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Chronic granulomatous disease [PDF]
British Medical Bulletin, 2016 Chronic granulomatous disease is a clinical condition that stems from inactivating mutations in NOX2 and its auxiliary proteins. Together, these proteins form the phagocyte NADPH oxidase enzyme that generates superoxide. Superoxide (O2ċ-) and its reduced product hydrogen peroxide (H2O2) give rise to several additional reactive oxygen species (ROS ...
Amit, Rawat +2 more
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Chronic granulomatous disease [PDF]
The British Journal of Radiology, 1970 Abstract Chronic granulomatous disease is a hereditable disorder in which polymorphs show diminished capacity for killing bacteria. Defective bactericidal activity results in protracted infection. The lesions of chronic granulomatous disease may affect all systems of the body.
J, Sutcliffe, A R, Chrispin
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Indian Dermatology Online Journal, 2015 Chronic Granulomatous Disease (CGD) is an inherited immunodeficiency disorder characterized by defective functioning of NADPH oxidase enzyme in the phagocytes. This leads to recurrent infections by catalase positive organisms and later, granuloma formation in multiple organs.
Kikkeri Narayanasetty Naveen +1 more
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Hematology/Oncology Clinics of North America, 2009 Chronic granulomatous disease (CGD) was first described in the 1950s and has become a paradigm for genetic neutrophil diseases. It is characterized by recurrent infections with a narrow spectrum of bacteria and fungi as well as a common set of inflammatory complications most notably including inflammatory bowel disease. Over the last half century major
B H, Segal, L, Romani, P, Puccetti
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Chronic granulomatous disease [PDF]
Clinical and Experimental Immunology, 2000 A clinical syndrome characterized by recurrent life-threatening Staphylococcus aureus, Proteus or Pseudomonas, hypergammaglobulinaemia, and widespread chronic granulomatous infiltration was first recognized in the paediatric literature between 1954 and 1960 [1–3].
D, Goldblatt, A J, Thrasher
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Indian Journal of Dermatology, Venereology and Leprology, 2005 A 2(1/2)-year-old child presented with multiple discrete granulomatous lesions on the face and flexural regions since the age of 2 months along with lymphadenopathy. The patient also had recurrent bouts of pyodermas and respiratory tract infections.
Pradeep S, Nair +4 more
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Aspergillosis in Chronic Granulomatous Disease [PDF]
Journal of Fungi, 2016 Patients with chronic granulomatous disease (CGD) have the highest life-time incidence of invasive aspergillosis and despite the availability of antifungal prophylaxis, infections by Aspergillus species remain the single most common infectious cause of death in CGD.
King, Jill +2 more
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Colitis in chronic granulomatous disease [PDF]
Archives of Disease in Childhood, 2001 Involvement of the gut in chronic granulomatous disease (CGD) has been previously described and colitis highlighted. However, the nature and histopathology of the colitis are unclear and have been thought to be non-specific or similar to Crohn's disease.Seven patients with CGD, suffering from gastrointestinal symptoms were prospectively studied.All ...
M G, Schäppi +4 more
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A Review of Chronic Granulomatous Disease [PDF]
Advances in Therapy, 2017 Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in any of the five subunits of the NADPH oxidase complex responsible for the respiratory burst in phagocytic leukocytes. Patients with CGD are at increased risk of life-threatening infections with catalase-positive bacteria and fungi and inflammatory complications such ...
Arnold, Danielle E. +1 more
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