Results 261 to 270 of about 78,129 (305)
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Human neutrophils lack granzyme A, granzyme B, and perforin
Blood, 2004Wagner et al[1][1] and Hochegger et al[2][2] reported that human polymorphonuclear neutrophils (PMNs) express granzyme A (GzmA), granzyme B (GzmB), and perforin (PFN), postulating a role for these granule proteins in PMN-mediated antibody-dependent cellular cytotoxicity.
Sunil S. Metkar, Christopher J. Froelich
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1994
Publisher Summary This chapter highlights purification and assay methods for granzyme B. The highest levels of granzyme B are found in the granules of cytotoxic T lymphocytes (CTLs). Lower levels of granzyme B are found in helper T cells and in thymocytes.
Manuel C. Peitsch, Juerg Tschopp
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Publisher Summary This chapter highlights purification and assay methods for granzyme B. The highest levels of granzyme B are found in the granules of cytotoxic T lymphocytes (CTLs). Lower levels of granzyme B are found in helper T cells and in thymocytes.
Manuel C. Peitsch, Juerg Tschopp
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Entry and Trafficking of Granzyme B in Target Cells During Granzyme B-Perforin–Mediated Apoptosis
Blood, 1998AbstractIn the widely accepted model of granule-mediated killing by cytotoxic lymphocytes, granzyme B entry into the target cell is facilitated by the pore forming molecule, perforin. Using indirect immunofluorescence and also direct visualization of fluorescein isothiocyanate (FITC)-conjugated granzyme B, we demonstrate internalization in the absence ...
M J, Pinkoski +7 more
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Granzyme B in skin inflammation and disease
Matrix Biology, 2019Granzyme B (GzmB) is a serine protease emerging as an important mediator of skin injury, inflammation and repair. Found at low levels in healthy skin, GzmB is dramatically elevated in chronic disease and inflammatory skin disorders, including diabetic ulcers, hypertrophic scarring, autoimmune skin disorders, cutaneous leishmaniasis and aging skin ...
Christopher T, Turner +2 more
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1996
In the last several years the major mechanisms by which both cytotoxic T lymphocytes (CTL) and natural killer (NK) cells mediate cell death and apoptosis have been identified. Cytotoxic lymphocytes of both types induce apoptosis through granule-or Fas-dependent pathway 1-4and perhaps TNF-α5.
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In the last several years the major mechanisms by which both cytotoxic T lymphocytes (CTL) and natural killer (NK) cells mediate cell death and apoptosis have been identified. Cytotoxic lymphocytes of both types induce apoptosis through granule-or Fas-dependent pathway 1-4and perhaps TNF-α5.
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Identification and characterization of equine granzyme B
Veterinary Immunology and Immunopathology, 2007In the present study we describe the isolation and characterization of putative equine granzyme B for which we propose the designation 'eqGrzmB'. Sequence analysis revealed characteristic features of a GrzmB protease such as the presence of a signal (leader-) peptide and an activation di-peptide.
Konrad, Piuko +2 more
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Purification and Use of Granzyme B
2000Granzyme B (GrB) is the primary molecular mediator of apoptosis by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. It is a unique mammalian aspartic acid-cleaving serine protease. On T cell receptor activation, GrB is released from the CTL cytoplasmic granules by exocytosis, enters the target cells and, in the presence of the granule pore-
L, Shi +3 more
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Granzyme B in injury, inflammation, and repair
Trends in Molecular Medicine, 2012Fragile skin and susceptibility to skin tearing are major problems among the elderly and can be complicated further by impaired wound healing. Non-healing wounds fail to progress through the normal stages of healing and enter a state of chronic inflammation featuring increased proteolytic activity. Increased expression of the serine protease granzyme B
Paul R, Hiebert, David J, Granville
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Granzyme B producing B-cells in renal transplant patients
Clinical Immunology, 2017A separate subset of Granzyme B (GrB) producing B-cells regulating T-cell mediated immunity has been identified. In the present study, we investigated the role of GrB+ B-cells in renal transplant patients (RTX).12 healthy controls (HC) and 26 RTX patients were enrolled. In addition, 19 healthy volunteers treated with cyclosporine A (CsA) were enrolled.
Jiqiao Zhu +13 more
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H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells
Trends in Immunology, 2007It is commonly held that the various granzymes (lethal proteases produced by cytotoxic lymphocytes) utilize their different substrate preferences to bring about various forms of target cell death. Although a considerable body of evidence supports this view, it has now become clear that human granzyme H could have evolved a proteolytic specificity that ...
Nigel J, Waterhouse, Joseph A, Trapani
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