Results 81 to 90 of about 845,204 (303)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Frontiers in Genetics, 2021 Protein–protein interaction (PPI) is the basis of the whole molecular mechanisms of living cells. Although traditional experiments are able to detect PPIs accurately, they often encounter high cost and require more time.
Xiao-Rui Su +15 more
doaj +1 more source
On embedding a cycle in a plane graph [PDF]
Discrete Mathematics, 2006 The problem of drawing a non-simple cycle as a non-intersecting closed curve into a planar graph drawn in the plane with the vertices represented as circles and the edges represented as thin stripes is considered. The problem is shown to have an interpretation in the \textit{clustered planarity}.
Pier Francesco Cortese +3 more
openaire +5 more sources
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Graph Simultaneous Embedding Tool, GraphSET
, 2009 Problems in simultaneous graph drawing involve the layout of several graphs on a shared vertex set. This paper describes a Graph Simultaneous Embedding Tool, GraphSET, designed to allow the investigation of a wide range of embedding problems.
Alejandro Estrella-Balderrama +5 more
core +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Journal of Combinatorial Theory, Series B, 1990 Let G be a graph of small maximum degree, which is contained in a chordal graph of small clique number. Is G then contained in a chordal graph of small maximum degree as well? This extremal problem arises from the following: suppose we seek a binary tree T and an injective mapping from V(G) to V(T) (and which sends edges of G to paths in T) so that we ...
openaire +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Patch alignment for graph embedding
, 2012 © Springer Science+Business Media New York 2013. Dozens of manifold learning-based dimensionality reduction algorithms have been proposed in the literature.
Dacheng Tao +5 more
core +1 more source