Macrophage depletion disrupts immune balance and energy homeostasis. [PDF]
, 2014 Increased macrophage infiltration in tissues including white adipose tissue and skeletal muscle has been recognized as a pro-inflammatory factor that impairs insulin sensitivity in obesity.
Feng, Gen-Sheng +4 more
core +2 more sources
Advanced Science, EarlyView.To overcome pancreatic cancer's immunosuppressive barriers, this study explores a dual approach: triggering immunogenic tumor cell death at the primary tumor site with irinotecan‐loaded silicasomes and enhancing immune activation in the spleen using LNPs encapsulating tumor antigen mRNA and a TLR7/8 agonist.
Lijia Luo +3 more
wiley +1 more source
Synthetic peptide epitopes of human granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor [PDF]
, 1988 Colony stimulating factors (CSFs) are a functionally defined class of glycoprotein growth factors that stimulate the proliferation and differentiation of immature precursor cells to mature granulocytes and/or macrophages and have an additional role as ...
Kreisberg, Robert
core +1 more source
The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
Advanced Science, EarlyView.This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen +6 more
wiley +1 more source
Granulocyte-Macrophage Colony-Stimulating Factor as a Therapeutic Target in Multiple Sclerosis
Neurology and Therapy, 2018 Multiple sclerosis is an inflammatory neurodegenerative disease of the central nervous system (CNS) and the most frequent cause of non-traumatic disability in adults in the Western world.
Jehan Aram +3 more
doaj +1 more source
Oral Microbiota and Immune System Crosstalk: A Translational Research
Biology, 2020 Background: Oral pathogens may exert the ability to trigger differently the activation of local macrophage immune responses, for instance Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans induce predominantly pro-inflammatory (M1-like ...
Andrea Ballini +14 more
doaj +1 more source
Interleukin-1 synergizes with granulocyte-macrophage colony-stimulating factor on granulocytic colony formation by intermediate production of granulocyte colony-stimulating factor [PDF]
Blood, 1989 Abstract Interleukin-1 (IL-1) was found to act synergistically with granulocyte- macrophage colony-stimulating factor (GM-CSF) on granulocytic colony growth of normal human bone marrow cells, depleted of mononuclear phagocytes and T lymphocytes.
R. Willemze +6 more
openaire +4 more sources
Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2. [PDF]
, 2017 Human in vitro generated monocyte-derived dendritic cells (moDCs) and macrophages are used clinically, e.g., to induce immunity against cancer. However, their physiological counterparts, ontogeny, transcriptional regulation, and heterogeneity remains ...
Aschenbrenner, Anna C +37 more
core +1 more source
Amplifying Anti‐Tumor Immune Responses via Mitochondria‐Targeting Near‐Infrared Photodynamic Therapy
Advanced Science, EarlyView.Interfacial Nd3+‐triplet energy transfer enables direct activation of molecular triplets under near‐infrared (NIR) irradiation for reactive oxygen species (ROS) generation. Photodynamic therapy (PDT) exaggerates hypoxia, which initiates subsequent hypoxia‐activated chemotherapy.
Cheng‐Ao Li +13 more
wiley +1 more source
Respiratory Medicine Case Reports, 2018 Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare parenchymal lung disease characterized by accumulation of surfactant in the airways with high levels of granulocyte-macrophage colony stimulating factor (GM-CSF) antibodies in blood.
Marta E. Gajewska +3 more
doaj