Results 271 to 280 of about 78,129 (305)
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Delivery and therapeutic potential of human granzyme B
Immunological Reviews, 2010Summary: Granzyme B (GzmB) is used by cytotoxic lymphocytes as a molecular weapon for the defense against virus‐infected and malignantly transformed host cells. It belongs to a family of small serine proteases that are stored in secretory vesicles of killer cells.
Kurschus, F., Jenne, D.
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INCREASED GRANZYME B mRNA AFTER ALLOINCOMPATIBLE MYOBLAST TRANSPLANTATION
Transplantation, 1995Normal C57BL/10SnJ myoblasts were transplanted into the tibialis anterior of C57BL/10SnJ, C57BL/ScSn mdx, or BALB/c mice. These transplantations allowed us to investigate the immune response not only against MHC but also against dystrophin introduced in the dystrophic muscles by such transplantations.
B, Guérette +6 more
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Cytotoxic activity of the lymphocyte toxin granzyme B
Microbes and Infection, 2004Cytotoxic lymphocytes protect their host from viral infection and cellular transformation by delivering a range of toxins stored within intracellular granules. One of the most potent of these toxins is the serine protease granzyme B. This review will discuss mechanisms used by granzyme B to enter target cells and the ways in which it synergizes with ...
Michelle E, Wowk, Joseph A, Trapani
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Respirology, 2013
AbstractBackground and objectiveThe non‐eosinophilic phenotype of asthma (NEA) is associated with chronic airway inflammation and airway neutrophilia. An accumulation of apoptotic airway epithelial cells, if not efficiently cleared by efferocytosis, can undergo secondary necrosis, with the potential for inflammation of surrounding tissues.
Simpson, Jodie L. +7 more
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AbstractBackground and objectiveThe non‐eosinophilic phenotype of asthma (NEA) is associated with chronic airway inflammation and airway neutrophilia. An accumulation of apoptotic airway epithelial cells, if not efficiently cleared by efferocytosis, can undergo secondary necrosis, with the potential for inflammation of surrounding tissues.
Simpson, Jodie L. +7 more
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Granzyme B Disrupts Epithelial Barrier Function
The FASEB Journal, 2016The epithelium functions as a barrier to the external environment, which is maintained in large part by cell junctions. Age‐related and chronic inflammatory conditions of the skin result in a loss of epithelial barrier integrity through the degradation of cell adhesion proteins.
Stephanie Santacruz +2 more
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Granzyme B in aging and age-related pathologies
Trends in Molecular MedicineAging is a major risk factor for pathologies that manifest later in life. Much attention is devoted towards elucidating how prolonged environmental exposures and inflammation promote biological (accelerated) tissue aging. Granzymes, a family of serine proteases, are increasingly recognized for their emerging roles in biological aging and disease ...
Katlyn C. Richardson +4 more
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Cytotoxic granzyme C–expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity
Science Immunology, 2022Briana Nixon, Chun Chou, Chirag Krishna
exaly
In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET
ACS Central Science, 2021Ning Zhao, Conner Bardine, Yung-Hua Wang
exaly
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
Science, 2020Zhiwei Zhou, Huabin He, Yupeng Wang
exaly