Results 1 to 10 of about 51,436 (163)

Degranulation enhances presynaptic membrane packing, which protects NK cells from perforin-mediated autolysis.

PLoS Biology, 2021
Natural killer (NK) cells kill a target cell by secreting perforin into the lytic immunological synapse, a specialized interface formed between the NK cell and its target.
Yu Li, Jordan S Orange
doaj   +2 more sources

Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

eLife, 2015
Perforin-2 (MPEG1) is a pore-forming, antibacterial protein with broad-spectrum activity. Perforin-2 is expressed constitutively in phagocytes and inducibly in parenchymal, tissue-forming cells. In vitro, Perforin-2 prevents the intracellular replication
Ryan M McCormack, Lesley R de Armas, Motoaki Shiratsuchi, Desiree G Fiorentino, Melissa L Olsson, Mathias G Lichtenheld, Alejo Morales, Kirill Lyapichev, Louis E Gonzalez, Natasa Strbo, Neelima Sukumar, Olivera Stojadinovic, Gregory V Plano, George P Munson, Marjana Tomic-Canic, Robert S Kirsner, David G Russell, Eckhard R Podack   +17 more
doaj   +2 more sources

Reassessing granzyme B: unveiling perforin-independent versatility in immune responses and therapeutic potentials

Frontiers in Immunology
The pivotal role of Granzyme B (GzmB) in immune responses, initially tied to cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, has extended across diverse cell types and disease models. A number of studies have challenged conventional notions,
Raylynn Thompson, Xuefang Cao, Xuefang Cao   +2 more
doaj   +2 more sources

Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2

eLife, 2015
Perforin-2 (MPEG1) is an effector of the innate immune system that limits the proliferation and spread of medically relevant Gram-negative, -positive, and acid fast bacteria.
Ryan M McCormack, Kirill Lyapichev, Melissa L Olsson, Eckhard R Podack, George P Munson   +4 more
doaj   +2 more sources

Regulation of expression and trafficking of perforin-2 by LPS and TNF-α

Cellular Immunology, 2017
Motoaki Shiratsuchi, Yoshihiro Ogawa, Yasuhiro Nakashima   +2 more
exaly   +2 more sources

Inhibition of Perforin-Mediated Neurotoxicity Attenuates Neurological Deficits After Ischemic Stroke

Frontiers in Cellular Neuroscience, 2021
Perforin-mediated cytotoxicity plays a crucial role in microbial defense, tumor surveillance, and primary autoimmune disorders. However, the contribution of the cytolytic protein perforin to ischemia-induced secondary tissue damage in the brain has not ...
Yuhualei Pan, Yuhualei Pan, Dan Tian, Dan Tian, Huan Wang, Huan Wang, Yushang Zhao, Yushang Zhao, Chengjie Zhang, Song Wang, Song Wang, Dan Xie, Dong Zhang, Dong Zhang, Yanbing Zhu, Yanbing Zhu, Yongbo Zhang   +16 more
doaj   +1 more source

Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells

bioRxiv, 2023
During initiation of antiviral and antitumour T cell-mediated immune responses, dendritic cells (DCs) cross-present exogenous antigens on MHC class I.
Pablo Rodríguez-Silvestre, Marco Laub, A. Davies, J. Schessner, Patrycja A. Krawczyk, Benjamin J. Tuck, W. McEwan, Georg H. H. Borner, Patrycja Kozik   +8 more
semanticscholar   +1 more source

Caspase-7 activates ASM to repair gasdermin and perforin pores

Nature, 2022
Among the caspases that cause regulated cell death, a unique function for caspase-7 has remained elusive. Caspase-3 performs apoptosis, whereas caspase-7 is typically considered an inefficient back-up.
K. Nozaki, Vivien I Maltez, Manira Rayamajhi, Alan L. Tubbs, Joseph E. Mitchell, Carolyn A. Lacey, Carissa K. Harvest, Lupeng Li, W. Nash, H. N. Larson, Benjamin D. McGlaughon, Nathaniel J. Moorman, Michael G. Brown, J. Whitmire, Edward A. Miao   +14 more
semanticscholar   +1 more source

Surface plasmon resonance and microscale thermophoresis approaches for determining the affinity of perforin for calcium ions

Frontiers in Immunology, 2023
Perforin is a pore-forming protein that plays a crucial role in the immune system by clearing virus-infected or tumor cells. It is released from cytotoxic granules of immune cells and forms pores in targeted lipid membranes to deliver apoptosis-inducing ...
Omar Naneh, Mirijam Kozorog, Franci Merzel, Robert Gilbert, Gregor Anderluh   +4 more
doaj   +1 more source

Intracellular Staphylococcus aureus triggers pyroptosis and contributes to inhibition of healing due to Perforin-2 suppression.

Journal of Clinical Investigation, 2021
Impaired wound healing associated with recurrent Staphylococcus aureus infection and unresolved inflammation are hallmarks of non-healing diabetic foot ulcers (DFU). Perforin-2, an innate immunity molecule against intracellular bacteria, limits cutaneous
I. Pastar, A. Sawaya, J. Marjanović, J. Burgess, N. Strbo, K. Rivas, T. Wikramanayake, Cheyanne R. Head, Rivka C. Stone, I. Jozic, Olivera Stojadinović, Eran Y. Kornfeld, R. Kirsner, H. Lev-Tov, M. Tomic‐Canic   +14 more
semanticscholar   +1 more source