Results 11 to 20 of about 53,350 (260)
Endometrial Cancer Suppresses CD8+ T Cell-Mediated Cytotoxicity in Postmenopausal Women
Frontiers in Immunology, 2021 Endometrial cancer is the most common gynecological cancer. To investigate how it suppresses host immune function, we isolated CD8+ T cells from endometrial endometroid carcinomas and adjacent non-cancerous endometrium and determined if the tumor ...
Mickey V. Patel +5 more
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Acta Veterinaria, 2023 Some cats live at home with their owners while others live unattended on the streets or in shelters. One might expect that the owned cats would be better prepared for diseases with vaccinations, and good care and feeding conditions whereas the stray cats
Temizkan Mehmet Cevat +4 more
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Perforinopathy: a spectrum of human immune disease caused by defective perforin delivery or function
Frontiers in Immunology, 2013 Congenital perforin deficiency is considered a rare cause of human immunopathology and immune dysregulation, and classically presents as a fatal illness early in infancy.
Joseph A. Trapani, Ilia eVoskoboinik
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Widespread and dynamic expression of granzyme C by skin-resident antiviral T cells
Frontiers in Immunology, 2023 After recognition of cognate antigen (Ag), effector CD8+ T cells secrete serine proteases called granzymes in conjunction with perforin, allowing granzymes to enter and kill target cells.
Ramon A. Lujan +6 more
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Interleukin-4 Supports the Suppressive Immune Responses Elicited by Regulatory T Cells
Frontiers in Immunology, 2017 Interleukin-4 (IL-4) has been considered as one of the tolerogenic cytokines in many autoimmune animal models and clinical settings. Despite its role in antagonizing pathogenic Th1 responses, little is known about whether IL-4 possesses functions that ...
Wei-Cheng Yang +13 more
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Feedback Regulation of Cathepsin C by the Propeptide Dipeptides of Granzymes A and B
Acta Chimica Slovenica, 2019 Granzymes A and B are activated by proteolytic removal of their N-terminal dipeptides by cathepsin C (dipeptidyl-peptidase I). However, the possible physiological role of the cleaved dipeptides Glu-Lys and Gly-Glu is not yet understood.
Janja Božič, Iztok Dolenc
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Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice. [PDF]
PLoS ONE, 2012 Pancreatic beta cell destruction in type 1 diabetes is mediated by cytotoxic CD8(+) T lymphoctyes (CTL). Granzyme B is an effector molecule used by CTL to kill target cells.
Zia U Mollah +7 more
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Granzymes in cancer and immunity [PDF]
Cell Death & Differentiation, 2010 Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells are indispensable factors in the body's ongoing defence against viral infection and tumor development. CTL/NK cells recognize and kill infected or aberrant target cells by two major pathways: either through introduction of a battery of proteases - called granzymes - to the target cell cytosol,
S P, Cullen, M, Brunet, S J, Martin
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Medicina, 2023 Background and Objectives: Inflammatory interstitial fibrosis and tubular atrophy (i-IFTA) is an inflammation in the area of tubular atrophy and fibrosis.
Brijesh Yadav +4 more
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A quarter century of granzymes [PDF]
Cell Death & Differentiation, 2011 Granzymes (Grs) were discovered just over a quarter century ago. They are produced by cytotoxic T cells and natural killer cells and are released upon interaction with target cells. Intensive biochemical, genetic, and biological studies have been performed in order to study their roles in immunity and inflammation.
C L, Ewen, K P, Kane, R C, Bleackley
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