Results 41 to 50 of about 149 (110)

Single‐Cell RNA Sequencing Reveals Granzyme K+ CD8+ T Cells as a Target for Mitigating Plaque Instability Following Radiation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiac issues following radiotherapy are increasingly prevalent among patients with thoracic cancer and coronary disease. However, the mechanisms underlying radiotherapy‐induced plaque instability and changes in plaque characteristics on ...
Manru Shi, Quan Lin, Shaohong Fang, Cheng Ma, Weiwei Xu, Di Sun, Naixin Wang, Jingxuan Cui, Zhonghua Tong, Yuwu Chen, Xing Luo, Sining Hu, Tuo Huang, Yunlong He, Yang Cao, Jiayin Liu, Jiaqi Li, Anxin Gu, Xiuwen Lan, Meng Chi, Chao Wang, Jiaqi Gu, Siqi Tian, Jiaao Liu, Zixuan Liu, Maomao Zhang, Mingyan E   +26 more
doaj   +1 more source

High OX-40 expression in the tumor immune infiltrate is a favorable prognostic factor of overall survival in non-small cell lung cancer

Journal for ImmunoTherapy of Cancer, 2019
Introduction OX-40 co-stimulatory signaling plays a role in mounting anti-tumor immune responses and clinical trials targeting this pathway are ongoing.
Erminia Massarelli, Vincent K. Lam, Edwin R. Parra, Jaime Rodriguez-Canales, Carmen Behrens, Lixia Diao, Jing Wang, Jorge Blando, Lauren A. Byers, Niranjan Yanamandra, Sara Brett, Peter Morley, Padmanee Sharma, James Allison, Ignacio I. Wistuba, John V. Heymach   +15 more
doaj   +1 more source

A Single-Cell Landscape of Human Liver Transplantation Reveals a Pathogenic Immune Niche Associated with Early Allograft Dysfunction

Engineering
Liver transplantation (LT) is the standard therapy for individuals afflicted with end-stage liver disease. Despite notable advancements in LT technology, the incidence of early allograft dysfunction (EAD) remains a critical concern, exacerbating the ...
Xin Shao, Zheng Wang, Kai Wang, Xiaoyan Lu, Ping Zhang, Rongfang Guo, Jie Liao, Penghui Yang, Shusen Zheng, Xiao Xu, Xiaohui Fan   +10 more
doaj   +1 more source

Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Journal of Translational Medicine, 2011
Background Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is characterised by severe prolonged fatigue, and decreases in cognition and other physiological functions, resulting in severe loss of quality of life, difficult clinical management ...
Ashton Kevin J, Staines Don R, van Driel Mieke L, Brenu Ekua W, Ramos Sandra B, Keane James, Klimas Nancy G, Marshall-Gradisnik Sonya M   +7 more
doaj   +1 more source

CD103–CD8+ T cells promote neurotoxic inflammation in Alzheimer’s disease via granzyme K–PAR-1 signaling

Nature Communications
Immune mechanisms contribute to the neuropathology of Alzheimer’s disease (AD) but the role of adaptive immune cells is unclear. Here we show that the brain CD8+ T cell compartment is dysregulated in AD patients and in the 3xTg-AD mouse model ...
Eleonora Terrabuio, Enrica Caterina Pietronigro, Alessandro Bani, Vittorina Della Bianca, Carlo Laudanna, Barbara Rossi, Giulia Finotti, Bruno Santos-Lima, Elena Zenaro, Ermanna Turano, Gabriele Tosadori, Matteo Calgaro, Nicola Vitulo, Monica Castellucci, Daniela Cecconi, Jessica Brandi, Nikolaos Vareltzakis, Fabiana Mainieri, Antonella Calore, Gabriele Angelini, Bruno Bonetti, Gabriela Constantin   +21 more
doaj   +1 more source

Granzyme K: An Important Mediator of Cutaneous Inflammation and Re‐epithelialization

The FASEB Journal, 2019
Background Granzyme K (GzmK) is a serine protease traditionally thought as having a role in immune cell‐mediated killing. However, recent evidence has challenged this paradigm. We now believe GzmK is a mediator of inflammation. GzmK is elevated in plasma from patients with a variety of pro‐inflammatory disorders,
Katlyn Richardson, Chris Turner, Matthew Zeglinski, Hongyan Zhao, Yue Shen, David Granville   +5 more
openaire   +1 more source

Granzyme K+CD8+ T cells interact with fibroblasts to promote neutrophilic inflammation in nasal polyps

Nature Communications
Sophisticated interactions between stromal and immune cells play crucial roles in various biological and pathological processes. In chronic rhinosinusitis with nasal polyps (CRSwNP), the upper airway inflammation in many patients is driven by TH2, ILC2 ...
Cui-Lian Guo, Chong-Shu Wang, Zhi-Chao Wang, Fei-Fan Liu, Lin Liu, Yang Yang, Xia Li, Bei Guo, Ruo-Yu Lu, Bo Liao, Jin-Xin Liu, Hai Wang, Jia Song, Yin Yao, Li-Ping Zhu, Di Yu, Zheng Liu   +16 more
doaj   +1 more source

Granzymes in health and diseases: the good, the bad and the ugly

Frontiers in Immunology
Granzymes are a family of serine proteases, composed of five human members: GA, B, H, M and K. They were first discovered in the 1980s within cytotoxic granules released during NK cell- and T cell-mediated killing.
Lavinia Cigalotto, Lavinia Cigalotto, Denis Martinvalet, Denis Martinvalet   +3 more
doaj   +1 more source

Targeting IL-1β as an immunopreventive and therapeutic modality for K-ras–mutant lung cancer

JCI Insight, 2022
K-ras–mutant lung adenocarcinoma (KM-LUAD) is associated with abysmal prognosis and is tightly linked to tumor-promoting inflammation. A human mAb, canakinumab, targeting the proinflammatory cytokine IL-1β, significantly decreased the risk of lung cancer
Bo Yuan, Michael J. Clowers, Walter V. Velasco, Stephen Peng, Qian Peng, Yewen Shi, Marco Ramos-Castaneda, Melody Zarghooni, Shuanying Yang, Rachel L. Babcock, Seon Hee Chang, John V. Heymach, Jianjun Zhang, Edwin J. Ostrin, Stephanie S. Watowich, Humam Kadara, Seyed Javad Moghaddam   +16 more
doaj   +1 more source

Extracellular granzyme K enhances PD-L1 transcription and stability via F2RL1 activation to facilitate tumor immune evasion in lung adenocarcinoma

Journal for ImmunoTherapy of Cancer
Background Granzyme K (GZMK) is a serine protease known for its perforin-dependent cytotoxicity. However, the non-cytotoxic role of GZMK in lung adenocarcinoma (LUAD) remains largely elusive.Methods Multiomics datasets were integrated to investigate the ...
Bin Li, Zheng Li, Ning Yang, Ye Zhao, Ke-Rong Zhai, Hai-Ming Feng, Tie-Niu Song, Yu-Qi Meng, Hui-Rong Huang, Bai-Qiang Cui, Zhi-Peng Su   +10 more
doaj   +1 more source