Results 11 to 20 of about 149 (110)
Granzyme K Activates Protease-Activated Receptor-1 [PDF]
PLoS ONE, 2011 Granzyme K (GrK) is a trypsin-like serine protease that is elevated in patients with sepsis and acute lung inflammation. While GrK was originally believed to function exclusively as a pro-apoptotic protease, recent studies now suggest that GrK may possess other non-cytotoxic functions. In the context of acute lung inflammation, we hypothesized that GrK
Dawn M Cooper +4 more
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Effect of Granzyme K, FasL and Interferon-γ Expression in Placentas with Preeclampsia [PDF]
BiomedicinesThis study aimed to investigate the cytotoxic activity of decidual lymphocytes and the mRNA/protein expression of cytotoxic proteins in various cell types in the context of preeclampsia (PE) compared to those of healthy pregnancies. We analyzed fresh decidua basalis tissue and tissue embedded in paraffin (FFPE) from PE pregnancies (n = 15) and compared
Martina Vukoja +6 more
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Pro-inflammatory granzyme K contributes extracellularly to disease
Frontiers in ImmunologyGranzyme K (GzmK) is an immune-secreted serine protease typically expressed at low levels but elevated in response to tissue injury and disease. Known as an orphan granzyme due to limited scientific investigation, this tryptase is being redefined as having important roles in inflammation and disease pathogenesis.
Christopher T. Turner
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Frontiers in Aging, 2023 Granzymes are a family of serine-proteases that act as critical mediators in the cytolytic and immunomodulatory activities of immune cells such as CD8+ T-cells and natural killer (NK) cells.
Chris P. Verschoor +8 more
doaj +1 more source
PLoS ONE, 2022 Granzyme K (GzmK) is a tryptic member of the granzyme family of chymotrypsin-like serine proteases produced by cells of the immune system. Previous studies have indicated that GzmK activates protease-activated receptor 1 (PAR1) enhancing activation of ...
Dion Kaiserman +11 more
doaj +2 more sources
Frontiers in Oncology, 2021 Angiogenesis is crucial for normal development and homeostasis, but also plays a role in many diseases including cardiovascular diseases, autoimmune diseases, and cancer.
Shuang Li +12 more
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Distinct Effector Programs of Brain-Homing CD8+ T Cells in Multiple Sclerosis
Cells, 2022 The effector programs of CD8+ memory T cells are influenced by the transcription factors RUNX3, EOMES and T-bet. How these factors define brain-homing CD8+ memory T cells in multiple sclerosis (MS) remains unknown. To address this, we analyzed blood, CSF
Steven C. Koetzier +10 more
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Expression of intra- and extracellular granzymes in patients with typhoid fever.
PLoS Neglected Tropical Diseases, 2017 BackgroundTyphoid fever, caused by the intracellular pathogen Salmonella (S.) enterica serovar Typhi, remains a major cause of morbidity and mortality worldwide.
Hanna K de Jong +8 more
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Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution. [PDF]
PLoS ONE, 2015 Serine proteases are among the most abundant granule constituents of several hematopoietic cell lineages including mast cells, neutrophils, cytotoxic T cells and NK cells. These proteases are stored in their active form in the cytoplasmic granules and in
Srinivas Akula +3 more
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Frontiers in Immunology, 2018 Natural killer (NK) cells eliminate infected and tumorigenic cells through delivery of granzymes via perforin pores or by activation of caspases via death receptors.
Clarissa Liesche +7 more
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