Results 51 to 60 of about 149 (110)

Granzyme B cleaves tenascin-C to release its C-terminal domain in rheumatoid arthritis

JCI Insight
Rheumatoid arthritis (RA) is a common autoimmune disorder characterized by exacerbated joint inflammation. Despite the well-documented accumulation of the serine protease granzyme B (GzmB) in RA patient biospecimens, little is understood pertaining to ...
Alexandre Aubert, Amy Liu, Martin Kao, Jenna Goeres, Katlyn C. Richardson, Lorenz Nierves, Karen Jung, Layla Nabai, Hongyan Zhao, Gertraud Orend, Roman Krawetz, Philipp F. Lange, Alastair Younger, Jonathan Chan, David J. Granville   +14 more
doaj   +1 more source

Divergent cytotoxic and inflammatory functions of intratumoral Vδ2+ γδ T cells in renal cell carcinoma

Frontiers in Immunology
Vγ9Vδ2 T cells are blood-circulating, innate-like lymphocytes that contribute to tumor immunosurveillance and constitute over 95% of Vδ2+ γδ T cells, but how they perform antitumor or protumor functions remains unclear.
Won Joon Oh, Won Joon Oh, Jaeyoun Park, Jaeyoun Park, Tilanka Kalanapriya Dahanayake, Tilanka Kalanapriya Dahanayake, Seon Yong Yeom, Seon Yong Yeom, Heeju Ryu, Heeju Ryu, Seong Il Seo, Seong Il Seo, Tae Jin Kim, Tae Jin Kim   +13 more
doaj   +1 more source

Granzyme K drives a newly-intentified pathway of complement activation

Abstract Granzymes are a family of serine proteases mainly expressed by CD8 + T cells, natural killer cells, and innate-like lymphocytes 1,2 . Although their major role is thought to be the induction of cell death in virally infected and tumor ...
Carlos A. Donado, A. Helena Jonsson, Erin Theisen, Fan Zhang, Aparna Nathan, Karishma Vijay Rupani, Dominique Jones, Soumya Raychaudhuri, Daniel F. Dwyer, Michael B. Brenner   +9 more
openaire   +2 more sources

Tumor infiltrating lymphocytes in glioblastoma: immunobiology and translational implications

npj Precision Oncology
Glioblastoma (GBM) poses unique challenges to immunotherapy, owing to its low tumor mutational burden, profound antigenic heterogeneity, and highly immunosuppressive microenvironment.
Cameron M. Hill, Chibueze D. Nwagwu, Angel O. Odukoya, Brian Hsueh, Anthony Z. Wang, Gavin P. Dunn   +5 more
doaj   +1 more source

Focal Molography Allows for Affinity and Concentration Measurements of Proteins in Complex Matrices with High Accuracy

Biosensors
Characterizing biomolecular receptor–ligand interactions is critical for research and development. However, performing analyses in complex, biologically relevant matrices, such as serum, remains challenging due to non-specific binding that often impairs ...
Lorin Dirscherl, Laura S. Merz, Ronya Kobras, Peter Spies, Andreas Frutiger, Volker Gatterdam, Dominik M. Meinel   +6 more
doaj   +1 more source

081 Granzyme K: A potential mediator of psoriasis [PDF]

Journal of Investigative Dermatology, 2020
K. Richardson, C. Turner, S. Hiroyasu, R. Crawford, A. Burleigh, D. Granville   +5 more
openaire   +1 more source

The role of CD8+ T cells in the immunoregulation of osteoporosis

Frontiers in Immunology
IntroductionOsteoporosis weakens the skeleton by lowering bone mass and damaging bone microarchitecture. A growing body of evidence points to disruptions in osteoimmune homeostasis as a key driver of this disease.
ZiChao Chen, Hao Hu, Die Hu, QinChuan Du, HuanZhi Yang, RongHua Xu, Peng Yu, XingBo Hu, Jun Hu   +8 more
doaj   +1 more source

Characterization of double-negative T cells in colorectal cancers and their corresponding lymph nodes

OncoImmunology
TCRαβ+ CD4− CD8− double-negative T (DNT) cells are minor populations in peripheral blood, and their roles have mostly been discussed in inflammation and autoimmunity.
Kazumi Okamura, Lifang Wang, Satoshi Nagayama, Makiko Yamashita, Tomohiro Tate, Saki Matsumoto, Manabu Takamatsu, Shigehisa Kitano, Kazuma Kiyotani, Yusuke Nakamura   +9 more
doaj   +1 more source

Differentiation-induced reduction in functional diversity restricts the ability of cytomegalovirus-specific CD8 T cells to eliminate virus-infected cellsResearch in context

EBioMedicine
Summary: Background: Human cytomegalovirus (HCMV) is one of the pathogens with the most significant impact on the immune system's composition, including the expansion of virus-specific CD8 T cells.
Lea Fritz, Ahmed Hassan, Lennart Riemann, Berislav Čuvalo, Bibiana Costa, Britta Wieland, Britta Eiz-Vesper, Christine Falk, Lennart M. Roesner, Thomas Werfel, Ulrich Kalinke, Hristo Georgiev, Reinhold Förster, Berislav Bošnjak   +13 more
doaj   +1 more source

418 CD8+ T-cell transfer induces adverse alterations to the post-myocardial infarction scar

Journal of Clinical and Translational Science
Objectives/Goals: Cardiovascular disease, particularly myocardial infarction (MI), is a leading cause of death in the USA. Previous studies have identified CD8+ T-cells as adverse regulators post-MI.
Shaoni Dasgupta, Maya Learnmonth, Alexa Corker, Miguel Troncoso, Ralph H. Johnson Veterans, Philip Broughton, Catalin F. Baicu, D. Bradshaw, Carolina Kristine Y. DeLeon-Pennell   +8 more
doaj   +1 more source