Results 31 to 40 of about 149 (110)

Granzyme K mediates IL-23-dependent inflammation and keratinocyte proliferation in psoriasis

Frontiers in Immunology
Psoriasis is an inflammatory disease with systemic manifestations that most commonly presents as itchy, erythematous, scaly plaques on extensor surfaces.
Katlyn C. Richardson, Katlyn C. Richardson, Katlyn C. Richardson, Alexandre Aubert, Alexandre Aubert, Alexandre Aubert, Christopher T. Turner, Christopher T. Turner, Christopher T. Turner, Layla Nabai, Layla Nabai, Layla Nabai, Sho Hiroyasu, Sho Hiroyasu, Sho Hiroyasu, Megan A. Pawluk, Megan A. Pawluk, Megan A. Pawluk, Rachel A. Cederberg, Rachel A. Cederberg, Hongyan Zhao, Hongyan Zhao, Hongyan Zhao, Karen Jung, Karen Jung, Karen Jung, Angela Burleigh, Richard I. Crawford, Richard I. Crawford, David J. Granville, David J. Granville, David J. Granville   +31 more
doaj   +1 more source

The Transcriptional Differences of Avian CD4+CD8+ Double-Positive T Cells and CD8+ T Cells From Peripheral Blood of ALV-J Infected Chickens Revealed by Smart-Seq2

Frontiers in Cellular and Infection Microbiology, 2021
It is well known that chicken CD8+ T cell response is vital to clearing viral infections. However, the differences between T cell subsets expressing CD8 receptors in chicken peripheral blood mononuclear cells (PBMCs) have not been compared.
Manman Dai, Li Zhao, Ziwei Li, Xiaobo Li, Bowen You, Sufang Zhu, Ming Liao   +6 more
doaj   +1 more source

Single-cell profiling reveals pathogenic role and differentiation trajectory of granzyme K+CD8+ T cells in primary Sjögren’s syndrome

JCI Insight, 2023
Primary Sjögren’s syndrome (pSS) is a systemic autoimmune inflammatory disease mainly defined by T cell–dominated destruction of exocrine glands. Currently, CD8+ T cells are thought to be involved in the pathogenesis of pSS.
Ting Xu, Hao-Xian Zhu, Xing You, Jin-Fen Ma, Xin Li, Pan-Yue Luo, Yang Li, Zhe-Xiong Lian, Cai-Yue Gao   +8 more
doaj   +1 more source

Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity

Frontiers in Immunology, 2023
Granzymes A and K are two highly homologous serine proteases expressed by mammalian cytotoxic T cells (CTL) and natural killer cells (NK). Granzyme A is the most abundant of the different granzymes (gzms) expressed by these two cell types.
Erdem Aybay, Jinhye Ryu, Zhirong Fu, Srinivas Akula, Srinivas Akula, Erika Mendez Enriquez, Jenny Hallgren, Sara Wernersson, Anna-Karin Olsson, Lars Hellman   +9 more
doaj   +1 more source

Gzmk+ CD8 T cells in inflammatory diseases

Frontiers in Immunology
T cells are integral to the immune response, with distinct subsets exhibiting specialized functions, a phenomenon well-characterized in helper CD4+ T cells. Recent advancements in single-cell RNA sequencing (scRNA-seq) have facilitated the identification
Cui Xin, Peiyun Liu, Qianqian Zhan, Wenqiang Cao   +3 more
doaj   +1 more source

Granzyme K provides protection for Nile tilapia (Oreochromis niloticus) from acute bacterial infection.

Aquaculture Reports
Granzyme K (GzmK) is a trypsin-like serine protease that functions as a pro-apoptotic protease, has non-cytotoxic functions, and is involved in various physiopathological processes.
Xing Li, Zhiqiang Zhang, Baijian Jiang, Meiling Huang, Jiamin Feng, Yongxiong Huang, Kwaku Amoah, Berchie Asiedu, Yu Huang, Jichang Jian   +9 more
doaj   +1 more source

Biological activities of granzyme K are conserved in the mouse and account for residual Z‐Lys‐SBzl activity in granzyme A‐deficient mice

FEBS Letters, 1999
Tryptase‐like activities of T and NK cells contribute to the induction of target cell apoptosis, but only granzyme A (GzmA) has been shown to exhibit Z‐Lys‐SBzl esterase activity in murine T cells. GzmA‐deficient mice exhibit residual Z‐Lys‐SBzl hydrolyzing activity and almost normal levels of lymphocyte‐mediated cytotoxicity.
Wilharm, E., Tschopp, J., Jenne, D.
openaire   +3 more sources

KLRG1 defines a distinct tumor-infiltrating granzyme K+ CD8 + T cell population

Journal of Cancer Research and Clinical Oncology
Purpose Emerging evidence indicates that granzyme K expressing tumor infiltrating CD8 + T-cells play a critical role in mediating anti-tumor T-cell immunity and immunotherapy treatment response.
Jerin Thomas, Sophia Kennedy, Stella Darcy, Henrique Malaco, Nyasha Chambwe, Dev Kamdar, Lucio Periera, Andrew Salama, Danielle Scarola, Brett Miles, Douglas Frank, Nagashree Seetharamu, Rajarsi Mandal   +12 more
doaj   +1 more source

Ignition of p53 Bomb Sensitizes Tumor Cells to Granzyme K-Mediated Cytolysis [PDF]

The Journal of Immunology, 2009
Abstract Inactivation of tumor suppressor p53 results in loss of the apoptosis-regulating function of the p53 protein in tumor cells. Restoration of wild-type p53 expression in p53 mutant tumor cells increases tumor susceptibility to CTL-mediated cytolysis.
Guoqiang, Hua, Shuo, Wang, Chao, Zhong, Peng, Xue, Zusen, Fan   +4 more
openaire   +2 more sources

Granzyme K Expressed by Classically Activated Macrophages Contributes to Inflammation and Impaired Remodeling [PDF]

Journal of Investigative Dermatology, 2019
Granzyme K (GzmK), traditionally described as a pro-apoptotic, granule-secreted serine protease, has been proposed to promote inflammation. Found at low levels in the plasma of healthy individuals, GzmK is markedly elevated in response to sepsis and infection.
Christopher T. Turner, Matthew R. Zeglinski, Katlyn C. Richardson, Hongyan Zhao, Yue Shen, Anthony Papp, Phillip I. Bird, David J. Granville   +7 more
openaire   +2 more sources