Results 11 to 20 of about 13,036 (257)
Journal of Cell Science, 2006 Defence against virally infected and malignant cells depends on the action of cytotoxic T lymphocytes and natural killer cells ([Barry and Bleackley, 2002][1]; [Russell and Ley, 2002][2]). Although these use several mechanisms to eliminate target cells, the principal event is secretion of ...
Bots, Michael, Medema, Jan Paul
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Human Granzyme B Based Targeted Cytolytic Fusion Proteins
Biomedicines, 2018 Cancer immunotherapy aims to selectively target and kill tumor cells whilst limiting the damage to healthy tissues. Controlled delivery of plant, bacterial and human toxins or enzymes has been shown to promote the induction of apoptosis in cancerous ...
Precious Hlongwane +5 more
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Noncytotoxic functions of killer cell granzymes in viral infections.
PLoS Pathogens, 2021 Cytotoxic lymphocytes produce granules armed with a set of 5 serine proteases (granzymes (Gzms)), which, together with the pore-forming protein (perforin), serve as a major defense against viral infections in humans.
Lisanne C de Jong +3 more
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Frontiers in Oncology, 2021 Angiogenesis is crucial for normal development and homeostasis, but also plays a role in many diseases including cardiovascular diseases, autoimmune diseases, and cancer.
Shuang Li +12 more
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Improved Purification of Human Granzyme A/B and Granulysin Using a Mammalian Expression System
Frontiers in Immunology, 2022 Cytotoxic lymphocytes release proteins contained within the cytoplasmic cytolytic granules after recognition of infected or tumor target cells. These cytotoxic granular proteins (namely granzymes, granulysin, and perforin) are key immunological mediators
Valerio Rasi +10 more
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Increased cystatin F levels correlate with decreased cytotoxicity of cytotoxic T cells
Radiology and Oncology, 2019 Cystatin F is a protein inhibitor of cysteine peptidases, expressed predominantly in immune cells and localised in endosomal/lysosomal compartments. In cytotoxic immune cells cystatin F inhibits both the major pro-granzyme convertases, cathepsins C and H
Prunk Mateja +4 more
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Lipid order and charge protect killer T cells from accidental death
Nature Communications, 2019 Cytotoxic T lymphocytes (CTLs) eliminate virus-infected and cancerous cells by secreting the pore-forming protein (perforin) and pro-apoptotic serine proteases (granzymes).
Jesse A. Rudd-Schmidt +9 more
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Intracellular serine protease inhibitor SERPINB4 inhibits granzyme M-induced cell death. [PDF]
PLoS ONE, 2011 Granzyme-mediated cell death is the major pathway for cytotoxic lymphocytes to kill virus-infected and tumor cells. In humans, five different granzymes (i.e. GrA, GrB, GrH, GrK, and GrM) are known that all induce cell death.
Pieter J A de Koning +9 more
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Cytotoxic Lymphocytes Target HIV-1 Gag Through Granzyme M-Mediated Cleavage
Frontiers in Immunology, 2021 Untreated HIV-1 infection leads to a slow decrease in CD4+ T cell lymphocytes over time resulting in increased susceptibility to opportunistic infections (acquired immunodeficiency syndrome, AIDS) and ultimately death of the infected individual ...
Elisa Saccon +9 more
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Fish Granzyme A Shows a Greater Role Than Granzyme B in Fish Innate Cell-Mediated Cytotoxicity
Frontiers in Immunology, 2019 Granzymes (Gzm) are serine proteases, contained into the secretory granules of cytotoxic cells, responsible for the cell-mediated cytotoxicity (CMC) against tumor cells and intracellular pathogens such as virus and bacteria.
Elena Chaves-Pozo +8 more
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