Modulation of Inflammation by Extracellular Granzyme A [PDF]
Frontiers in Immunology, 2020 Granzyme A (GrA) has long been recognized as one of the key players in the induction of cell death of neoplastic, foreign or infected cells after granule delivery by cytotoxic cells.
Kim R. van Daalen +3 more
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Editorial: Roles of granzymes in inflammation, aging, and autoimmunity [PDF]
Frontiers in ImmunologyFehim Esen, Christopher T. Turner
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Gzmk+ CD8 T cells in inflammatory diseases [PDF]
Frontiers in ImmunologyT cells are integral to the immune response, with distinct subsets exhibiting specialized functions, a phenomenon well-characterized in helper CD4+ T cells. Recent advancements in single-cell RNA sequencing (scRNA-seq) have facilitated the identification
Cui Xin +3 more
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Oxidative and Non-Oxidative Antimicrobial Activities of the Granzymes
Frontiers in Immunology, 2021 Cell-mediated cytotoxicity is an essential immune defense mechanism to fight against viral, bacterial or parasitic infections. Upon recognition of an infected target cell, killer lymphocytes form an immunological synapse to release the content of their ...
Marilyne Lavergne +5 more
doaj +1 more source
Widespread and dynamic expression of granzyme C by skin-resident antiviral T cells
Frontiers in Immunology, 2023 After recognition of cognate antigen (Ag), effector CD8+ T cells secrete serine proteases called granzymes in conjunction with perforin, allowing granzymes to enter and kill target cells.
Ramon A. Lujan +6 more
doaj +1 more source
Frontiers in Immunology, 2022 NK cells are key mediators of immune cell-mediated cytotoxicity toward infected and transformed cells, being one of the main executors of cell death in the immune system.
Ariel Ramírez-Labrada +24 more
doaj +1 more source
Role of the granzyme family in rheumatoid arthritis: Current Insights and future perspectives
Frontiers in Immunology, 2023 Rheumatoid arthritis (RA) is a complex autoimmune disease characterized by chronic inflammation that affects synovial tissues of multiple joints.
Yixin Zheng +16 more
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Temporal Dynamics of Serum Perforin and Granzyme during the Acute Phase of SARS-CoV-2 Infection
Vaccines, 2023 Background: As many SARS-CoV-2 infections are asymptomatic, it could be useful to be able to determine how much time has passed since infection. We explored the changes in the temporal levels of T cell-related proteins (including perforin and granzymes ...
MD Tazikur Rahman +5 more
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Hsp70, in Combination with IL-15 and PD-1 Blocker, Interferes with The Induction of Cytotoxic NK Cells in Relapsed Acute Myeloid Leukemia Patients [PDF]
Cell Journal, 2023 Objective: Natural killer (NK) cells are critical immune cells for acute myeloid leukemia (AML) targeting. However,little is known about the relationship between using checkpoint inhibitors and heat shock protein 70 (Hsp70) as NK cellactivators to ...
Javad Firouzi +8 more
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The Multifaceted Function of Granzymes in Sepsis: Some Facts and a Lot to Discover
Frontiers in Immunology, 2020 Sepsis is a serious global health problem. In addition to a high incidence, this syndrome has a high mortality and is responsible for huge health expenditure. The pathophysiology of sepsis is very complex and it is not well-understood yet. However, it is
Marcela Garzón-Tituaña +18 more
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