Results 31 to 40 of about 5,872,109 (287)
Cellular Therapies in Chronic Granulomatous Disease
Frontiers in Pediatrics, 2020 Allogeneic hematopoietic stem cell transplantation (HSCT) has become the main curative treatment in patients with chronic granulomatous disease (CGD). CGD is caused by inherited defects of the phagolysomal NADPH-oxidase, leading to a lifelong propensity ...
Tayfun Güngör, Robert Chiesa
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Cellular and Molecular Life Sciences, 2009 Chronic granulomatous disease is an inherited disorder of the NADPH oxidase characterized by severe bacterial and fungal infections and disordered inflammation. We propose that NADPH oxidase has a key role in regulating acute neutrophilic and T cell responses, which in turn restrains fungal growth and calibrates the inflammatory response to minimize ...
B H, Segal, L, Romani, P, Puccetti
openaire +5 more sources
Chronic granulomatous disease: why an inflammatory disease?
Brazilian Journal of Medical and Biological Research, 2014 Chronic granulomatous disease is a primary immunodeficiency caused by mutations in the genes encoding subunits of the phagocytic NADPH oxidase system. Patients can present with severe, recurrent infections and noninfectious conditions.
P. Roxo-Junior, H.M.L. Simão
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Recent advances in chronic granulomatous disease
Genes and Diseases, 2020 Chronic granulomatous disease (CGD) is an inherited defect of phagocyte function due to defective NADPH oxidase. Patients with CGD are not able to effectively clear the infections because of the defect in the phagocyte production of oxygen free radicals ...
Gummadi Anjani +6 more
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Frontiers in Medicine, 2021 Uveitis associated with Vogt-Koyanagi-Harada (VKH) disease is a bilateral, chronic, granulomatous autoimmune disease associated with vitiligo, poliosis, alopecia, and meningeal and auditory manifestations.
Ahmed M. Abu El-Asrar +4 more
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Methylotroph Infections and Chronic Granulomatous Disease
Emerging Infectious Diseases, 2016 Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by a defect in production of phagocyte-derived reactive oxygen species, which leads to recurrent infections with a characteristic group of pathogens not previously known to include ...
E. Liana Falcone +12 more
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Atypical Presentation of Chronic Granulomatous Disease in a Child
Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche, 2017 Chronic granulomatous disease is a rare, inherited immunodeficiency caused by deletions or mutations in genes that encode subunits of the NADPH oxidase complex. The pattern of chronic granulomatous disease inheritance can be X-linked (about 70% of cases)
Chiara Cuzzupè +7 more
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Preventing Chronic Disease [PDF]
Preventing Chronic Disease (PCD) had its most successful year to date in 2021. Despite the challenges of working during the pandemic, PCD published 4 important collections, published the most widely read article in its history, and continued to appoint ...
core +3 more sources
Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development
Advanced Healthcare Materials, EarlyView.LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans +7 more
wiley +1 more source
Granulomatous Cheilitis and Crohn's Disease
Canadian Journal of Gastroenterology, 2001 Granulomatous cheilitis is characterized by recurrent swelling of the labial tissues and granulomatous histology. Granulomatous cheilitis has been recognized as an early manifestation of Crohn's disease.
Ishfaq Ahmad, David Owens
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