, Xiaoshuai Li, Jin Fang   +6 more
wiley   +1 more source

Dexamethasone prevents granulocyte-macrophage colony-stimulating factor-induced nuclear factor-κB activation, inducible nitric oxide synthase expression and nitric oxide production in a skin dendritic cell line

Mediators of Inflammation, 2003
Aims: Nitric oxide (NO) has been increasingly implicated in inflammatory skin diseases, namely in allergic contact dermatitis. In this work, we investigated the effect of dexamethasone on NO production induced by the epidermal cytokine granulocyte ...
Ana Luísa Vital, Margarida Gonçalo, M. Teresa Cruz, Américo Figueiredo, Carlos B. Duarte, M. Celeste Lopes   +5 more
doaj   +1 more source