Results 111 to 120 of about 3,066,756 (267)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Distance antimagic labeling of circulant graphs

AIMS Mathematics
A distance antimagic labeling of graph $ G = (V, E) $ of order $ n $ is a bijection $ f:V(G)\rightarrow \{1, 2, \ldots, n\} $ with the property that any two distinct vertices $ x $ and $ y $ satisfy $ \omega(x)\ne\omega(y) $, where $ \omega(x) $ denotes ...
Syafrizal Sy , Rinovia Simanjuntak, Tamaro Nadeak, Kiki Ariyanti Sugeng , Tulus Tulus   +4 more
doaj   +1 more source

Using a High-Dimensional Graph of Semantic Space to Model Relationships among Words

Frontiers in Psychology, 2014
The GOLD model (Graph Of Language Distribution) is a network model constructed based on co-occurrence in a large corpus of natural language that may be used to explore what information may be present in a graph-structured model of language, and what ...
Alice F Jackson, Donald J Bolger
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

The analysis of the RBL-STEM application in improving student financial literacy in controlling consumptive behavior

Heliyon
This study aims to analyze the application of the RBL-STEM learning model in improving students' financial literacy to control their consumptive behavior.
Sumarno, Gimin, Eddy Noviana, Dafik, Zainur Rasyid Ridlo, Indah Lutfiyatul Mursyidah   +5 more
doaj  

On the Wiener Complexity and the Wiener Index of Fullerene Graphs

Mathematics, 2019
Fullerenes are molecules that can be presented in the form of cage-like polyhedra, consisting only of carbon atoms. Fullerene graphs are mathematical models of fullerene molecules.
Andrey A. Dobrynin, Andrei Yu Vesnin
doaj   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Data Mining Group [PDF]

Informatio
Graph Databases, Information Management, Panos Parchas   +2 more
core  

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Graph Neural Networks for Graph Drawing

IEEE Transactions on Neural Networks and Learning Systems
Accepted for publication in IEEE Transaction of Neural Networks and Learning Systems (TNNLS) 2022, Special Issue on Deep Neural Networks for Graphs: Theory, Models, Algorithms and ...
Matteo Tiezzi, Gabriele Ciravegna, Marco Gori   +2 more
openaire   +7 more sources