Results 21 to 30 of about 13,036 (257)

Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner.

PLoS Pathogens, 2020
Human cytomegalovirus (HCMV) is the most frequent viral cause of congenital defects and can trigger devastating disease in immune-suppressed patients. Cytotoxic lymphocytes (CD8+ T cells and NK cells) control HCMV infection by releasing interferon-γ and ...
Liling Shan, Shuang Li, Jan Meeldijk, Bernadet Blijenberg, Astrid Hendriks, Karlijn J W M van Boxtel, Sara P H van den Berg, Ian J Groves, Martin Potts, Adriana Svrlanska, Thomas Stamminger, Mark R Wills, Niels Bovenschen   +12 more
doaj   +1 more source

Granzymes, IL-16, and poly(ADP-ribose) polymerase 1 increase during wildfire smoke exposure

Journal of Allergy and Clinical Immunology: Global, 2023
Background: Given the increasing prevalence of wildfires worldwide, understanding the effects of wildfire air pollutants on human health—particularly in specific immunologic pathways—is crucial.
Juan Aguilera, MD, PhD, Abhinav Kaushik, PhD, Nicholas Cauwenberghs, PhD, Anja Heider, PhD, Ismail Ogulur, PhD, Duygu Yazici, PhD, Eric Smith, BS, Shifaa Alkotob, MD, Mary Prunicki, MD, PhD, Cezmi A. Akdis, MD, PhD, Kari C. Nadeau, MD, PhD   +10 more
doaj   +1 more source

Control of granzymes by serpins [PDF]

Cell Death & Differentiation, 2009
Although proteolysis mediated by granzymes has an important role in the immune response to infection or tumours, unrestrained granzyme activity may damage normal cells. In this review, we discuss the role of serpins within the immune system, as specific regulators of granzymes. The well-characterised human granzyme B-SERPINB9 interaction highlights the
D, Kaiserman, P I, Bird
openaire   +2 more sources

Natural killer cells kill extracellular Pseudomonas aeruginosa using contact-dependent release of granzymes B and H.

PLoS Pathogens, 2022
Pseudomonas aeruginosa is an opportunistic pathogen that often infects individuals with the genetic disease cystic fibrosis, and contributes to airway blockage and loss of lung function.
David D Feehan, Khusraw Jamil, Maria J Polyak, Henry Ogbomo, Mark Hasell, Shu Shun Li, Richard F Xiang, Michael Parkins, Joseph A Trapani, Joe J Harrison, Christopher H Mody   +10 more
doaj   +1 more source

Granzyme A, a Stealth Killer in the Mitochondrion [PDF]

Cell, 2008
The induction of caspase-independent cell death by killer lymphocytes involves the serine protease granzyme A (GzmA). In this issue, Martinvalet et al. (2008) show that GzmA penetrates the mitochondrial matrix without perturbing normal mitochondrial functions. In the mitochondrial matrix, GzmA cleaves NDUFS3 (a component of the electron transport chain)
Lucken-Ardjomande, Safa, Martinou, Jean-Claude   +1 more
openaire   +4 more sources

Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity

Frontiers in Immunology, 2023
Granzymes A and K are two highly homologous serine proteases expressed by mammalian cytotoxic T cells (CTL) and natural killer cells (NK). Granzyme A is the most abundant of the different granzymes (gzms) expressed by these two cell types.
Erdem Aybay, Jinhye Ryu, Zhirong Fu, Srinivas Akula, Srinivas Akula, Erika Mendez Enriquez, Jenny Hallgren, Sara Wernersson, Anna-Karin Olsson, Lars Hellman   +9 more
doaj   +1 more source

Human NK cell lytic granules and regulation of their exocytosis.

Frontiers in Immunology, 2012
Natural killer (NK) cells form a subset of lymphocytes that play a key role in immuno-surveillance and host defense against cancer and viral infections. They recognize stressed cells through a variety of germline-encoded activating cell surface receptors
Konrad eKrzewski, John Ernest Coligan
doaj   +1 more source

Lytic granule exocytosis at immune synapses: lessons from neuronal synapses

Frontiers in Immunology, 2023
Regulated exocytosis is a central mechanism of cellular communication. It is not only the basis for neurotransmission and hormone release, but also plays an important role in the immune system for the release of cytokines and cytotoxic molecules.
Hsin-Fang Chang, Claudia Schirra, Varsha Pattu, Elmar Krause, Ute Becherer   +4 more
doaj   +1 more source

Expression of intra- and extracellular granzymes in patients with typhoid fever.

PLoS Neglected Tropical Diseases, 2017
BackgroundTyphoid fever, caused by the intracellular pathogen Salmonella (S.) enterica serovar Typhi, remains a major cause of morbidity and mortality worldwide.
Hanna K de Jong, Maria Isabel Garcia-Laorden, Arie J Hoogendijk, Christopher M Parry, Rapeephan R Maude, Arjen M Dondorp, Mohammed Abul Faiz, Tom van der Poll, Willem Joost Wiersinga   +8 more
doaj   +1 more source

Ectopically expressed perforin-1 is proapoptotic in tumor cell lines by increasing caspase-3 activity and the nuclear translocation of cytochrome C. [PDF]

PLoS ONE, 2012
Perforin-1 (PRF), a cytotoxic lymphocyte pore-forming protein, plays an important role in the action of cytotoxic T cells and natural killer cells in that it causes the lysis of abnormal body cells and the elimination of virus-infected cells and tumors ...
Li-Feng Wang, Fang Wang, Jun-Tang Li, Wei-Hong Wen, Jing Zhao, Lin-Tao Jia, Yan-Ling Meng, Yun-Xin Cao, Li-Bo Yao, Si-Yi Chen, Yan-Ming Xu, An-Gang Yang   +11 more
doaj   +1 more source