Results 71 to 80 of about 21,129 (222)

Wegener-granulomatosis [PDF]

, 2015
A Wegener-granulomatosis a kis és közepes átmérőjű erek granulomaképződéssel járó nekrotizáló gyulladása. Súlyosság és klinikai megjelenés szempontjából a betegség igen széles skálát mutat.
Csákó László,, Domján, Gyula, Gadó, Klára, Z Szabó László,   +3 more
core   +1 more source

The Effect of Intranasal Niclosamide on Nasal Symptoms in Patients with Anti‐Neutrophil Cytoplasmic Antibody‐Associated Vasculitis

Arthritis &Rheumatology, Accepted Article.
Objective Ear, nose and throat (ENT) manifestations are common in ANCA‐associated vasculitis (AAV). There is unmet need for drugs to target these manifestations. Granuloma formation is characteristic of proteinase 3 (PR3)‐AAV. In a zebrafish model, niclosamide inhibits PR3‐induced granuloma formation.
Benjamin Lim, Wendi Qian, Francis Dowling, Alan Salama, Rona Smith   +4 more
wiley   +1 more source

A case of repetitive myocardial infarction with unobstructed coronaries due to Churg-Strauss syndrome [PDF]

, 2019
© The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.BackgroundMyocardial infarction is most commonly caused by thrombosis occurring on a background of coronary atherosclerosis, resulting in reduced ...
Agewall, Benallegue, Dennert, Fatima, Grodzinsky, Groh, Lanham, Masi, Mukhtyar, Takagi, Tornvall, Trivedi   +11 more
core   +3 more sources

Prediction of Relapse and Glucocorticoid Dependence in Eosinophilic Granulomatosis with Polyangiitis: Findings from a Large European Cohort

Arthritis &Rheumatology, Accepted Article.
Background Eosinophilic granulomatosis with polyangiitis (EGPA) is a small vessel vasculitis characterized by eosinophilia, asthma, and ear, nose, throat (ENT) involvement. Although glucocorticoids (GCs) are effective in controlling symptoms, relapses and GC dependence are common.
Matthias Papo, Pauline Martinot, Renato A. Sinico, Vítor Silvestre‐Teixeira, Nils Venhoff, Maria‐Letizia Urban, Michele Iudici, Juliane Mahrhold, Francesco Locatelli, Giulia Cassone, Franco Schiavon, Benjamin Seeliger, Thomas Neumann, Claudia Feder, Matthieu Groh, Chiara Marvisi, Maxime Samson, Thomas Barba, David Jayne, Arianna Troilo, Jens Thiel, Bernhard Hellmich, Sara Monti, Carlomaurizio Montecucco, Carlo Salvarani, Jean‐Emmanuel Kahn, Bernard Bonnotte, Cécile‐Audrey Durel, Xavier Puéchal, Luc Mouthon, Loïc Guillevin, Giacomo Emmi, Augusto Vaglio, Raphaël Porcher, Benjamin Terrier, The French Vasculitis Study Group and the EGPA European Study Group   +35 more
wiley   +1 more source

ANCA-negative Granulomatosis with Polyangiitis: A Difficult Diagnosis [PDF]

, 2017
Granulomatosis with polyangitiis (GPA) is a systemic small and medium vessel vasculitis, commonly associated with anti-neutrophil cytoplasmic antibodies (ANCAs).
McCarthy, Eilis, Mustafa, Muneeb, Watts, Mike   +2 more
core   +2 more sources

Interstitial Lung Disease in ANCA‐Associated Vasculitis: A European Multicentre Study

Arthritis &Rheumatology, Accepted Article.
Background Interstitial Lung Disease (ILD) can occur in association with ANCA‐associated Vasculitis (AAV‐ILD) or as an isolated entity with positive ANCA (ANCA‐ILD). However, data on the epidemiology and outcomes of these conditions remain limited.
Aglaia Chalkia, Marusa Kotnik, Timothy J Sadler, Spyridon Katechis, Rachel Jones, Ajay Kamath, Aladdin J Mohammad, Sara Monti, Chetan Mukhtyar, Viral Nanda, Ioannis Petrakis, Dimitrios Petras, Ashnish Sinha, Pasupathy Sivasothy, Rona Smith, Kostas Stylianou, Dimitrios Vassilopoulos, Judith Babar, David Jayne   +18 more
wiley   +1 more source

Differential diagnosis of granulomatous lung disease: clues and pitfalls

European Respiratory Review, 2017
Granulomatous lung diseases are a heterogeneous group of disorders that have a wide spectrum of pathologies with variable clinical manifestations and outcomes.
Shinichiro Ohshimo, Josune Guzman, Ulrich Costabel, Francesco Bonella   +3 more
doaj   +1 more source

Infliximab therapy of relapsing tracheal stenosis in a pediatric patient with granulomatosis with polyangiitis: a case report

Journal of Medical Case Reports, 2022
Background Granulomatosis with polyangiitis is a granulomatous, necrotizing small-vessel vasculitis affecting both children and adults. However, subglottic tracheal stenosis appears more frequently in the pediatric cohort.
Alexander Schnell, Renate Ruppel, Christina Tremel, Matthias Galiano, Maria-Elena Meßbacher, Tobias Krickau   +5 more
doaj   +1 more source

Straight to Phase III: Model‐Informed Approach Speeds Depemokimab Clinical Development in Interleukin‐5‐Driven Diseases

Clinical Pharmacology &Therapeutics, EarlyView.
Straight to Phase III: Model‐informed approach speeds depemokimab clinical development in interleukin‐5‐driven diseases. IL‐5, a key mediator of type 2 inflammation, underlies various diseases, including severe asthma, CRSwNP, EGPA, and HES. Reduction in blood eosinophil count (BEC), a biomarker of IL‐5 activity, is commonly used to evaluate the ...
Chiara Zecchin, Stein Schalkwijk, Isabelle J. Pouliquen, Alienor Berges, Nicholas Bird, Richard Follows, Daren Austin   +6 more
wiley   +1 more source

Vasculitides associated with IgG antineutrophil cytoplasmic autoantibodies in childhood [PDF]

, 2018
Immunoglobulin (Ig)G antineutrophil cytoplasmic autoantibodies are causally associated with necrotizing vasculitides that are characterized immunopathologically by little or no deposition of immunoreactants, such as Wegener granulomatosis, microscopic ...
Bettinelli, Alberto, Bianchetti, Mario, Keller, Franco, Simonetti, Giacomo, Vanoni, Federica   +4 more
core