Results 31 to 40 of about 52,710 (257)

Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β

Journal of Neuroinflammation, 2017
Background The cause of neurodegeneration in progressive forms of multiple sclerosis is unknown. We investigated the impact of specific neuroinflammatory markers on human neurons to identify potential therapeutic targets for neuroprotection against ...
Paul R. Lee, Tory P. Johnson, Sharmilee Gnanapavan, Gavin Giovannoni, Tongguang Wang, Joseph P. Steiner, Marie Medynets, Mark J. Vaal, Valerie Gartner, Avindra Nath   +9 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells

Frontiers in Cell and Developmental Biology, 2021
Mast cells are multifunctional immune cells scattered in tissues near blood vessels and mucosal surfaces where they mediate important reactions against parasites and contribute to the pathogenesis of allergic reactions.
Sabrina Sofia Burgener, Sabrina Sofia Burgener, Melanie Brügger, Melanie Brügger, Melanie Brügger, Nathan Georges François Leborgne, Nathan Georges François Leborgne, Sophia Sollberger, Sophia Sollberger, Paola Basilico, Paola Basilico, Thomas Kaufmann, Phillip Ian Bird, Charaf Benarafa, Charaf Benarafa   +14 more
doaj   +1 more source

Administering Blinatumomab via Continuous Intravenous Infusion in Pediatric Patients—A Single‐Institution Retrospective Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab, a CD19xCD3 bispecific T‐cell engager, has become standard therapy for children with de novo B‐cell acute lymphoblastic leukemia (B‐ALL). This retrospective review describes the experience of blinatumomab administration in pediatric patients.
Julia M. Hurley, Ryleigh Krueger, Kellie Joyce, James Stanley, Mary Waskerwitz‐Freyer, Marielle Klunder, David J. Hoogstra   +6 more
wiley   +1 more source

Granzyme B; the chalk-mark of a cytotoxic lymphocyte

Journal of Translational Medicine, 2004
During cytotoxic lymphocyte (CL) mediated killing of target cells, granzyme B is released from the CL into the immune synapse. Recent studies have found that ELISPOT-detection of granzyme B correlated well with conventional assays for CL mediated killing.
Clarke Chris JP, Sedelies Karin A, Waterhouse Nigel J   +2 more
doaj   +1 more source

Overrepresentation of IL-10-Expressing B Cells Suppresses Cytotoxic CD4+ T Cell Activity in HBV-Induced Hepatocellular Carcinoma. [PDF]

PLoS ONE, 2016
Hepatocellular carcinoma (HCC) is a common cancer with poor prognosis and low five-year survival rate. A strong and effective CD4+ T cell-mediated cytotoxicity was associated with better survival and low recurrence rate in HCC, but the regulatory ...
Hongwei Xue, Fuhuang Lin, Hongwu Tan, Zun-Qiang Zhu, Zhang-Yun Zhang, Ludong Zhao   +5 more
doaj   +1 more source

NK- and T-cell granzyme B and K expression correlates with age, CMV infection and influenza vaccine-induced antibody titres in older adults

Frontiers in Aging, 2023
Granzymes are a family of serine-proteases that act as critical mediators in the cytolytic and immunomodulatory activities of immune cells such as CD8+ T-cells and natural killer (NK) cells.
Chris P. Verschoor, Chris P. Verschoor, Emilie Picard, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, Graham Pawelec, George A. Kuchel   +8 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Association between serum granzyme B and clinical features of atopic dermatitis:A crosssectional study

Pifu-xingbing zhenliaoxue zazhi
Objective To assess the serum granzyme B levels in patients with atopic dermatitis, and to analyze their association with disease severity and clinical characteristics.
ZHANG Qian, LIU Jie, ZHANG Lixia
doaj   +1 more source

Granzyme B levels and granzyme B polymorphisms in peripheral blood of patients with endometriosis: a preliminary study

Journal of Obstetrics and Gynaecology, 2020
The chronic course of endometriosis suggests that the immune system may play a role in its aetiology. There may be resistance to cell lysis, as well as an immune defect underlying endometriosis. Granzyme B is a serine protease that is secreted by Natural Killer (NK) cells and cytotoxic T lymphocytes during a cellular immune response and can induce ...
Mine Islimye Taskin, Gurhan Guney, Ertan Adali, Adnan Adil Hismiogullari, Yavuz Dodurga, Levent Elmas   +5 more
openaire   +5 more sources