Results 141 to 150 of about 106,660 (298)
Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models
Arthritis &Rheumatology, EarlyView.Objective Dysregulated type I interferon (IFN) signaling contributes to autoimmune myositis pathogenesis. We investigated the therapeutic effects of JAK inhibitors in two mouse models. We also examined how type I IFNs affect muscle vasculature. Methods Myositis was induced in major histocompatibility complex class I double transgenic ([TRE‐H‐2Kb (H ...
Rita Spathis +11 more
wiley +1 more source
Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis
Arthritis &Rheumatology, EarlyView.Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith +23 more
wiley +1 more source
The redistribution of granulocytes following E. coli endotoxin induced sepsis
, 1994 Infusion of endotoxin elicits granulocytopenia followed by increased numbers of granulocytes in peripheral blood. The purpose of this study was to investigate the redistribution and sequestration of granulocytes in the tissues following E. coli endotoxin
Rasmussen, J W +4 more
core
Arthritis &Rheumatology, EarlyView.Objective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Shuichiro Nakabo +9 more
wiley +1 more source
The Inflammatory Process in Response to Nanoparticles
The Scientific World Journal, 2011 David M. Goncalves +2 more
doaj +1 more source
Effects of Shiga toxin 2 on isolated porcine granulocytes
, 2009 Shiga toxin (Stx) binding to polymorphonuclear neutrophils (PMN) is hypothesized to play a role in the pathogenesis of Shiga toxin-producing Escherichia coli (STEC) disease in humans.
Scherer, Amanda
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi +9 more
wiley +1 more source
Editorial: Molecular mechanisms regulating phenotypic heterogeneity in human inflammatory diseases
Frontiers in Immunology, 2023 Theodore S. Kapellos +2 more
doaj +1 more source
Analysis of CEACAM8 released by stimulated human granulocytes.
, 2014 (a) In all experiments granulocytes were pre-incubated using 50 ng/ml GM-CSF for 90 min. Expression of CD62L on human granulocytes was assessed by FACS analysis after treatment with 20 ng/ml PMA for 1 h.
Bernhard B. Singer (316512) +10 more
core +1 more source
T cells, the Next Big Target in Axial Spondyloarthritis?
Arthritis &Rheumatology, EarlyView.Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley +1 more source