Results 21 to 30 of about 149 (110)

RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation.

PLoS Pathogens, 2017
Chikungunya virus (CHIKV) is an arthritogenic alphavirus causing epidemics of acute and chronic arthritic disease. Herein we describe a comprehensive RNA-Seq analysis of feet and lymph nodes at peak viraemia (day 2 post infection), acute arthritis (day 7)
Jane A C Wilson, Natalie A Prow, Wayne A Schroder, Jonathan J Ellis, Helen E Cumming, Linden J Gearing, Yee Suan Poo, Adam Taylor, Paul J Hertzog, Francesca Di Giallonardo, Linda Hueston, Roger Le Grand, Bing Tang, Thuy T Le, Joy Gardner, Suresh Mahalingam, Pierre Roques, Phillip I Bird, Andreas Suhrbier   +18 more
doaj   +1 more source

CD56^brightCD16^– natural killer cells as an important regulatory mechanism in chronic graft-versus-host disease

Haematologica, 2022
Chronic graft-versus-host disease (cGvHD) is a major cause of morbidity after hematopoietic stem cell transplantation (HSCT). In large patient populations, we have shown a CD56bright natural killer (NK) population to strongly associate with a lack of ...
Madeline Lauener, Shima AzadPour, Sayeh Abdossamadi, Vaishnavi Parthasarathy, Bernard Ng, Elena Ostroumov, Geoffrey D.E. Cuvelier, Megan K. Levings, Katherine N. MacDonald, Amina Kariminia, Kirk R. Schultz   +10 more
doaj   +1 more source

Identification of a Glycosyltransferase Signature for Predicting Prognosis and Immune Microenvironment in Neuroblastoma

Frontiers in Cell and Developmental Biology, 2022
Neuroblastoma (NB) is one of the most common solid tumors in children. Glycosyltransferases (GTs) play a crucial role in tumor development and immune escape and have been used as prognostic biomarkers in various tumors.
Yongliang Sha, Yongliang Sha, Yongliang Sha, Yongliang Sha, Lei Han, Lei Han, Lei Han, Lei Han, Bei Sun, Bei Sun, Bei Sun, Bei Sun, Qiang Zhao, Qiang Zhao, Qiang Zhao, Qiang Zhao   +15 more
doaj   +1 more source

Enzymatic bioconversion of ginseng powder increases the content of minor ginsenosides and potentiates immunostimulatory activity

Journal of Ginseng Research, 2022
Background: Ginsenosides are biologically active components of ginseng and have various functions. In this study, we investigated the immunomodulatory activity of a ginseng product generated from ginseng powder (GP) via enzymatic bioconversion.
Jisang Park, Ju Kim, Eun-Sil Ko, Jong Hoon Jeong, Cheol-Oh Park, Jeong Hun Seo, Yong-Suk Jang   +6 more
doaj   +1 more source

090. Effect of Turmeric Extract (Curcuma longa) on Granzyme Exoration and Tumour Mass Diameter Studi Pada Model Mencit Adenocarcinoma Mammae dengan Pemberian Kemoterapi Adriamycin Cyclophosphamide

JBN (Jurnal Bedah Nasional)
Background: Breast cancer accounts for 11.6% of new cancer cases and 6.6% of cancer deaths. Treatment varies based on cancer type and stage, with Complementary Alternative Medicine (CAM) used as adjunct therapy.
Bachtiar Eko Nugroho, Selamat Budijitno
doaj   +1 more source

Comprehensive Analysis of Granzymes and Perforin Family Genes in Multiple Cancers

Biomedicines
Background/Objectives: Cancer remains a significant global health concern, with immunotherapies emerging as promising treatments. This study explored the role of perforin-1 (PRF1) and granzymes A, B and K (GZMA, GZMB and GZMK) in cancer biology, focusing
Manvita Mareboina, Katrina Bakhl, Stephanie Agioti, Nelson S. Yee, Ilias Georgakopoulos-Soares, Apostolos Zaravinos   +5 more
doaj   +1 more source

Granzymes A and K differentially potentiate LPS-induced cytokine response

Cell Death Discovery, 2016
AbstractGranzymes are serine proteases that, upon release from cytotoxic cells, induce apoptosis in tumor cells and virally infected cells. In addition, a role of granzymes in inflammation is emerging. Recently, we have demonstrated that extracellular granzyme K (GrK) potentiates lipopolysaccharide (LPS)-induced cytokine response from monocytes.
Wensink, Annette C, Kok, Helena M, Meeldijk, Jan, Fermie, Job, Froelich, Christopher J, Hack, C Erik, Bovenschen, Niels   +6 more
openaire   +4 more sources

Immune cell single-cell RNA sequencing analyses link an age-associated T cell subset to symptomatic benign prostatic hyperplasia

Frontiers in Immunology
IntroductionBenign prostatic hyperplasia (BPH) is among the most common age-associated diseases in men. Prostatic immune cell infiltration is frequently observed with aging coincident with BPH; however, the contribution of age-related changes in immune ...
Meaghan M. Broman, Nadia A. Lanman, Nadia A. Lanman, Renee E. Vickman, Renee E. Vickman, Gregory M. Cresswell, Harish Kothandaraman, Andree Kolliegbo, Juan Sebastian Paez Paez, Juan Sebastian Paez Paez, Alexander P. Glaser, Alexander P. Glaser, Brian T. Helfand, Brian T. Helfand, Gervaise Henry, Douglas W. Strand, Omar E. Franco, Simon W. Hayward, Simon W. Hayward, Timothy L. Ratliff, Timothy L. Ratliff   +20 more
doaj   +1 more source

Mucosal IL-4R antagonist HIV vaccination with SOSIP-gp140 booster can induce high-quality cytotoxic CD4+/CD8+ T cells and humoral responses in macaques

Scientific Reports, 2020
Inducing humoral, cellular and mucosal immunity is likely to improve the effectiveness of HIV-1 vaccine strategies. Here, we tested a vaccine regimen in pigtail macaques using an intranasal (i.n.) recombinant Fowl Pox Virus (FPV)-gag pol env-IL-4R ...
Z. Li, M. Khanna, S. L. Grimley, P. Ellenberg, C. A. Gonelli, Wen Shi Lee, T. H. Amarasena, A. D. Kelleher, D. F. J. Purcell, S. J. Kent, C. Ranasinghe   +10 more
doaj   +1 more source

Detection of soluble human granzyme K in vitro and in vivo

European Journal of Immunology, 2005
AbstractGranzymes are serine proteases released from the granules of cytotoxic lymphocytes during the induction of apoptosis. To evaluate the physiologic role of human granzyme K (GzmK), we developed a sensitive ELISA which was shown to specifically detect human GzmK in its active as well as its inactive conformation.
Bade, Britta, Lohrmann, Jens, ten Brinke, Anja, Wolbink, Angela M., Wolbink, Gert-Jan, ten Berge, Ineke J. M., Virchow, J. Christian, Luttmann, Werner, Hack, C. Erik   +8 more
openaire   +2 more sources