Results 81 to 90 of about 1,700,060 (216)

Therapeutic Potential of Chickpea‐Derived Bioactives: A Review With Perspective of Different In Vitro, Animal, and Human Studies

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT Chickpea (Cicer arietinum L.) is an important dietary legume worldwide and provides micronutrients and phytochemicals, including phenolics, flavonoids, carotenoids, bioactive peptides, dietary fiber, and resistant starch. This narrative review summarizes evidence from in vitro, animal, and human studies on the potential health relevance of ...
Rohama Shahid, Maria Maqsood, Nimrah Ashraf, Farzeen Asghar, Nauman Khalid   +4 more
wiley   +1 more source

Juvenile granulosa cell tumor of the testis: prenatal diagnosis and prescrotal approach

Italian Journal of Pediatrics, 2012
Neonatal testicular tumors are rare and should be considered in the differential diagnosis of newborn scrotal masses. Juvenile granulosa cell tumor (JGCT) accounts for about 5% of all prepubertal testis tumors.
Bulotta Anna Lavinia, Molinaro Francesco, Angotti Rossella, Ferrara Francesco, Di Maggio Giovanni, Bindi Edoardo, Messina Mario   +6 more
doaj   +1 more source

Adult type granulosa cell tumor of the testis with a heterologous sarcomatous component: case report and review of the literature

Diagnostic Pathology, 2014
Adult testicular granulosa cell tumors are rare sex cord- stromal tumors of which only 45 have been previously reported. As compared with their ovarian counterparts, these tumors may follow a more aggressive course because the proportion of malignant ...
T. Schubert, R. Stoehr, A. Hartmann, S. Schöne, M. Löbelenz, G. Mikuz   +5 more
semanticscholar   +1 more source

Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa‐Cell Programs

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
PKC‐mediated phosphorylation of FOXL2 weakens DNA binding, alters subnuclear localization and protein interactions, and reshapes FOXL2‐dependent transcriptional programs in granulosa cells, supporting a reversible mechanism that modulates FOXL2 activity through phosphorylation of its DNA‐binding domain. ABSTRACT FOXL2 is a forkhead transcription factor
Ludovic Mousseron, Despoina Chousianiti, Francis Poulat, Bérangère Legois, Reiner A. Veitia, Anne‐Laure Todeschini   +5 more
wiley   +1 more source

Late retroperitoneal recurrence of adult-type ovarian granulosa cell tumors: Two case reports and literature review

Science Progress
Adult-type ovarian granulosa cell tumors are rare low-grade malignancies characterized by late recurrence and atypical clinical manifestations. This study reports two cases of recurrent adult-type ovarian granulosa cell tumor with distinct timelines and ...
Yutao Wang, Ting Liu, Xi Deng, Shuben Sun   +3 more
doaj   +1 more source

Intraoperative scrape cytology: Adult granulosa cell tumor of ovary

Journal of Cytology, 2011
Adult granulosa cell tumor is often a hormonally active stromal cell neoplasm of the ovary with malignant potential. Intra-operative pathological assessment is a valuable tool in guiding optimal surgical treatment in patients.
Prabal Deb, Ajay Malik, Kavita K Sinha
doaj   +1 more source

FOXL2, GATA4, and SMAD3 Co-Operatively Modulate Gene Expression, Cell Viability and Apoptosis in Ovarian Granulosa Cell Tumor Cells

PLoS ONE, 2014
Aberrant ovarian granulosa cell proliferation and apoptosis may lead to granulosa cell tumors (GCT), the pathogenesis of which involves transcription factors GATA4, FOXL2, and SMAD3. FOXL2 gene harbors a point mutation (C134W) in a vast majority of GCTs.
M. Anttonen, M. Pihlajoki, Noora Andersson, A. Georges, D. L’hôte, Sanna Vattulainen, A. Färkkilä, L. Unkila‐Kallio, R. Veitia, M. Heikinheimo   +9 more
semanticscholar   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, Volume 13, Issue 43, 3 August 2026.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Embryonic Mediators of Embryo–Uterus Communication, Implantation and Pregnancy

Molecular Reproduction and Development, Volume 93, Issue 8, August 2026.
ABSTRACT Successful reproduction in eutherian mammals requires intimate connections between the embryo and uterus, involving adhesion, attachment and placentation, with or without invasion of the endometrium. The complex dialogue between embryo and uterus involves numerous molecules and pathways.
Keith E. Latham
wiley   +1 more source

Dysgerminoma and granulosa cell tumor in a bitch

Brazilian Journal of Veterinary Pathology, 2016
Dysgerminoma and granulosa cell tumor are neoplasms of the ovary of domestic animals, originating from germ cells and sex-cords cells, respectively. These neoplasms generally occur unilaterally, and usually as a single neoplasm.
Ayisa R. Oliveira, Mayra C. Flecher, Flávia F. Jabour, Tayse D. Souza, Isabela Hardt, Fernanda T. Vieira, Alice C. Rassele, Gabriel C. Vicente, Flávia M. Machado   +8 more
doaj   +1 more source