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Aspergillosis in Chronic Granulomatous Disease [PDF]
Patients with chronic granulomatous disease (CGD) have the highest life-time incidence of invasive aspergillosis and despite the availability of antifungal prophylaxis, infections by Aspergillus species remain the single most common infectious cause of ...
Jill King+2 more
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Chronic Granulomatous Disease [PDF]
Chronic Granulomatous Disease (CGD) is an inherited immunodeficiency disorder characterized by defective functioning of NADPH oxidase enzyme in the phagocytes.
Shreya Agarwal
doaj +9 more sources
Chronic granulomatous disease: the European experience. [PDF]
CGD is an immunodeficiency caused by deletions or mutations in genes that encode subunits of the leukocyte NADPH oxidase complex. Normally, assembly of the NADPH oxidase complex in phagosomes of certain phagocytic cells leads to a "respiratory burst ...
J Merlijn van den Berg+18 more
doaj +16 more sources
Inherited p40phox deficiency differs from classic chronic granulomatous disease [PDF]
Biallelic loss-of-function (LOF) mutations of the NCF4 gene, encoding the p40phox subunit of the phagocyte NADPH oxidase, have been described in only 1 patient. We report on 24 p40phox-deficient patients from 12 additional families in 8 countries.
Dinauer, Mary C, et al,
core +3 more sources
Cellular Therapies in Chronic Granulomatous Disease
Allogeneic hematopoietic stem cell transplantation (HSCT) has become the main curative treatment in patients with chronic granulomatous disease (CGD). CGD is caused by inherited defects of the phagolysomal NADPH-oxidase, leading to a lifelong propensity ...
Tayfun Güngör, Robert Chiesa
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Chronic granulomatous inflammation caused by latent tuberculosis presented as a subcutaneous mass: A case report with review of literature. [PDF]
Chronic granulomatous inflammation is a global disease caused by infection, auto-immune disease, toxic, or idiopathic factors. Pathological finding shows formation of distinct granulomas composed of aggregates of epithelioid macrophages, with a ...
Yang HG, Kim J, Kim JH.
europepmc +2 more sources
Recent advances in chronic granulomatous disease
Chronic granulomatous disease (CGD) is an inherited defect of phagocyte function due to defective NADPH oxidase. Patients with CGD are not able to effectively clear the infections because of the defect in the phagocyte production of oxygen free radicals ...
Gummadi Anjani+6 more
doaj +2 more sources
Chronic granulomatous Disease (CGD) is a rare innate immunodeficiency disorder caused by mutations in one of the six genes (CYBA, CYBB, NCF1, NCF2, NCF4, and CYBC1/EROS) encoding the superoxide-producing nicotinamide adenine dinucleotide phosphate (NADPH)
Faris Ghalib Bakri+20 more
doaj +1 more source
A case of chronic granulomatous disease and acne: is isotretinoin a safe treatment?
We report the case of a patient with chronic granulomatous disease and acne treated with isotretinoin, who developed a diffuse staphylococcal skin infection during the therapy. Chronic granulomatous disease is a rare genetic disorder characterized by an
Marco Brusasco+2 more
doaj +1 more source
Common variable immune deficiency (CVID) is a primary immunodeficiency syndrome, characterized by a defective B cell function. Although there is no age or gender predilection, it is usually diagnosed between the second and fourth decades of life.
Veena Shamsudeen+4 more
semanticscholar +1 more source