Results 31 to 40 of about 51,558 (279)
Perforin competent CD8 T cells are sufficient to cause immune-mediated blood-brain barrier disruption. [PDF]
PLoS ONE, 2014 Numerous neurological disorders are characterized by central nervous system (CNS) vascular permeability. However, the underlying contribution of inflammatory-derived factors leading to pathology associated with blood-brain barrier (BBB) disruption ...
Holly L Johnson +6 more
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Frontiers in Immunology, 2021 Malaria remains one of the most serious health problems in developing countries. The causative agent of malaria, Plasmodium spp., have a complex life cycle involving multiple developmental stages as well as different morphological, biochemical and ...
Maria Andrea Hernández-Castañeda +9 more
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Perforin and hematological cancer [PDF]
Revista Brasileira de Hematologia e Hemoterapia, 2011 Perforin (PRF) is a soluble cytotoxic pore-forming glycoprotein that is a crucial component of the cocktail of cytotoxic granules harbored by cytotoxic T lymphocytes (CTL) and natural killer cells (NK), collectively known as cytotoxic lymphocytes (CLs).
openaire +5 more sources
The transcriptional control of the perforin locus [PDF]
Immunological Reviews, 2010 Summary: Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) use cytotoxic granules containing perforin and granzymes to lyse infected or malignant host cells, thereby providing immunity to intracellular microbes and tumors. Perforin is essential for cytotoxic granule‐mediated killing.
Matthew E, Pipkin +2 more
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Vδ2 T-Cells Kill ZIKV-Infected Cells by NKG2D-Mediated Cytotoxicity
Microorganisms, 2019 An expansion of effector/activated Vδ2 T-cells was recently described in acute Zika virus (ZIKV)-infected patients, but their role in the protective immune response was not clarified.
Eleonora Cimini +12 more
doaj +1 more source
The State of Peripheral Blood Natural Killer Cells and Cytotoxicity in Women with Recurrent Pregnancy Loss and Unexplained Infertility [PDF]
International Journal of Fertility and Sterility, 2019 Background The prognostic value of peripheral natural killer (pNK) cells, as a screening test in women with recur- rent pregnancy loss (RPL) and unexplained infertility, is still a matter for discussion.
Azam Azargoon +4 more
doaj +1 more source
Frontiers in Immunology, 2021 It remains undefined whether a subset of CD4+ T cells can function as fast-acting cells to control Mycobacterium tuberculosis (Mtb) infection. Here we show that the primary CD4+CD161+ T-cell subset, not CD4+CD161-, in unexposed healthy humans fast acted ...
Rui Yang +12 more
doaj +1 more source
The FASEB Journal, 2019 The liver is a central immunologic organ with a high density of myeloid and lymphoid immune cells that play important roles in the development and progression of nonalcoholic steatohepatitis (NASH).
Tianqi Wang +11 more
semanticscholar +1 more source
PHENOTYPIC AND FUNCTIONAL CHARACTERISTICS OF MICROVESICLES PRODUCED BY NATURAL KILLER CELLS
Медицинская иммунология, 2019 Natural killer (NK) cells are of special interest among a multitude of microvesicle (MV) source cells. NK cells are a lymphocyte subpopulation performing contact cytolysis of virus-infected cells and tumor cells.
D. I. Sokolov +11 more
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Cytotoxic Efficiency of Human CD8+ T Cell Memory Subtypes
Frontiers in Immunology, 2022 Immunological memory is important to protect humans against recurring diseases. Memory CD8+ T cells are required for quick expansion into effector cells but also provide immediate cytotoxicity against their targets. Whereas many functions of the two main
Arne Knörck +6 more
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