Results 21 to 30 of about 52,710 (257)

Decreased Expression of Cytotoxic Proteins in Decidual CD8⁺ T Cells in Preeclampsia

Biology, 2021
In our study, we aimed to establish expression of cytotoxic CD8+ T cells in the decidua basalis and the maternal peripheral blood (mPBL) of severe and mild preeclampsia (PE) and compare to healthy pregnancies.
Violeta Soljic, Maja Barbaric, Martina Vukoja, Marina Curlin, Martina Orlovic Vlaho, Edita Cerni Obrdalj, Lidija Lasic Arapovic, Daniela Bevanda Glibo, Katarina Vukojevic   +8 more
doaj   +1 more source

Granzyme B Attenuates Bacterial Virulence by Targeting Secreted Factors

iScience, 2020
Summary: Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to ...
Diego López León, Patricia Matthey, Isabelle Fellay, Marianne Blanchard, Denis Martinvalet, Pierre-Yves Mantel, Luis Filgueira, Michael Walch   +7 more
doaj   +1 more source

Targeted Cell-to-Cell Delivery of Protein Payloads via the Granzyme-Perforin Pathway

Molecular Therapy: Methods & Clinical Development, 2017
There is great potential for engineering cellular therapeutics by repurposing biological systems. Here, we report utilization of the granzyme-perforin pathway of cytotoxic lymphocytes as a cell-to-cell protein delivery module. We designed and constructed
Daniel J. Woodsworth, Lisa Dreolini, Libin Abraham, Robert A. Holt   +3 more
doaj   +1 more source

Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution. [PDF]

PLoS ONE, 2016
Granzyme B is one of the key effector molecules in our defense against viruses and intracellular bacteria. This serine protease together with the pore forming protein perforin, induces caspase or Bid-dependent apoptosis in target cells.
Zhirong Fu, Michael Thorpe, Srinivas Akula, Lars Hellman   +3 more
doaj   +1 more source

Granzyme B cleavage of autoantigens in autoimmunity [PDF]

Cell Death & Differentiation, 2010
The systemic autoimmune diseases are a complex group of disorders characterized by elaboration of high titer autoantibodies and immune-mediated damage of tissues. Two striking features of autoimmune rheumatic diseases are their self-sustaining nature and capacity for autoamplification, exemplified by disease flares.
E, Darrah, A, Rosen
openaire   +2 more sources

Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway

BMC Immunology, 2009
Background Regulatory T cells (Tregs) can employ a cell contact- and granzyme B-dependent mechanism to mediate suppression of bystander T and B cells.
Kelley Todd W, Efimova Olga V
doaj   +1 more source

Granzyme B inhibition reduces disease severity in autoimmune blistering diseases

Nature Communications, 2021
Pemphigoid diseases involve autoimmune mediated blistering and immunopathology of the upper dermis. Here, the authors implicate granzyme B in the immunopathology in multiple in vivo models of pemphigoid diseases and utilise a topical granzyme B inhibitor
Sho Hiroyasu, Matthew R. Zeglinski, Hongyan Zhao, Megan A. Pawluk, Christopher T. Turner, Anika Kasprick, Chiharu Tateishi, Wataru Nishie, Angela Burleigh, Peter A. Lennox, Nancy Van Laeken, Nick J. Carr, Frank Petersen, Richard I. Crawford, Hiroshi Shimizu, Daisuke Tsuruta, Ralf J. Ludwig, David J. Granville   +17 more
doaj   +1 more source

Discordant Regulation of Granzyme H and Granzyme B Expression in Human Lymphocytes [PDF]

Journal of Biological Chemistry, 2004
We analyzed the expression of granzyme H in human blood leukocytes, using a novel monoclonal antibody raised against recombinant granzyme H. 33-kDa granzyme H was easily detected in unfractionated peripheral blood mononuclear cells, due to its high constitutive expression in CD3(-)CD56(+) natural killer (NK) cells, whereas granzyme B was less abundant.
Karin A, Sedelies, Thomas J, Sayers, Kirsten M, Edwards, Weisan, Chen, Daniel G, Pellicci, Dale I, Godfrey, Joseph A, Trapani   +6 more
openaire   +2 more sources

Expression of intra- and extracellular granzymes in patients with typhoid fever.

PLoS Neglected Tropical Diseases, 2017
BackgroundTyphoid fever, caused by the intracellular pathogen Salmonella (S.) enterica serovar Typhi, remains a major cause of morbidity and mortality worldwide.
Hanna K de Jong, Maria Isabel Garcia-Laorden, Arie J Hoogendijk, Christopher M Parry, Rapeephan R Maude, Arjen M Dondorp, Mohammed Abul Faiz, Tom van der Poll, Willem Joost Wiersinga   +8 more
doaj   +1 more source

A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

Nature Communications, 2022
Granzyme B is found in activated T cells and can be used as a marker of T cell activation. Here, the authors generate a fluorescent probe that can detect Granzyme B levels in tumours, and has the potential to be used as a biomarker of response to ...
Jamie I. Scott, Lorena Mendive-Tapia, Doireann Gordon, Nicole D. Barth, Emily J. Thompson, Zhiming Cheng, David Taggart, Takanori Kitamura, Alberto Bravo-Blas, Edward W. Roberts, Jordi Juarez-Jimenez, Julien Michel, Berber Piet, I. Jolanda de Vries, Martijn Verdoes, John Dawson, Neil O. Carragher, Richard A. O’ Connor, Ahsan R. Akram, Margaret Frame, Alan Serrels, Marc Vendrell   +21 more
doaj   +1 more source