Results 31 to 40 of about 13,036 (257)

Granzyme K mediates IL-23-dependent inflammation and keratinocyte proliferation in psoriasis

Frontiers in Immunology
Psoriasis is an inflammatory disease with systemic manifestations that most commonly presents as itchy, erythematous, scaly plaques on extensor surfaces.
Katlyn C. Richardson, Katlyn C. Richardson, Katlyn C. Richardson, Alexandre Aubert, Alexandre Aubert, Alexandre Aubert, Christopher T. Turner, Christopher T. Turner, Christopher T. Turner, Layla Nabai, Layla Nabai, Layla Nabai, Sho Hiroyasu, Sho Hiroyasu, Sho Hiroyasu, Megan A. Pawluk, Megan A. Pawluk, Megan A. Pawluk, Rachel A. Cederberg, Rachel A. Cederberg, Hongyan Zhao, Hongyan Zhao, Hongyan Zhao, Karen Jung, Karen Jung, Karen Jung, Angela Burleigh, Richard I. Crawford, Richard I. Crawford, David J. Granville, David J. Granville, David J. Granville   +31 more
doaj   +1 more source

Interferon-α1b promotes the cytotoxicity of human γδT cells against Daudi cell line [PDF]

Jichu yixue yu linchuang, 2020
Objective To investigate the effect of IFN-α1b on cytotoxic activity of human γδT cells against Daudi cells. Methods Daudi cells treated with IFN-α1b were functioned as target cells and γδT cells treated with IFN-α1b as effector cells.
DANG Guang-lei, ZHANG Xiang-jin, ZHANG Jian-min, CHEN Hui, HE Wei
doaj  

Study of serum Granzyme B in heavy cigarette smokers with and without chronic obstructive pulmonary disease

Egyptian Journal of Chest Disease and Tuberculosis, 2014
Background: Inflammation of the airways is present in COPD with increased number of inflammatory cells including killer cells that lyse their target cells by two mechanisms; membranolysis in which secreted molecules such as granzymes form pores in the ...
Ahmed A. Yousef, Mahmoud M. Alsalahy, Mohammad A. Almahdy, Tarek S. Essawy, Khalid M. Belal   +4 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Administering Blinatumomab via Continuous Intravenous Infusion in Pediatric Patients—A Single‐Institution Retrospective Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab, a CD19xCD3 bispecific T‐cell engager, has become standard therapy for children with de novo B‐cell acute lymphoblastic leukemia (B‐ALL). This retrospective review describes the experience of blinatumomab administration in pediatric patients.
Julia M. Hurley, Ryleigh Krueger, Kellie Joyce, James Stanley, Mary Waskerwitz‐Freyer, Marielle Klunder, David J. Hoogstra   +6 more
wiley   +1 more source

Granzymes in health and diseases: the good, the bad and the ugly

Frontiers in Immunology
Granzymes are a family of serine proteases, composed of five human members: GA, B, H, M and K. They were first discovered in the 1980s within cytotoxic granules released during NK cell- and T cell-mediated killing.
Lavinia Cigalotto, Lavinia Cigalotto, Denis Martinvalet, Denis Martinvalet   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8+ T Cells During an Acute Retroviral Infection

Frontiers in Immunology, 2019
Cytotoxic CD8+ T lymphocytes (CTL) efficiently control acute virus infections but can become exhausted when a chronic infection develops. The checkpoint receptor PD-1 suppresses the functionality of virus-specific CD8+ T cells during chronic infection ...
Paul David, Dominik A. Megger, Tamara Kaiser, Tanja Werner, Jia Liu, Jia Liu, Lieping Chen, Barbara Sitek, Ulf Dittmer, Gennadiy Zelinskyy   +9 more
doaj   +1 more source

Role of Serine Proteases at the Tumor-Stroma Interface

Frontiers in Immunology, 2022
During tumor development, invasion and metastasis, the intimate interaction between tumor and stroma shapes the tumor microenvironment and dictates the fate of tumor cells.
Ravichandra Tagirasa, Euna Yoo
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source