Results 41 to 50 of about 51,558 (279)

Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin

Nature Communications, 2017
The connection between innate and adaptive immunity is best exemplified by antigen presentation. Although antigen-presenting cells (APCs) are required for antigen receptor-mediated T-cell activation, how T-cells feedback to APCs to sustain an antigen ...
Yikun Yao, Siyuan Chen, Mengtao Cao, Xing Fan, T. Yang, Yin Huang, Xinyang Song, Yongqin Li, L. Ye, N. Shen, Yufang Shi, Xiaoxia Li, Feng Wang, Youcun Qian   +13 more
semanticscholar   +1 more source

Detection of Perforin in suspension of leukemia lymphocyte culture

مجلة مركز بحوث التقنيات الاحيائية, 2014
This work aimed to study the concentrations and hemolytic assay of perforin in serum and culture suspension of lymphocyte for acute lymphocyte leukemia ALL; chronic lymphocyte leukemia CLL, and control. To achieve this goal, blood samples were collected
Najwa Sh. Ahmed, Amal G.S. Fayyad, Wan Mohter Yusoff, Subhi Jawad Hamza, Abdul Hussen Al-Faisal, Adeeb A. AL-Shami   +5 more
doaj   +1 more source

The Expanding Arsenal of Cytotoxic T Cells

Frontiers in Immunology, 2022
Cytotoxic T cells (CTLs) are the main cellular mediators of the adaptive immune defenses against intracellular pathogens and malignant cells. Upon recognition of specific antigen on their cellular target, CTLs assemble an immunological synapse where they
Chiara Cassioli, Cosima T. Baldari
doaj   +1 more source

Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites

Nature Medicine, 2016
Protozoan infections are a serious global health problem. Natural killer (NK) cells and cytolytic T lymphocytes (CTLs) eliminate pathogen-infected cells by releasing cytolytic granule contents—granzyme (Gzm) proteases and the pore-forming perforin (PFN ...
Farokh Dotiwala, S. Mulik, Rafael B. Polidoro, James A Ansara, B. Burleigh, M. Walch, R. Gazzinelli, J. Lieberman   +7 more
semanticscholar   +1 more source

Perforin deficiency and susceptibility to cancer [PDF]

Cell Death & Differentiation, 2010
Cytotoxic lymphocytes (CLs) are the killer cells that destroy intracellular pathogen-infected and transformed cells, predominantly through the cytotoxic granule-mediated death pathway. Soluble cytotoxic granule components, including pore-forming perforin and pro-apoptotic serine proteases, granzymes, synergize to induce unscheduled apoptosis of the ...
A J, Brennan, J, Chia, J A, Trapani, I, Voskoboinik   +3 more
openaire   +2 more sources

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

The CML experience to elucidate the role of innate T-cells as effectors in the control of residual cancer cells and as potential targets for cancer therapy

Frontiers in Immunology
Considering the general view that unconventional immune effectors play a major role in antitumor immunity, we recently postulated that the distinct new innate CD8 T-cell pool (co-expressing the transcription factor Eomesodermin and innate markers such as
Amandine Decroos, Amandine Decroos, Sarah Meddour, Sarah Meddour, Marine Demoy, Marine Demoy, Nathalie Piccirilli, Nathalie Piccirilli, Philippe Rousselot, Philippe Rousselot, Philippe Rousselot, Franck E. Nicolini, Franck E. Nicolini, Stéphanie Ragot, Jean-Marc Gombert, Jean-Marc Gombert, André Herbelin, Alice Barbarin, Emilie Cayssials, Emilie Cayssials, Emilie Cayssials, Emilie Cayssials   +21 more
doaj   +1 more source

Decreased Expression of Cytotoxic Proteins in Decidual CD8⁺ T Cells in Preeclampsia

Biology, 2021
In our study, we aimed to establish expression of cytotoxic CD8+ T cells in the decidua basalis and the maternal peripheral blood (mPBL) of severe and mild preeclampsia (PE) and compare to healthy pregnancies.
Violeta Soljic, Maja Barbaric, Martina Vukoja, Marina Curlin, Martina Orlovic Vlaho, Edita Cerni Obrdalj, Lidija Lasic Arapovic, Daniela Bevanda Glibo, Katarina Vukojevic   +8 more
doaj   +1 more source

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis

Nature Communications, 2018
CD8 T cells protect the liver against viral infection, but can also cause severe liver damage that may even lead to organ failure. Given the lack of mechanistic insights and specific treatment options in patients with acute fulminant hepatitis, we ...
M. Welz, S. Eickhoff, Zeinab Abdullah, J. Trebicka, Kate H. Gartlan, J. Spicer, A. Demetris, Hedieh Akhlaghi, Martina Anton, K. Manske, D. Zehn, B. Nieswandt, C. Kurts, J. Trapani, P. Knolle, D. Wohlleber, W. Kastenmüller, W. Kastenmüller   +17 more
semanticscholar   +1 more source

Administering Blinatumomab via Continuous Intravenous Infusion in Pediatric Patients—A Single‐Institution Retrospective Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab, a CD19xCD3 bispecific T‐cell engager, has become standard therapy for children with de novo B‐cell acute lymphoblastic leukemia (B‐ALL). This retrospective review describes the experience of blinatumomab administration in pediatric patients.
Julia M. Hurley, Ryleigh Krueger, Kellie Joyce, James Stanley, Mary Waskerwitz‐Freyer, Marielle Klunder, David J. Hoogstra   +6 more
wiley   +1 more source