Results 131 to 140 of about 250,057 (298)

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

A New Method for Assessing the Resiliency of Large, Complex Networks [PDF]

Designing resilient and reliable networks is a principle concern of planners and private firms. Traffic congestion whether recurring or as the result of some aperiodic event is extremely costly. This paper describes an alternative process and a model for
Sean P Gorman, Laurie A Schintler, Roger R Stough, Rajendra G Kulkarni   +3 more
core  

MSP: Multiple Sub-graph Query Processing using Structure-based Graph Partitioning Strategy and Map-Reduce

, 2019
In a distributed environment, the volume of graph database increases quickly because graphs emerge from several autonomous sources. Sub-graph query processing is a challenging problem in distributed environment.
Shaik Fathimabi, R.B.V. Subramanyam, D.V.L.N. Somayajulu   +2 more
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Celcomen: spatial causal disentanglement for single-cell and tissue perturbation modeling

Nature Communications
Celcomen leverages a mathematical causality framework to disentangle intra- and inter-cellular gene regulation programs in spatial transcriptomics data through a generative graph neural network.
Stathis Megas, Daniel G. Chen, Krzysztof Polanski, Hesam Asadollahzadeh, Moshe Eliasof, Carola-Bibiane Schönlieb, Sarah A. Teichmann   +6 more
doaj   +1 more source

Topological Modelling in Public Procurement and Platform Economies: An Interdisciplinary Legal–Economic Framework

International Journal of Topology
This article develops an interdisciplinary framework that applies topological and graph-theoretical methods to public procurement markets and digital platform economies.
Jitka Matějková
doaj   +1 more source

A Study On The Average Information Ratio Of Perfect Secret-Sharing Schemes For Access Structures Based On Bipartite Graphs

, 2012
{"references": ["A. Beimel and N. Livne, On matroids and non-ideal secret sharing, in: Proceedings of the third theory of cryptography conference, LNCS, 3876 (2006), 482-501.", "G. R. Blakley, Safeguarding cryptographic keys, in \"Proceedings of\nthe National Computer Conference, 1979\", American Federation of Information Processing Societies ...
openaire   +2 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source