Results 1 to 10 of about 50 (46)

Intracellular and Extracellular Roles of Granzyme K [PDF]

Frontiers in Immunology, 2021
Granzymes are a family of serine proteases stored in granules inside cytotoxic cells of the immune system. Granzyme K (GrK) has been only limitedly characterized and knowledge on its molecular functions is emerging. Traditionally GrK is described as a granule-secreted, pro-apoptotic serine protease.
Annemieke C. Bouwman, Kim R. van Daalen, Sandra Crnko, Toine ten Broeke, Niels Bovenschen, Niels Bovenschen   +5 more
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Residual Cytotoxicity and Granzyme K Expression in Granzyme A-deficient Cytotoxic Lymphocytes [PDF]

Journal of Biological Chemistry, 1997
Cytotoxic lymphocytes contain granules that have the ability to induce apoptosis in susceptible target cells. The granule contents include perforin, a pore-forming molecule, and several granzymes, including A and B, which are the most abundant serine proteases in these granules. Granzyme B-deficient cytotoxic T lymphocytes (CTL) have a severe defect in
S, Shresta, P, Goda, R, Wesselschmidt, T J, Ley   +3 more
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Granzyme K Displays Highly Restricted Substrate Specificity That Only Partially Overlaps with Granzyme A [PDF]

Journal of Biological Chemistry, 2009
Granzymes are serine proteases stored in cytolytic granules of cytotoxic lymphocytes that eliminate virus-infected and tumor cells. Little is known about the molecular mechanism and function of granzyme (Gr)K. GrK is similar to GrA in that they are the only granzymes that display tryptase-like activity.
Niels, Bovenschen, Razi, Quadir, A Lotte, van den Berg, Arjan B, Brenkman, Isabel, Vandenberghe, Bart, Devreese, Jos, Joore, J Alain, Kummer   +7 more
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Granzyme K: a novel mediator in acute airway inflammation [PDF]

Thorax, 2008
Granzymes are a subfamily of serine proteases involved in the pathogenesis of many inflammatory disorders. In contrast with granzyme A and B, the role of granzyme K (GrK) in human lung diseases is unknown. Therefore, the release and expression of GrK in allergic asthma, chronic obstructive pulmonary disease (COPD) and bronchopneumonia were investigated.
K, Bratke, A, Klug, P, Julius, M, Kuepper, M, Lommatzsch, G, Sparmann, W, Luttmann, J C, Virchow   +7 more
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Testosterone regulates granzyme K expression in rat testes [PDF]

Endocrine Regulations, 2017
AbstractObjective. Testosterone depletion induces increased germ cell apoptosis in testes. However, limited studies exist on genes that regulate the germ cell apoptosis. Granzymes (GZM) are serine proteases that induce apoptosis in various tissues. Multiple granzymes, including GZMA, GZMB and GZMN, are present in testes.
Dutta Dibyendu, Park In, Guililat Hiwot, Sang Samuel, Talapatra Arpita, Singhal Barkha, Mills Nathaniel C.   +6 more
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Mouse granzyme K has pro-inflammatory potential [PDF]

Cell Death & Differentiation, 2011
Granzymes (gzms) are key components of T-killer (Tc) cells believed to mediate pro-apoptotic activities. Recent evidence suggests that gzms also possess non-cytotoxic activities that contribute to host defense. In this study, we show that Tc cells from lymphocytic choriomeningitis virus (LCMV)-infected wild-type (wt) and gzm A/B-deficient mice express ...
Jöckel, Lars, Wallich, Reinhard, Martin, Pilar, Sanchez-Martinez, D., Weber, Felix C., Martin, Stefan F., Borner, Christoph, Pardo, Jordi Pardo, Froelich, Christopher J., Simon, Markus M.   +9 more
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Generation of Catalytically Active Granzyme K from Escherichia coli Inclusion Bodies and Identification of Efficient Granzyme K Inhibitors in Human Plasma [PDF]

Journal of Biological Chemistry, 1999
Granzymes are granule-stored lymphocyte serine proteases that are implicated in T- and natural killer cell-mediated cytotoxic defense reactions after target cell recognition. A fifth human granzyme (granzyme 3, lymphocyte tryptase-2), renamed as granzyme K (gene name GZMK), has recently been cloned from lymphocyte tissue.
Wilharm, E, Parry, MAA, Friebel, R, Tschesche, Harald, Matschiner, G, Sommerhoff, CP, Jenne, DE   +6 more
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Taa Cells and Granzyme K: Old Players with New Tricks [PDF]

Immunity, 2021
Inflammaging is associated with chronic diseases, but tissue-specific changes in the immune system remain unknown. In this issue of Immunity, Mogilenko et al. use single-cell RNA sequencing, flow cytometry, and mass cytometry to describe age-related differences, including the accumulation of age-associated T cells that contribute to inflammaging.
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Granzyme M and K release in human experimental endotoxemia

Immunobiology, 2016
Granzymes are serine proteases involved in killing of tumor cells and virally infected cells. However, granzymes are also upregulated in blood under inflammatory conditions and contribute to cytokine release and processing. Here, we show that granzyme M (GrM) and to a lesser extent GrK are transiently elevated in the circulation following LPS ...
Wensink, Annette C., Wiewel, Maryse A., Jongeneel, Lieneke H., Boes, Marianne, van der Poll, Tom, Hack, C. Erik, Bovenschen, Niels   +6 more
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Biological relevance of Granzymes A and K during E. coli sepsis

Theranostics, 2021
Aims: Recent in vitro findings suggest that the serine protease Granzyme K (GzmK) may act as a proinflammatory mediator. However, its role in sepsis is unknown. Here we aim to understand the role of GzmK in a mouse model of bacterial sepsis and compare it to the biological relevance of Granzyme A (GzmA).
Uranga-Murillo I., Tapia E., Garzón-Tituaña M., Ramirez-Labrada A., Santiago L., Pesini C., Esteban P., Roig F.J., Galvez E.M., Bird P.I., Pardo Jimeno, J., Arias M.   +11 more
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