Results 111 to 120 of about 49,325 (246)
Immunohistochemical and mRNA Localization of the Angiotensin II Receptor Subtype 2 (AT2) in Follicular Granulosa Cells of the Rat Ovary [PDF]
Nicholas Obermüller +6 more
openalex +1 more source
ABSTRACT Background The PAPPA2 gene encodes a metalloproteinase critical for regulating insulin‐like growth factor (IGF) bioavailability through cleavage of insulin‐like growth factor‐binding protein 5 (IGFBP5). While its role in human and murine reproduction is documented, its function in sheep reproductive traits remains underexplored. Objective This
Yuanyuan Wang +5 more
wiley +1 more source
Considerations of Fertility in Elite Sportswomen: A Narrative Review
ABSTRACT Background Increasingly more women are participating in professional and recreational sports. Whilst vigorous intensity physical activity is considered beneficial, evidence demonstrates higher rates of menstrual disturbance in elite athletes. There is less clear evidence on the impact of elite‐level exercise on fertility outcomes.
Ariadne L'Heveder +11 more
wiley +1 more source
Tumour necrosis factor-alpha inhibits follicle stimulating hormone-induced granulosa cell oestradiol secretion in the human: dependence on size of follicle [PDF]
Valerie Montgomery Rice +3 more
openalex +1 more source
Spatial Transcriptomic Characteristics of the Aging Human Ovary
Troughing constructing a comprehensive spatiotemporal aging atlas on young and aged human ovaries, we revealed distinct cell types, cellular interactions, and aging‐associated gene expression changes due to aging. Specially, we detected an increase in DLK1:NOTCH3 expression which may contribute to the dysregulation of ovarian functions.
Meiling Zhang +14 more
wiley +1 more source
Differential Regulation of Inhibin B and Inhibin A by Follicle-Stimulating Hormone and Local Growth Factors in Human Granulosa Cells from Small Antral Follicles1 [PDF]
Corrine K. Welt, Alan L. Schneyer
openalex +1 more source
Spatiotemporal Crosstalk Between Oocyte and the Microenvironment Governs Preovulatory Follicle Aging
Preovulatory follicle aging is characterized by two distinct phases—early oocyte protective and late degenerative phases. The degenerative phase involves a positive feedback loop between oocyte mitochondrial dysfunction mediated by a mitochondrial‐localized microprotein PIGBOS, and granulosa cell functional decline through a circular RNA circdlg1 ...
Xin Yi Koh +7 more
wiley +1 more source
We report the development and application of a mouse ovarian somatic organoid model to elucidate a fundamental new understanding of the cell biology of the aging ovarian microenvironment. ABSTRACT Ovarian somatic cells are essential for reproductive function, but no existing ex vivo models recapitulate the cellular heterogeneity or interactions within ...
Shweta S. Dipali +10 more
wiley +1 more source

