Results 21 to 30 of about 92,038 (266)

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Granuloma whorls [PDF]

Clinical Case Reports, 2019
AbstractWhat is the significance of bone marrow examination in presence of peripheral cytopenias? It is still regarded as a mandatory investigation to diagnose hematological disorders. In this case, bone marrow trephine was initially done as a diagnosis of exclusion for ITP, whereas it revealed multiple granulomas suggesting mycobacterium tuberculosis ...
Farrukh Zia, Natasha Ali
openaire   +3 more sources

TREATMENT EXPERIENCE OF PATIENTS WITH LARYNGEAL GRANULOMA USING HIGH-ENERGY SURGICAL EQUIPMENT ENT

Медицинский совет, 2017
Contact  vocal process granuloma causative factors are gastroesophageal  reflux, intubation trauma, and vocal abuse  and psychosomatics. Treatment includes proton pump inhibitors, voice therapy, psychotherapy and surgical excision  in case of ...
V. M. Svistushkin, S. V. Starostina, E. B. Rakunova   +2 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Matrix Metalloproteinase-12 Is Required for Granuloma Progression

Frontiers in Immunology, 2020
BackgroundSarcoidosis is a chronic inflammatory disease of unknown cause characterized by granuloma formation. Mechanisms for chronic persistence of granulomas are unknown.
Arjun Mohan, Nicole Neequaye, Anagha Malur, Eman Soliman, Eman Soliman, Matthew McPeek, Nancy Leffler, David Ogburn, Debra A. Tokarz, Warren Knudson, Sina A. Gharib, Lynn M. Schnapp, Barbara P. Barna, Mary Jane Thomassen   +13 more
doaj   +1 more source

T Cell Interactions in Mycobacterial Granulomas: Non-Specific T Cells Regulate Mycobacteria-Specific T Cells in Granulomatous Lesions

Cells, 2021
Infections with pathogenic mycobacteria are controlled by the formation of a unique structure known as a granuloma. The granuloma represents a host–pathogen interface where bacteria are killed and confined by the host response, but also where bacteria ...
Dominic O. Co, Laura H. Hogan, Jozsef Karman, Melinda Herbath, Zsuzsanna Fabry, Matyas Sandor   +5 more
doaj   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Synthetic O‐Polysaccharide Backbone Units for a Single Antigen Vaccine Against Two Major Non‐Typhoidal Salmonella Serovars

Angewandte Chemie, EarlyView.
A modular strategy was developed to synthesize tri‐, hexa‐, and nona‐saccharides representing repeating units of the conserved O‐polysaccharide backbone of Salmonella. Conjugates of these glycans to bacteriophage Qβ induced strong IgG responses in mice and rabbits. Antibodies elicited recognized native O‐polysaccharides and conferred protection against
Xingling Pan, Changxin Huo, Soham Maity, Herbert Kavunja, Rachel Moszyk, Cameron Talbot, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +2 more sources

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Diagnosis of anxiety-depression disorders in patients with laryngeal granuloma [PDF]

Наука и инновации в медицине, 2020
Objectives - to determine the variants of psychiatric disorders in patients with laryngeal granuloma using the affectivity-stress model, based on the complex psychopathological and clinical-psychological diagnostics of anxiety-depression disorders (ADD).
Andrey I. Kryukov, Dmitriy Yu. Veltischev, Artur E. Zeltyn, Olga F. Seravina, Svetlana G. Romanenko, Elena A. Teplykh   +5 more
doaj   +1 more source