Results 11 to 20 of about 52,710 (257)

Lower Circulating Cytotoxic T-Cell Frequency and Higher Intragraft Granzyme-B Expression Are Associated with Inflammatory Interstitial Fibrosis and Tubular Atrophy in Renal Allograft Recipients

Medicina, 2023
Background and Objectives: Inflammatory interstitial fibrosis and tubular atrophy (i-IFTA) is an inflammation in the area of tubular atrophy and fibrosis.
Brijesh Yadav, Narayan Prasad, Vinita Agrawal, Vikas Agarwal, Manoj Jain   +4 more
doaj   +1 more source

NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection

Cell Reports, 2023
Summary: Genital herpes is characterized by recurrent episodes of epithelial blistering. The mechanisms causing this pathology are ill defined. Using a mouse model of vaginal herpes simplex virus 2 (HSV-2) infection, we show that interleukin-18 (IL-18 ...
Ying Shiang Lim, Aisha G. Lee, Xiaoping Jiang, Jason M. Scott, Adjoa Cofie, Sandeep Kumar, Dania Kennedy, David J. Granville, Haina Shin   +8 more
doaj   +1 more source

Comparative immune responses to Mycobacterium tuberculosis in people with latent infection or sterilizing protection

iScience, 2023
Summary: There is great need for vaccines against tuberculosis (TB) more efficacious than the licensed BCG. Our goal was to identify new vaccine benchmarks by identifying immune responses that distinguish individuals able to eradicate the infection (TB ...
Emilie Jalbert, Cuining Liu, Vidya Mave, Nancy Lang, Anju Kagal, Chhaya Valvi, Mandar Paradkar, Nikhil Gupte, Rahul Lokhande, Renu Bharadwaj, Vandana Kulkarni, Amita Gupta, Adriana Weinberg   +12 more
doaj   +1 more source

Perforin and granzyme B have separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout mice. [PDF]

PLoS ONE, 2013
The granzyme B/perforincytotoxic pathway is a well established mechanism of initiating target cell apoptosis. Previous studies have suggested a role for the granzyme B/perforin cytotoxic pathway in vulnerable atherosclerotic plaque formation.
Paul R Hiebert, Wendy A Boivin, Hongyan Zhao, Bruce M McManus, David J Granville   +4 more
doaj   +1 more source

Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes

Frontiers in Immunology, 2022
Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4+ Th17 cells are considered pathogenic in MS and are harmful to OLs.
Hélène Jamann, Hélène Jamann, Qiao-Ling Cui, Haritha L. Desu, Haritha L. Desu, Florian Pernin, Olivier Tastet, Alexandre Halaweh, Alexandre Halaweh, Negar Farzam-kia, Negar Farzam-kia, Victoria Hannah Mamane, Victoria Hannah Mamane, Oumarou Ouédraogo, Oumarou Ouédraogo, Aurélie Cleret-Buhot, Audrey Daigneault, Renaud Balthazard, Renaud Balthazard, Wendy Klement, Wendy Klement, Florent Lemaître, Florent Lemaître, Nathalie Arbour, Nathalie Arbour, Jack Antel, Jo Anne Stratton, Catherine Larochelle, Catherine Larochelle   +28 more
doaj   +1 more source

Elevated serum granzyme B levels are associated with disease activity and joint damage in patients with rheumatoid arthritis

Journal of International Medical Research, 2020
Objectives Little is known about the roles of granzyme B in rheumatoid arthritis (RA). We aimed to evaluate the serum level of granzyme B in patients with RA and determine relationships with clinical features and joint destruction of RA.
Junjie Qiao, Meng Zhou, Zheng Li, Jie Ren, Guanghan Gao, Jumei Zhen, Guanglei Cao, Lixiang Ding   +7 more
doaj   +1 more source

Study of serum Granzyme B in heavy cigarette smokers with and without chronic obstructive pulmonary disease

Egyptian Journal of Chest Disease and Tuberculosis, 2014
Background: Inflammation of the airways is present in COPD with increased number of inflammatory cells including killer cells that lyse their target cells by two mechanisms; membranolysis in which secreted molecules such as granzymes form pores in the ...
Ahmed A. Yousef, Mahmoud M. Alsalahy, Mohammad A. Almahdy, Tarek S. Essawy, Khalid M. Belal   +4 more
doaj   +1 more source

NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells

Frontiers in Immunology, 2021
Natural Killer (NK) cells are cytotoxic lymphocytes critical to the innate immune system. We found that germline deficiency of NF-κB c-Rel results in a marked decrease in cytotoxic function of NK cells, both in vitro and in vivo, with no significant ...
Yorleny Vicioso, Derek P. Wong, Nand K. Roy, Nayanika Das, Keman Zhang, Parameswaran Ramakrishnan, Parameswaran Ramakrishnan, Reshmi Parameswaran, Reshmi Parameswaran   +8 more
doaj   +1 more source

Dual roles of granzyme B [PDF]

Scandinavian Journal of Immunology, 2021
AbstractGranzyme B (GZMB) was first identified as a factor that could eliminate cells such as tumour cells and bacteria/virus‐infected cells. However, comprehensive studies conducted on GZMB have gradually revealed the negative extracellular functions of GZMB; for example, it is an aetiology and a factor responsible for the aggravation of several ...
Huiling Wang, Yong Huang, Jian He, Liping Zhong, Yongxiang Zhao   +4 more
openaire   +1 more source

Study of effect of inhaled versus oral corticosteroids on sputum granzyme B in patients with moderate persistent bronchial asthma

Egyptian Journal of Chest Disease and Tuberculosis, 2015
Background: Asthma is a major public health problem with a high economic burden. It involves several inflammatory cells and multiple mediators. Granzyme B is an inflammatory mediator expressed and secreted by both immune and non immune cells. Recently it
Walaa K. Shoeib, Mahmoud M. Alsalahy, Mohammad A. Almahdy, Tarek S. Essawy, Khalid M. Belal   +4 more
doaj   +1 more source