Results 71 to 80 of about 149 (110)

Granzyme K Expressing Cytotoxic T Lymphocytes Protects Against Influenza Virus in Granzyme AB ^−/− Mice

Viral Immunology, 2008
Granzyme (grz) AB(-/-) H2(b) mice generate numerically normal cytotoxic T lymphocyte (CTL) responses to the prominent influenza A virus D(b) NP(366) and D(b) PA(224) epitopes and terminate the infectious process in the pneumonic lung with the same kinetics as the WT controls. Though grz B protein expression is fully compromised, there is only a partial
Misty R, Jenkins, Joseph A, Trapani, Peter C, Doherty, Stephen J, Turner   +3 more
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Granzyme K+ CD8 T cells in autoimmunity

Best Practice & Research Clinical Rheumatology
CD8 T cells expressing granzyme K are enriched in synovial tissue from patients with rheumatoid arthritis and in tissues affected by several other autoimmune diseases. The roles these cells play in autoimmune disease is under active investigation, and several recent studies have begun to shed light on this question.
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Granzyme K‐deficient mice show no evidence of impaired antiviral immunity

Immunology & Cell Biology, 2017
The biological role of granzyme K, a serine protease of cytotoxic T lymphocytes (CTL), is controversial. It has been reported to induce perforin‐mediated cell death in vitro, but is also reported to be non‐cytotoxic and to operate in inflammatory processes.
Lars T, Joeckel, Cody C, Allison, Marc, Pellegrini, Catherina H, Bird, Phillip I, Bird   +4 more
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ALTERED LEVELS AND MOLECULAR FORMS OF GRANZYME K IN PLASMA FROM SEPTIC PATIENTS

Shock, 2007
Granzyme K (GrK) is a member of a highly conserved group of potent serine proteases specifically found in the secretory granules of cytotoxic T lymphocytes and natural killer cells. Based on the report indicating that inter-alpha inhibitor proteins are the physiological inhibitors of GrK and on previous findings that showed a significant decrease in ...
Ručević, Marijana, Fast, Loren D., Jay, Gregory D., Trespalcios, Flor M., Sucov, Andrew, Siryaporn, Edward, Lim, Yow-Pin   +6 more
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Granzyme K : a novel contributor in cardiac allograft vasculopathy

2020
Background - A major factor limiting survival for patients that have undergone cardiac transplantation is cardiac allograft vasculopathy (CAV). CAV is a fibroproliferative inflammatory form of vascular rejection mediated by immune cells and which is initiated upon damage to the graft endothelium and medial smooth muscle cells (SMC).
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The Role of Granzyme K in Inflammatory Response

2006
Granzyme K is one of a family of serine proteases found in the granules of murine and human NK cells and cytolytic T lymphocytes (CTL). We had observed that decreased levels of inter- -inhibitor proteins, the putative inhibitor of granzyme K, correlated with increased mortality in sepsis.
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The Effect of Cytokines on Granzyme K and Granzyme B Expression in CD8+ T Cells

2020
Master of Medical Sciences in ...
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Extracellular granzyme B and K are associated with endometriosis severity in infertile women

Cytokine
Endometriosis is a chronic inflammatory condition often associated with infertility. The role of granzymes as cytotoxic proteases and immune regulators in endometriosis remains poorly understood. This study evaluated serum and peritoneal fluid levels of granzymes A, B, and K in women with endometriosis and their links to disease severity.An ...
Fadhil, Ahsan, Budi, Santoso, Nanda Yuli, Rahmawati, Fidyah Nanda, Alditia, Alfin Firasy, Mufid, M Y Ardianta, Widyanugraha, Ashon, Sa'adi, Sri Ratna, Dwiningsih, Arif, Tunjungseto   +8 more
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Granzyme K : a novel therapeutic target for psoriasis

The full abstract for this thesis is available in the body of the thesis, and will be available when the embargo expires.
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Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia

Nature Immunology
Neurodegenerative diseases activate innate and adaptive immune responses that can either slow or accelerate disease progression. Here, we sought to define beneficial immune pressures that emerge during tauopathy development in mice and humans. Using mice that express mutant human tau in neurons, we observed that microglia slowed tauopathy development ...
Hannah D. Mason, Yvonne L. Latour, Christopher T. Boughter, Kory R. Johnson, Dragan Maric, Cayce E. Dorrier, Vivian A. Guedes, Chen Lai, Patrick C. Duncker, Alexis M. Johnson, Monica Manglani, Jessica M. Gill, Daniel P. Perl, Martin Meier-Schellersheim, Dorian B. McGavern   +14 more
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