Results 1 to 10 of about 53,251 (162)
Frontiers in Immunology, 2021 Granzyme B is a renowned effector molecule primarily utilized by CTLs and NK cells against ill-defined and/or transformed cells during immunosurveillance.
Jishuang Liu, Ye Qiu, Qiu Zhidong
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Changes in Cell-Mediated Immunity (IFN-γ and Granzyme B) Following Influenza Vaccination
Viruses, 2021 Interferon gamma (IFN-γ) is considered a key moderator of cell-mediated immunity. However, little is known about its association with granzyme B, which plays an important role in the effector function of cytotoxic T lymphocytes (CTLs).
Naruhito Otani +2 more
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Granzyme B PET Imaging of the Innate Immune Response
Molecules, 2020 The human immune system is a complex system which protects against invaders and maintains tissue homeostasis. It is broadly divided into the innate and adaptive branches. Granzyme B is serine protease that plays an important role in both and can serve as
Mikhail Doubrovin +2 more
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Role of Serine Proteases at the Tumor-Stroma Interface
Frontiers in Immunology, 2022 During tumor development, invasion and metastasis, the intimate interaction between tumor and stroma shapes the tumor microenvironment and dictates the fate of tumor cells.
Ravichandra Tagirasa, Euna Yoo
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ALFA-PRF: a novel approach to detect murine perforin release from CTLs into the immune synapse
Frontiers in Immunology, 2022 When killing through the granule exocytosis pathway, cytotoxic lymphocytes release key effector molecules into the immune synapse, perforin and granzymes, to initiate target cell killing.
Jesse A. Rudd-Schmidt +8 more
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Journal of Cell Science, 2006 Defence against virally infected and malignant cells depends on the action of cytotoxic T lymphocytes and natural killer cells ([Barry and Bleackley, 2002][1]; [Russell and Ley, 2002][2]). Although these use several mechanisms to eliminate target cells, the principal event is secretion of ...
Bots, Michael, Medema, Jan Paul
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Frontiers in Immunology, 2023 Granzymes A and K are two highly homologous serine proteases expressed by mammalian cytotoxic T cells (CTL) and natural killer cells (NK). Granzyme A is the most abundant of the different granzymes (gzms) expressed by these two cell types.
Erdem Aybay +9 more
doaj +1 more source
Frontiers in Immunology, 2021 Natural Killer (NK) cells are cytotoxic lymphocytes critical to the innate immune system. We found that germline deficiency of NF-κB c-Rel results in a marked decrease in cytotoxic function of NK cells, both in vitro and in vivo, with no significant ...
Yorleny Vicioso +8 more
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The Expanding Arsenal of Cytotoxic T Cells
Frontiers in Immunology, 2022 Cytotoxic T cells (CTLs) are the main cellular mediators of the adaptive immune defenses against intracellular pathogens and malignant cells. Upon recognition of specific antigen on their cellular target, CTLs assemble an immunological synapse where they
Chiara Cassioli, Cosima T. Baldari
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Temporal Dynamics of Serum Perforin and Granzyme during the Acute Phase of SARS-CoV-2 Infection
Vaccines, 2023 Background: As many SARS-CoV-2 infections are asymptomatic, it could be useful to be able to determine how much time has passed since infection. We explored the changes in the temporal levels of T cell-related proteins (including perforin and granzymes ...
MD Tazikur Rahman +5 more
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