Results 71 to 80 of about 131,866 (237)

Granulocyte-Macrophage Colony-Stimulating Factor as a Therapeutic Target in Multiple Sclerosis

Neurology and Therapy, 2018
Multiple sclerosis is an inflammatory neurodegenerative disease of the central nervous system (CNS) and the most frequent cause of non-traumatic disability in adults in the Western world.
Jehan Aram, Anna Francis, Radu Tanasescu, Cris S. Constantinescu   +3 more
doaj   +1 more source

Lymphoid/nonlymphoid compartmentalization of donor leukocyte chimerism in rat recipients of heart allografts, with or without adjunct bone marrow [PDF]

, 1998
Background. The role of leukocyte migration and chimerism in organ allograft acceptance has been obscured by the lack of information about the late localization of the donor cells. Methods.
Demetris, AJ, Murase, N, Starzl, TE, Terakura, M, Thomson, AW, Ye, Q   +5 more
core   +1 more source

Rescue of myeloid lineage-committed preprogenitor cells from cytomegalovirus-infected bone marrow stroma [PDF]

, 1991
The effect of murine cytomegalovirus on myelopoiesis was studied in long-term bone marrow culture to find an in vitro correlate for the lethal virus interference with bone marrow reconstitution (W. Mutter, M. J. Reddehase, F. W. Busch, H.-J. Bühring, and
Busch, Friedrich W., Koszinowski, Ulrich H., Mutter, Wolfgang, Reddehase, Matthias J.   +3 more
core   +1 more source

Growth of donor-derived dendritic cells from the bone marrow of murine liver auograft recipients in response to granulocyte/macrophage colony-stimulating factor [PDF]

, 1995
Allografts of the liver, which has a comparatively heavy leukocyte content compared with other vascularized organs, are accepted permanently across major histocompatibility complex barriers in many murine strain combinations without immunosuppressive ...
Fu, F, Fung, JJ, Lu, L, McCaslin, D, Qian, S, Rao, AS, Rudert, WA, Starzl, TE, Thomson, AW, Trucco, M   +9 more
core   +1 more source

Lipegfilgrastim in patients with chemotherapy-induced neutropenia

Онкогематология, 2015
The development of dose-limiting toxicities, including myelotoxicity, can significantly limit cytostatic therapy of malignant tumors. Neutropenia associated with high risk of febrile neutropenia (FN) and infectious complications that may interfere with ...
G. D. Petrova, T. Z. Chernyavskaya, N. V. Gorbunova, V. N. Kostrykina, V. A. Doronin, K. N. Melkova   +5 more
doaj   +1 more source

Validation of a new serum granulocyte–macrophage colony-stimulating factor autoantibody testing kit

ERJ Open Research, 2020
Very recently, a modest but significant efficacy of granulocyte–macrophage colony-stimulating factor (GM-CSF) inhalation therapy for the treatment of mild to moderate autoimmune pulmonary alveolar proteinosis (aPAP) has been reported.
Koh Nakata, Tatsuki Sugi, Keiko Kuroda, Kazutaka Yoshizawa, Toshinori Takada, Ryushi Tazawa, Takahiro Ueda, Ami Aoki, Mitsuhiro Abe, Koichiro Tatsumi, Ryosuke Eda, Shotaro Kondoh, Konosuke Morimoto, Takeshi Tanaka, Etsuro Yamaguchi, Ayumu Takahashi, Miku Oda, Haruyuki Ishii, Shinyu Izumi, Haruhito Sugiyama, Atsushi Nakagawa, Keisuke Tomii, Masaru Suzuki, Satoshi Konno, Shinya Ohkouchi, Taizou Hirano, Tomohiro Handa, Toyohiro Hirai, Yoshikazu Inoue, Toru Arai, Katsuaki Asakawa, Takuro Sakagami, Takahiro Tanaka, Ayako Mikami, Nobutaka Kitamura   +34 more
doaj   +1 more source

A Randomised, Blinded, Placebo-Controlled, Dose Escalation Study of the Tolerability and Efficacy of Filgrastim for Haemopoietic Stem Cell Mobilisation in Patients With Severe Active Rheumatoid Arthritis [PDF]

, 1998
Autologous haemopoietic stem cell transplantation (HSCT) represents a potential therapy for severe rheumatoid arthritis (RA). As a prelude to clinical trails, the safety and efficacy of haemopoietic stem cell (HSC) mobilisation required investigation as ...
Biggs, J. C., Brooks, P. M., Fuller, A., Milliken, S. T., Passuello, F., Renwick, J., Snowden, J. A., Staniforth, D.   +7 more
core   +1 more source

Focal Adhesion Kinase and Colony Stimulating Factors: Intestinal Homeostasis and Innate Immunity Crosstalk

Cells
Thousands struggle with acute and chronic intestinal injury due to various causes. Epithelial intestinal healing is dependent on phenotypic transitions to a mobile phenotype.
Nicholas D. Brown, Emilie E. Vomhof-DeKrey   +1 more
doaj   +1 more source

Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF

Haematologica, 2012
Juvenile myelomonocytic leukemia is a lethal disease of children characterized by hypersensitivity of hematopoietic progenitors to granulocyte macrophage-colony stimulating factor.
Charles B. Goodwin, Zhenyun Yang, Fuqin Yin, Menggang Yu, Rebecca J. Chan   +4 more
doaj   +1 more source

CLINICAL USE OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND GRANULOCYTE COLONY-STIMULATING FACTOR IN NEUTROPENIA ASSOCIATED WITH MALIGNANCY

Hematology/Oncology Clinics of North America, 1996
G-CSF and GM-CSF have been shown in each clinical setting to reduce the duration of neutropenia, with the exception of the scant data available in the unrelated bone marrow transplant setting. These growth factors also have been shown to have no leukemogenic effect during the observation periods of the trials discussed.
Robin Lifton, John M. Bennett
openaire   +3 more sources