Results 111 to 120 of about 41,908 (249)

Spermatogenesis and sertoli cell activity in mice lacking Sertoli cell receptors for follicle stimulating hormone and androgen [PDF]

, 2008
Spermatogenesis in the adult male depends on the action of FSH and androgen. Ablation of either hormone has deleterious effects on Sertoli cell function and the progression of germ cells through spermatogenesis.
Baker, P.J., Guillou, F., Abel, M.H., Verhoeven, G., De Gendt, K., Guillou, Florian Jean Louis, Charlton, H.M., Monteiro, A., O'Shaughnessy, P.J.   +8 more
core   +1 more source

Mechanism and Intervention of the NPY1R/CREB Signaling Axis in Regulating Inflammatory Response in Aged Ovarian Granulosa Cells and Ovarian Senescence

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Aging‐associated upregulation of NPY1R drives p‐CREB activation, triggering inflammation, mitochondrial dysfunction, and extracellular matrix imbalance to promote ovarian senescence. Pharmacological inhibition of NPY1R with BIBO 3304 restores ovarian homeostasis, highlighting a therapeutic strategy for reproductive aging. ABSTRACT Ovarian senescence is
Junnan Fang, Chaoying Wang, Shuaishuai Guo, Yiping Zhang, Yang Zhang, Huihui Wang, Yue Kong, Haixia Jin, Lin Qi, Yan Liu, Zhaoting Wu, Fuli Zhang, Shuang Wen, Xiaopeng Wang, Guang Yang, Guidong Yao   +15 more
wiley   +1 more source

Case series of rare ovarian malignancy: granulosa cell tumor

, 2017
Granulosa cell tumors are rare ovarian sex cord stromal tumors characterized by indolent course and favorable prognosis. The treatment of granulosa cell tumor is individualized based on many factors like age, desire for future fertility and stage of the ...
Palanivelu Chinnusamy, Devi Balasubramaniam, Barnwal, Rashmi, Kavitha Yogini Duraisamy, Balasubramaniam, Devi, Rashmi Barnwal, Chinnusamy, Palanivelu, Duraisamy, Kavitha Yogini   +7 more
core   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, Volume 13, Issue 32, 9 June 2026.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Gonadal Histology and Spawning Season of Otolithoides pama in the Thanlwin River Estuary

Aquaculture, Fish and Fisheries, Volume 6, Issue 3, June 2026.
ABSTRACT The spawning season of Otolithoides pama in the Thanlwin estuary was estimated through gonadosomatic index (GSI) and histological analyses of gonadal development. A total of 290 specimens (240 females and 50 males) were collected monthly from 5 sites—Ahlat, Kyauk Tan, Daye, Nyaung Pin Seik and Tarana—between January and December 2024.
Thet Htwe Aung
wiley   +1 more source

Docetaxel‐Induced Serositis Mimicking Malignant Pleural Effusion

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Pleural effusions are common in patients with cancer. Although their development may signal progressive malignant disease, drug‐induced effusions are a rare and often overlooked cause of exudative pleural effusions. We describe a 50‐year‐old woman with recurrent granulosa cell tumor of the ovary who developed bilateral pleural and pericardial ...
Muhammad Anees, Kevin Chiu, Stephen Goertzen, Carlos A. Jimenez, Saadia A. Faiz   +4 more
wiley   +1 more source

Bilateral Gonadoblastoma in a 12‐Year‐Old Girl 4 Years After Wilms' Tumor: A Rare Pediatric Case

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT This case of a 12‐year‐old patient who developed bilateral gonadoblastoma 4 years after treatment for Wilms tumor highlights the importance of rigorous, risk‐adapted long‐term surveillance and careful evaluation of incidental gonadal findings, even in asymptomatic patients.
Ahmed Quraish, Hasan Khouli, Yousef Daraghmeh, Sultan Mosleh, Samer Bustame   +4 more
wiley   +1 more source

Characterization of an immortalized human granulosa cell line (COV434) [PDF]

, 2017
We have investigated the biological characteristics of an immortalized granulosa cell line (COV434), which may be used to study follicular and oocyte maturation in vitro. Granulosa cell function was defined as consisting of three distinct properties: (i)
Miny, Peter, Guggenheim, Richard, Litzistorf, Yvonne, Ladewig, Ariane, Zhang, Hong, Dürrenberger, Markus, Holzgreve, Wolfgang, De Geyter, Christian, Vollmer, Marielle, De Geyter, Maria   +9 more
core  

Effects of Total Flavonoids From Rubus chingii Hu on the Hypothalamic–Pituitary–Ovarian Axis and Inflammatory Response in Polycystic Ovary Syndrome Rats

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
RHF improves sex hormone secretion imbalance, restores the estrous cycle, inhibits ovarian hyperplasia and pathology, and reduces systemic and local ovarian inflammation in PCOS rats via enhancing HPO axis function and suppressing NLRP3 inflammasome signaling pathway activation.
Mengfan Peng, Baosong Liu, Lanyue Cao, Chuan Rao, Yingying Sun, Caixia Li, Hao Chen, Lei Yang   +7 more
wiley   +1 more source

Delayed menopause due to granulosa cell tumor of the ovary

, 2011
A 52-year-old patient presented with complaints of menorrhagia. Endometrial biopsy revealed simple hyperplasia of the endometrium. Total abdominal hysterectomy with bilateral oophorectomy was carried out.
Trupti Nadkarni, M J Jassawalla, MJ Jassawalla, Sarita Bhalerao, Bhushan Murkey   +4 more
core   +1 more source