Results 21 to 30 of about 51,558 (279)

Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity

Science Advances, 2020
Bactericidal perforin-2 assembles an inactivated pre-pore complex and undergoes a 180° reconfiguration for membrane attack. Perforin-2 (MPEG1) is thought to enable the killing of invading microbes engulfed by macrophages and other phagocytes, forming ...
T. Ni, Fang Jiao, Xiulian Yu, Saša Aden, L. Ginger, Sophie I. Williams, Fangfang Bai, V. Pražák, D. Karia, P. Stansfeld, Peijun Zhang, George Munson, G. Anderluh, S. Scheuring, Robert C. G. Gilbert   +14 more
semanticscholar   +1 more source

Recent Advances in Molecular Mechanisms of the NKG2D Pathway in Hepatocellular Carcinoma

Biomolecules, 2020
Hepatocellular carcinoma is a common malignant tumor with high mortality. Its malignant proliferation, invasion, and metastasis are closely related to the cellular immune function of the patients.
Jian Wang, Cun-Di Li, Lin Sun
doaj   +1 more source

Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients.

Journal of Clinical Investigation, 2020
Late-onset inflammatory toxicities resembling hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS) occur after chimeric antigen receptor T cell (CAR T cell) infusion and represent a therapeutic challenge. Given the established
Kazusa Ishii, M. Pouzolles, Christopher D. Chien, R. Erwin-Cohen, M. Kohler, Haiying Qin, Haiyan Lei, Skyler Kuhn, A. Ombrello, Alina Dulau-Florea, M. Eckhaus, Haneen Shalabi, B. Yates, D. Lichtenstein, V. Zimmermann, T. Kondo, J. Shern, H. Young, N. Taylor, N. Shah, T. Fry   +20 more
semanticscholar   +1 more source

Adenosine leakage from perforin-burst extracellular vesicles inhibits perforin secretion by cytotoxic T-lymphocytes

PLoS ONE, 2020
Extracellular vesicles (EVs) in the tumor microenvironment facilitate intercellular communication. Cancer cell-derived EVs act as an immunosuppressor by transporting cargos and presenting transmembrane proteins. By contrast, CD8+ cytotoxic T-lymphocytes (
H. Tadokoro, A. Hirayama, Ryuhei Kudo, Masako Hasebe, Y. Yoshioka, Juntaro Matsuzaki, Yusuke Yamamoto, M. Sugimoto, T. Soga, T. Ochiya   +9 more
semanticscholar   +1 more source

The Role of Perforin [PDF]

Croatian Nursing Journal, 2021
Some literature reviews have been carried out about the role of perforin in medicine. The first step involved a systematic search to identify relevant studies published between 2001 and 2019 in the following electronic databases - EBSCO host, Scopus, Science Direct, Web of Science, and Elsevier.
openaire   +1 more source

Gene therapy of prostate cancer using liposomes containing perforin expression vector driven by the promoter of prostate-specific antigen gene

Scientific Reports, 2022
Perforin secreted from cytotoxic lymphocytes plays a critical role in cancer immunosurveillance. The aim of this study was to investigate the therapeutic potential of liposomes containing perforin expression vector driven by the promotor of prostate ...
Kosuke Mizutani, Kyojiro Kawakami, Yasunori Fujita, Taku Kato, Manabu Takai, Daiki Kato, Koji Iinuma, Takuya Koie, Masafumi Ito   +8 more
doaj   +1 more source

Purification of perforin and study expression of perforin in leukemia patient [PDF]

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology, 2013
This work aimed to study compare of extraction, purification and study gene expression of perforin from ALL, CLL and healthy, to chive this goal, blood samples were collected from 10 Leukemia cases (5 ALL and 5 CLL) and 5 healthy. Comparison of the molecular weight of purified perforin from these groups shows no detectable differences as compared with ...
Najwa Ahmed, Amal Fayyad, Salimeh Mohammadi, Subhi Hamza, Abdul Al-Faisal   +4 more
openaire   +1 more source

Approaching hemophagocytic lymphohistiocytosis

Frontiers in Immunology, 2023
Hemophagocytic Lymphohistiocytosis (HLH) is a rare clinical condition characterized by sustained but ineffective immune system activation, leading to severe and systemic hyperinflammation.
Aurora Chinnici, Aurora Chinnici, Linda Beneforti, Linda Beneforti, Francesco Pegoraro, Francesco Pegoraro, Irene Trambusti, Annalisa Tondo, Claudio Favre, Maria Luisa Coniglio, Elena Sieni   +10 more
doaj   +1 more source

Disruption of IL-33 Signaling Limits Early CD8+ T Cell Effector Function Leading to Exhaustion in Murine Hemophagocytic Lymphohistiocytosis

Frontiers in Immunology, 2018
Danger signals mediated through ST2, the interleukin-33 (IL-33) receptor, amplify CD8+ T cell-mediated inflammation in the murine model of familial hemophagocytic lymphohistiocytosis type 2 (FHL2), and blockade of ST2 provides a potential therapeutic ...
Julia E. Rood, Julia E. Rood, Thomas N. Burn, Thomas N. Burn, Vanessa Neal, Niansheng Chu, Edward M. Behrens, Edward M. Behrens   +7 more
doaj   +1 more source

Tim-3 suppresses the killing effect of Vγ9Vδ2 T cells on colon cancer cells by reducing perforin and granzyme B expression.

Experimental Cell Research, 2019
Gamma delta (γδ) T cell-based tumor immunotherapy has been one of the most promising cancer immunotherapeutic strategies. However, the key regulators of the Vγ9Vδ2 T cell-mediated antitumor response remain unclear.
Xiaomi Li, Huimin Lu, Yan-zheng Gu, Xueguang Zhang, Guangbo Zhang, Tongguo Shi, Weichang Chen   +6 more
semanticscholar   +1 more source