Results 251 to 260 of about 78,129 (305)

Antagonistic effects of the cytotoxic molecules granzyme B and TRAIL in the immunopathogenesis of sclerosing cholangitis. [PDF]

Hepatology
Kellerer M, Javed S, Casar C, Will N, Berkhout LK, Schwinge D, Krebs CF, Schramm C, Neumann K, Tiegs G.   +9 more
europepmc   +1 more source

Modeling antibody drug conjugate potential using a granzyme B antibody fusion protein. [PDF]

BMC Biol
Anderson TS, McCormick AL, Smith SL, Lowe DB.   +3 more
europepmc   +1 more source

Granzyme B-activated IL18 potentiates αβ and γδ CAR T cell immunotherapy in a tumor-dependent manner. [PDF]

Mol Ther
Hull CM, Larcombe-Young D, Mazza R, George M, Davies DM, Schurich A, Maher J.   +6 more
europepmc   +1 more source

Retracted: Therapeutical Significance of Serpina3n Subsequent Cerebral Ischemia via Cytotoxic Granzyme B Inactivation. [PDF]

Biomed Res Int
International BR.
europepmc   +1 more source

Granzyme B+ B cells detected by single-cell sequencing are associated with prognosis in patients with intrahepatic cholangiocarcinoma following liver transplantation. [PDF]

Cancer Immunol Immunother
Zhu JQ, Zhu Y, Qi M, Zeng Y, Liu ZJ, Ding C, Zhang T, Li XL, Han DD, He Q.   +9 more
europepmc   +1 more source

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Apoptosis induced by granzyme B

Russian Journal of Bioorganic Chemistry, 2008
Results of biochemical studies of apoptosis reactions induced by granzyme B are considered and summarized. Special attention is paid to the reactions of procaspase activation and limited proteolysis of apoptotic targets. Found values of kinetic constants of granzyme B-mediated enzymatic reactions are listed.
A V, Sintsov, E I, Kovalenko, M A, Khanin   +2 more
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Granzyme B-Induced Cell Death

Acta Haematologica, 2003
Granzyme B (GrB) is a serine protease that is released by cytotoxic lymphocytes to kill virus-infected and tumor cells. Recent advances in the understanding of GrB have stressed the importance of reassessing the mechanisms by which GrB accomplishes its death functions.
Felipe, Andrade, Livia A, Casciola-Rosen, Antony, Rosen   +2 more
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Granzyme B: a natural born killer

Immunological Reviews, 2003
Summary:  A main pathway used by cytotoxic T lymphocytes (CTLs) and natural killer cells to eliminate pathogenic cells is via exocytosis of granule components in the direction of the target cell, delivering a lethal hit of cytolytic molecules. Amongst these, granzyme B and perforin have been shown to induce CTL‐mediated target cell DNA fragmentation ...
Sarah J, Lord, Ray V, Rajotte, Gregory S, Korbutt, R Chris, Bleackley   +3 more
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Granzyme B Receptor

Science Signaling, 2000
One key component of the mechanism by which cytotoxic T lymphocytes (CTLs) attack virus-infected or tumor cells is release of cytolytic molecules like the protease granzyme B (grB). Motyka et al. report the discovery that grB uptake is mediated by a receptor--the cation-independent mannose 6-phosphate receptor (CI ...
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