Results 21 to 30 of about 114,052 (250)

Effects of Monomethylfumarate on Human Granulocytes [PDF]

, 1993
Monomethylfumarate (MMF) is the most active metabolite of the new antipsoriasis drug Fumaderm. Because granulocytes play an important role in the pathophysiology of psoriasis, the effects of this drug on the functional activities of these cells were ...
Bezemer, Anja C., van Furth, Ralph, Thio, Bing, Beijersbergen, Roderick L., Nibbering, Peter H., Zomerdijk, Timo P.L.   +5 more
core   +1 more source

Decreased expression of FcγRIII mRNA in leukemic granulocytes [PDF]

, 1992
Morphologically mature granulocytes from patients with chronic myeloid leukemia show significant impairment in their ability to internalize aggregated IgG, a ligand that is rapidly phagocytosed by normal human granulocytes.
Suresh Advani, Monteiro, Joanita, Surekha Zingde, Gothoskar, Balwant, Balwant Gothoskar, Zingde, Surekha, Advani, Suresh, Joanita Monteiro   +7 more
core   +1 more source

Trajectories of human granulocytes [PDF]

, 1979
The spatial trajectories of human granulocytes moving on glass in two dimensions under an isotropic medium may be characterized as realizations of a correlated walk. The present model is similar to an earlier one for slime-mold amebae.
Hall, R.L., Peterson, S.C.
core   +1 more source

CD18 expression in granulocytes infiltrating the vitreous fluid in patients with diabetic retinopathy [PDF]

International Journal of Ophthalmology, 2015
AIM: To assess the levels of CD18 on the surface of granulocytes infiltrating the vitreous fluid in patients with diabetic retinopathy (DR).METHODS:Vitreous samples from twelve patients with non-proliferative DR with significant macula edema (group A ...
Qi Zhu, Hu-Ping Song
doaj   +1 more source

The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions

Frontiers in Immunology, 2018
The adhesion family of G protein-coupled receptors (aGPCRs) comprises 33 members in human, several of which are distinctly expressed and functionally involved in polymorphonuclear cells (PMNs).
Cheng-Chih Hsiao, Tai-Ying Chu, Chia-Jung Wu, Maartje van den Biggelaar, Caroline Pabst, Josée Hébert, Josée Hébert, Taco W. Kuijpers, Taco W. Kuijpers, Brendon P. Scicluna, Brendon P. Scicluna, Kuan-Yu I, Tse-Ching Chen, Ines Liebscher, Jörg Hamann, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin   +17 more
doaj   +1 more source

Influence of granulocytes on brain edema, intracranial pressure, and cerebrospinal fluid concentrations of lactate and protein in experimental meningitis [PDF]

, 1988
Brain water content (brain edema), intracranial pressure, and cerebrospinal fluid (CSF) concentrations of lactate and protein increased significantly during 24 h of experimental meningitis due to Streptococcus pneumoniae, but changes were similar in ...
M. G. Tauber, Borschberg, U, M. A. Sande, Täuber, MG, Tauber, M G, U. Borschberg, Sande, M A, Sande, MA   +7 more
core   +1 more source

Neutralizing serum IgE upregulates CD88 and CRTH2 expression on basophils in patients with asthma

Journal of Allergy and Clinical Immunology: Global
Background: The cross-linking of FcεRI by IgE and allergen leads to the degranulation of basophils and mast cells, which can drive allergic reactions. Neutralizing IgE with omalizumab could thus offer clinical benefits to a subset of patients with asthma.
Agnes Yang, BS, Laurie Baert, PhD, Katherine Upchurch, PhD, Matthew Wiest, PhD, Jacob Turner, PhD, HyeMee Joo, PhD, Mark Millard, MD, SangKon Oh, PhD   +7 more
doaj   +1 more source

MST1 controls murine neutrophil homeostasis via the G-CSFR/STAT3 axis

Frontiers in Immunology, 2022
The release of neutrophils from the bone marrow into the blood circulation is essential for neutrophil homeostasis and the protection of the organism from invading microorganisms. Granulocyte colony-stimulating factor (G-CSF) plays a pivotal role in this
Sergi Masgrau-Alsina, Lou Martha Wackerbarth, Dae-sik Lim, Markus Sperandio   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Whole-blood model reveals granulocytes as key sites of dengue virus propagation, expanding understanding of disease pathogenesis

mBio
Dengue virus (DENV) infection poses a significant global health threat, yet our understanding of its immunopathogenesis remains incomplete due to limitations of existing models.
Hansa Praneechit, Somchai Thiemmeca, Dararat Prayongkul, Kessiri Kongmanas, Dumrong Mairiang, Nuntaya Punyadee, Adisak Songjaeng, Nattaya Tangthawornchaikul, Nasikarn Angkasekwinai, Kanokwan Sriruksa, Yupin Suputtamongkol, Wannee Limpitikul, John P. Atkinson, Panisadee Avirutnan   +13 more
doaj   +1 more source