Frontiers in Immunology, 2021 Granzyme B is a renowned effector molecule primarily utilized by CTLs and NK cells against ill-defined and/or transformed cells during immunosurveillance.
Jishuang Liu, Ye Qiu, Qiu Zhidong
exaly +3 more sources
BMC Genomics, 2011 Background Granzyme B is a serine protease which cleaves at unique tetrapeptide sequences. It is involved in several signaling cross-talks with caspases and functions as a pivotal mediator in a broad range of cellular processes such as apoptosis and ...
Wee Lawrence JK +3 more
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Changes in Cell-Mediated Immunity (IFN-γ and Granzyme B) Following Influenza Vaccination
Viruses, 2021 Interferon gamma (IFN-γ) is considered a key moderator of cell-mediated immunity. However, little is known about its association with granzyme B, which plays an important role in the effector function of cytotoxic T lymphocytes (CTLs).
Naruhito Otani +2 more
exaly +3 more sources
Granzyme B in Autoimmune Skin Disease
Biomolecules, 2023 Autoimmune diseases often present with cutaneous symptoms that contribute to dysfunction, disfigurement, and in many cases, reduced quality-of-life. Unfortunately, treatment options for many autoimmune skin diseases are limited.
Anna Gleave, David J. Granville
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Granzyme B PET Imaging of the Innate Immune Response
Molecules, 2020 The human immune system is a complex system which protects against invaders and maintains tissue homeostasis. It is broadly divided into the innate and adaptive branches. Granzyme B is serine protease that plays an important role in both and can serve as
Mikhail Doubrovin +2 more
exaly +3 more sources
Development of a novel 18F-labeled radiotracer targeting granzyme B for imaging early tumor responses to immunotherapy [PDF]
Journal for ImmunoTherapy of CancerBackground Immunotherapy has emerged as a promising avenue for malignant tumors treatment, but methods to validate its in vivo antitumor activity remain limited.
Xiao Wang +4 more
doaj +2 more sources
Aberrant intra‐epithelial lymphocytes cause enterocyte cell death in refractory celiac disease by CD103‐β7‐receptor‐mediated granzyme‐B degranulation which can be restored by etrolizumab [PDF]
Clinical & Translational ImmunologyObjectives Refractory celiac disease type II (RCDII) is an intestinal tumor of aberrant intra‐epithelial T‐lymphocytes (IEL). The severe enteropathy found in RCDII is caused by aberrant IEL that exert cytotoxicity against enterocytes.
Daan A R Castelijn +18 more
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Induction Therapies Determine the Distribution of Perforin and Granzyme B Transcripts in Kidney Transplant Recipients [PDF]
BiomedicinesPeripheral blood mononuclear cells contain secretory granules with Perforin and Granzyme B for defense against pathogens. The objective of the present study was to compare the effects of immunosuppressive induction therapies on Perforin and Granzyme B ...
Dino Pipic +3 more
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Diagnostic Efficacy and Clinical Significance of Lymphocyte Subsets, Granzyme B and Perforin in the Peripheral Blood of Patients with Invasive Breast Cancer Following Neoadjuvant Chemotherapy [PDF]
Cancer Management and ResearchPurpose: Breast cancer, a predominant contributor to cancer-related mortality worldwide, is increasingly managed through the application of neoadjuvant chemotherapy (NAC).
Liu H +6 more
doaj +2 more sources
Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice. [PDF]
PLoS ONE, 2012 Pancreatic beta cell destruction in type 1 diabetes is mediated by cytotoxic CD8(+) T lymphoctyes (CTL). Granzyme B is an effector molecule used by CTL to kill target cells.
Zia U Mollah +7 more
doaj +1 more source