Results 21 to 30 of about 53,350 (260)

Control of granzymes by serpins [PDF]

Cell Death & Differentiation, 2009
Although proteolysis mediated by granzymes has an important role in the immune response to infection or tumours, unrestrained granzyme activity may damage normal cells. In this review, we discuss the role of serpins within the immune system, as specific regulators of granzymes. The well-characterised human granzyme B-SERPINB9 interaction highlights the
D, Kaiserman, P I, Bird
openaire   +2 more sources

Granzymes—Their Role in Colorectal Cancer

International Journal of Molecular Sciences, 2022
Colorectal cancer (CRC) is among the most common malignancies worldwide. CRC is considered a heterogeneous disease due to various clinical symptoms, biological behaviours, and a variety of mutations. A number of studies demonstrate that as many as 50% of CRC patients have distant metastases at the time of diagnosis.
Sara Pączek, Marta Łukaszewicz-Zając, Barbara Mroczko   +2 more
openaire   +2 more sources

Perforin and granzyme B have separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout mice. [PDF]

PLoS ONE, 2013
The granzyme B/perforincytotoxic pathway is a well established mechanism of initiating target cell apoptosis. Previous studies have suggested a role for the granzyme B/perforin cytotoxic pathway in vulnerable atherosclerotic plaque formation.
Paul R Hiebert, Wendy A Boivin, Hongyan Zhao, Bruce M McManus, David J Granville   +4 more
doaj   +1 more source

Gasdermins: a dual role in pyroptosis and tumor immunity

Frontiers in Immunology
The gasdermin (GSDM) protein family plays a pivotal role in pyroptosis, a process critical to the body’s immune response, particularly in combatting bacterial infections, impeding tumor invasion, and contributing to the pathogenesis of various ...
Jiayi Yang, Jiayi Yang, Jiayi Yang, Jingting Jiang, Jingting Jiang, Jingting Jiang   +5 more
doaj   +1 more source

NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection

Cell Reports, 2023
Summary: Genital herpes is characterized by recurrent episodes of epithelial blistering. The mechanisms causing this pathology are ill defined. Using a mouse model of vaginal herpes simplex virus 2 (HSV-2) infection, we show that interleukin-18 (IL-18 ...
Ying Shiang Lim, Aisha G. Lee, Xiaoping Jiang, Jason M. Scott, Adjoa Cofie, Sandeep Kumar, Dania Kennedy, David J. Granville, Haina Shin   +8 more
doaj   +1 more source

Granzyme A, a Stealth Killer in the Mitochondrion [PDF]

Cell, 2008
The induction of caspase-independent cell death by killer lymphocytes involves the serine protease granzyme A (GzmA). In this issue, Martinvalet et al. (2008) show that GzmA penetrates the mitochondrial matrix without perturbing normal mitochondrial functions. In the mitochondrial matrix, GzmA cleaves NDUFS3 (a component of the electron transport chain)
Lucken-Ardjomande, Safa, Martinou, Jean-Claude   +1 more
openaire   +4 more sources

Vaginal Chlamydial Clearance Following Primary or Secondary Infection in Mice Occurs Independently of TNF-α

Frontiers in Cellular and Infection Microbiology, 2013
The role of TNF-α in chlamydial clearance is uncertain. Antibody-mediated depletion of TNF-α in mice and guinea pigs has been shown not to significantly affect chlamydial clearance, whereas production of TNF-α in addition to IFN-γ from T cells has been ...
Sangamithra eKamalakaran, Bharat eChaganty, Rishein eGupta, Rishein eGupta, M. Neal Guentzel, M. Neal Guentzel, James Patrick Chambers, James Patrick Chambers, Ashlesh eMurthy, Bernard eArulanandam, Bernard eArulanandam   +10 more
doaj   +1 more source

Comparative immune responses to Mycobacterium tuberculosis in people with latent infection or sterilizing protection

iScience, 2023
Summary: There is great need for vaccines against tuberculosis (TB) more efficacious than the licensed BCG. Our goal was to identify new vaccine benchmarks by identifying immune responses that distinguish individuals able to eradicate the infection (TB ...
Emilie Jalbert, Cuining Liu, Vidya Mave, Nancy Lang, Anju Kagal, Chhaya Valvi, Mandar Paradkar, Nikhil Gupte, Rahul Lokhande, Renu Bharadwaj, Vandana Kulkarni, Amita Gupta, Adriana Weinberg   +12 more
doaj   +1 more source

Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes

Frontiers in Immunology, 2022
Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4+ Th17 cells are considered pathogenic in MS and are harmful to OLs.
Hélène Jamann, Hélène Jamann, Qiao-Ling Cui, Haritha L. Desu, Haritha L. Desu, Florian Pernin, Olivier Tastet, Alexandre Halaweh, Alexandre Halaweh, Negar Farzam-kia, Negar Farzam-kia, Victoria Hannah Mamane, Victoria Hannah Mamane, Oumarou Ouédraogo, Oumarou Ouédraogo, Aurélie Cleret-Buhot, Audrey Daigneault, Renaud Balthazard, Renaud Balthazard, Wendy Klement, Wendy Klement, Florent Lemaître, Florent Lemaître, Nathalie Arbour, Nathalie Arbour, Jack Antel, Jo Anne Stratton, Catherine Larochelle, Catherine Larochelle   +28 more
doaj   +1 more source

Modulation of Inflammation by Extracellular Granzyme A [PDF]

Frontiers in Immunology, 2020
Granzyme A (GrA) has long been recognized as one of the key players in the induction of cell death of neoplastic, foreign or infected cells after granule delivery by cytotoxic cells. While the cytotoxic potential of GrA is controversial in current literature, accumulating evidence now indicates roles for extracellular GrA in modulating inflammation and
Kim R. van Daalen, Josephine F. Reijneveld, Niels Bovenschen, Niels Bovenschen   +3 more
openaire   +4 more sources