Results 121 to 130 of about 250,057 (298)

QuateXelero : an accelerated exact network motif detection algorithm

, 2013
Finding motifs in biological, social, technological, and other types of networks has become a widespread method to gain more knowledge about these networks’ structure and function.
Dichter, Norbert, Norbert Dichter, Koch, Ina, Khakabimamaghani, Sahand, Iman Sharafuddin, Sharafuddin, Iman, Masoudi-Nejad, Ali, Ina Koch, Ali Masoudi-Nejad, Sahand Khakabimamaghani   +9 more
core   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Unsupervised Graph Structure Learning Based on Optimal Graph Topology Modeling and Adaptive Data Augmentation

Graph neural networks (GNNs) are effective for structured data analysis but face reduced learning accuracy due to noisy connections and the necessity for explicit graph structures and labels.
Wenyan Liu, Jing Liu, Qin Zhao, Dongdong An, Zongxu Pan   +4 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

From observed transitions to hidden paths in Markov networks

Physical Review Research
The number of observable degrees of freedom is typically limited in experiments. Here we consider discrete Markov networks in which an observer has access to a few visible transitions and the waiting times between these transitions.
Alexander M. Maier, Udo Seifert, Jann van der Meer   +2 more
doaj   +1 more source

KOSMOS: Ontology-Based Knowledge Graph Scaffolding for Medical Documentation Generation

Information
We investigate whether an ontology-typed knowledge graph (KG) can improve SOAP note generation from clinician–patient encounter transcripts by serving as a structured intermediate representation that organizes clinically salient content while preserving ...
Ryan Henry, Jiaqi Gong
doaj   +1 more source

Enhanced Graph Structure Representation for Unsupervised Heterogeneous Change Detection

Heterogeneous change detection (CD) is widely applied in various fields such as urban planning, environmental monitoring, and disaster management. It enhances the accuracy and comprehensiveness of surface change monitoring by integrating multi-sensor ...
Te Han, Huihui Feng, Bin Zou, Fangyan Zhang, Xin Yang, Yuqi Tang   +5 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Semantic units: organizing knowledge graphs into semantically meaningful units of representation

Journal of Biomedical Semantics
Background In today’s landscape of data management, the importance of knowledge graphs and ontologies is escalating as critical mechanisms aligned with the FAIR Guiding Principles—ensuring data and metadata are Findable, Accessible, Interoperable, and ...
Lars Vogt, Tobias Kuhn, Robert Hoehndorf
doaj   +1 more source