Results 61 to 70 of about 149 (110)

Discovery of Small-Molecule PD-L1 Inhibitors via Virtual Screening and Their Immune-Mediated Anti-Tumor Effects

Pharmaceuticals
Background/Objectives: Monoclonal antibodies targeting the PD-1/PD-L1 immune checkpoint have achieved clinical success but face drawbacks such as poor oral bioavailability, limited tumor penetration, and immune-related adverse events.
Chunlai Feng, Yingying Ge, Siqi Wang, Mengru Li, Qiying Chen, Hangyu Dong, Mengjie Rui   +6 more
doaj   +1 more source

Cytotoxic Molecules as Potential Biomarkers for Active and Inactive Systemic Lupus Erythematosus

Biomedicines
Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by persistent inflammation. Reliable biomarkers for predicting disease reactivation are lacking.
Paola Santana-Sánchez, Astrid Asminda Ramírez-Pérez, Paolo Alberti-Minutti, Julián A. Gajón, Laura C. Bonifaz, Norberto Sánchez-Escobar, María Victoria Legorreta-Haquet, Luis Chávez-Sánchez, Adriana Karina Chávez-Rueda   +8 more
doaj   +1 more source

Single-Cell Analysis Identifies Distinct Populations of Cytotoxic CD4+ T Cells Linked to the Therapeutic Efficacy of Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma

Journal of Inflammation Research
Xu Yang,1,* Jianwei Wu,1,* Longlong Fan,2 Binghua Chen,3 Shiqiang Zhang,4 Wenzhong Zheng1 1Department of Urology, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of China; 2Department of Urology, The Eighth Affiliated Hospital,
Yang X, Wu J, Fan L, Chen B, Zhang S, Zheng W   +5 more
doaj  

KCa3.1 channels regulate the tumor infiltration of functionally competent NK cells in head and neck cancer

Scientific Reports
CD8+ T cells and natural killer (NK) cells are the primary defenses against tumor cells. The tumor microenvironment impairs their antitumor capabilities, including the ability to infiltrate the tumor. Our laboratory has shown that tumors suppress T cells
Abdulaziz O. Alshwimi, Ameet A. Chimote, Marat V. Khodoun, Layne Weatherford, Benjamin H. Hinrichs, Heike Wulff, Stephen N. Waggoner, Trisha M. Wise-Draper, Laura Conforti   +8 more
doaj   +1 more source

Granzyme K sets complement in motion

Kidney International
Felix Poppelaars, Mohamed R. Daha
openaire   +3 more sources

A new member at the table: Granzyme K as a lymphocyte‐born complement initiator

Clinical and Translational Discovery
Manoj Kumar Pandey
doaj   +1 more source

Research Progress on the Regulatory Role of Granzyme-K in Hypertension

Advances in Clinical Medicine
openaire   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Substrate Specificities of the Granzyme Tryptases A and K

Journal of Proteome Research, 2014
The physiological roles of the granzymes A and K have been debated, especially concerning their involvement in cytotoxic and inflammatory processes. By performing N-terminal COFRADIC assisted N-terminomics on the homologous human granzymes A and K, we here provide detailed data on their substrate repertoires, their specificities, and differences in ...
Kim, Plasman, Hans, Demol, Philip I, Bird, Kris, Gevaert, Petra, Van Damme   +4 more
openaire   +2 more sources

DDVP markedly decreases the expression of granzyme B and granzyme 3/K in human NK cells

Toxicology, 2008
Natural killer (NK), lymphokine-activated killer (LAK), and cytotoxic T lymphocyte (CTL) cells kill target cells by the directed release of cytolytic granules that contain perforin, granzymes, and granulysin. We have found previously that dimethyl 2,2-dichlorovinyl phosphate (DDVP, dichlorvos), an organophosphorus pesticide, significantly decreased the
Qing, Li, Maiko, Kobayashi, Tomoyuki, Kawada   +2 more
openaire   +2 more sources

Granzyme K activates the entire complement cascade

Nature
Granzymes are a family of serine proteases that are mainly expressed by CD8+ T cells, natural killer cells and innate-like lymphocytes1. Although their primary function is thought to be the induction of cell death in virally infected cells and tumours, accumulating evidence indicates that some granzymes can elicit inflammation by acting on ...
Carlos A. Donado, Erin Theisen, Fan Zhang, Aparna Nathan, Madison L. Fairfield, Karishma Vijay Rupani, Dominique Jones, Kellsey P. Johannes, Jennifer Albrecht, Jennifer H. Anolik, William Apruzzese, Jennifer L. Barnas, Joan M. Bathon, Ami Ben-Artzi, Brendan F. Boyce, David L. Boyle, S. Louis Bridges, Vivian P. Bykerk, Debbie Campbell, Arnold Ceponis, Adam Chicoine, Michelle Curtis, Kevin D. Deane, Edward DiCarlo, Laura T. Donlin, Patrick Dunn, Andrew Filer, Hayley Carr, Gary S. Firestein, Lindsy Forbess, Laura Geraldino-Pardilla, Susan M. Goodman, Ellen M. Gravallese, Deepak Rao, Peter K. Gregersen, Joel M. Guthridge, Maria Gutierrez-Arcelus, V. Michael Holers, Diane Horowitz, Laura B. Hughes, Lionel B. Ivashkiv, Kazuyoshi Ishigaki, Judith A. James, Joyce B. Kang, Gregory Keras, Amit Lakhanpal, James A. Lederer, Miles J. Lewis, Yuhong Li, Katherine Liao, Arthur M. Mandelin, Ian Mantel, Kathryne E. Marks, Mark Maybury, Andrew McDavid, Mandy J. McGeachy, Joseph R. Mears, Nida Meednu, Nghia Millard, Larry Moreland, Saba Nayar, Alessandra Nerviani, Dana E. Orange, Harris Perlman, Costantino Pitzalis, Javier Rangel-Moreno, Karim Raza, Yakir Reshef, Christopher Ritchlin, Felice Rivellese, William H. Robinson, Laurie Rumker, Ilfita Sahbudin, Saori Sakaue, Jennifer A. Seifert, Dagmar Scheel-Toellner, Anvita Singaraju, Kamil Slowikowski, Melanie Smith, Darren Tabechian, Paul J. Utz, Kathryn Weinand, Dana Weisenfeld, Michael H. Weisman, Qian Xiao, Zhu Zhu, Zhihan J. Li, Andrew Cordle, Aaron Wyse, Soumya Raychaudhuri, Daniel F. Dwyer, A. Helena Jonsson, Michael B. Brenner   +92 more
openaire   +2 more sources