Results 191 to 200 of about 117,917 (289)

Integrating Multi-Source Directed Gene Networks and Multi-Omics Data to Identify Cancer Driver Genes Based on Graph Neural Networks. [PDF]

Int J Mol Sci
Jiang Y, Liu Y, Qi R, Li S, Zhang T.
europepmc   +1 more source

Analysis of Air Transport Network Based on Network Theory and Graph Database

Assia Kamal-Idrissi
openalex   +1 more source

IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals

Advanced Science, EarlyView.
Spermatogonial stem cells (SSCs) provide critical support to spermatogenesis. Here, the author established Il1r2 as a sorting marker for SSCs, with which further insights into the SSC heterogeneity and dynamic features can be obtained. They also confirmed findings in both mouse and human, thus validating IL1R2 as the surface marker for isolating and ...
Pengyu Li, Zexuan Zhang, Zihan Xie, Cheng Jin, Zhipeng Wang, Changwei Yuan, Jun Zhu, Jielin Tang, Mengzhen Li, Dingfeng Zou, Xinyu Mang, Jun Liu, Dingyao Chen, Qi Geng, Yan Lu, Ning Zhang, Shiying Miao, Jing Peng, Kai Li, Wei Song   +19 more
wiley   +1 more source

BRENDA in 2026: a Global Core Biodata Resource for functional enzyme and metabolic data within the DSMZ Digital Diversity. [PDF]

Nucleic Acids Res
Hauenstein J, Jeske L, Jäde A, Krull M, Dümmer K, Koblitz J, Tietz A, Jahn D, Reimer LC, Bunk B.   +9 more
europepmc   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Representative Random Sampling of Chemical Space. [PDF]

J Chem Theory Comput
Monterrubio-Chanca DJ, von Rudorff GF.
europepmc   +1 more source

Direct Mappings between RDF and Property Graph Databases. [PDF]

, 2019
Harsh Thakkar, Renzo Angles, Dominik Tomaszuk, Jens Lehmann   +3 more
openalex  

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Artificial Intelligence to Guide Repurposing of Drugs. [PDF]

Annu Rev Med
Fu Z, Yang Y, Chung MK, Cheng F.
europepmc   +1 more source

An efficient graph community clustering and ranking-based cryptographic privacy preserving framework on large social databases

M. Shamila, G. Rekha, K. Vinuthna Reddy
openalex   +1 more source