Results 91 to 100 of about 9,569,640 (309)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Energy, Laplacian energy of double graphs and new families of equienergetic graphs [PDF]

open access: yes, 2013
For a graph $G$ with vertex set $V(G)=\{v_1, v_2, \cdots, v_n\}$, the extended double cover $G^*$ is a bipartite graph with bipartition (X, Y), $X=\{x_1, x_2, \cdots, x_n\}$ and $Y=\{y_1, y_2, \cdots, y_n\}$, where two vertices $x_i$ and $y_j$ are ...
A Ganie, Hilal, S. Pirzada
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Some degree-based topological indices and (normalized Laplacian) energy of graphs [PDF]

open access: yesDiscrete Mathematics Letters, 2022
Zimo Yan, Xie Zheng, Jianping Li
doaj   +1 more source

Modeling Chinese Traditional Cultural Resonance in College Ethnic Instrumental Music Classroom Teaching using Energy driven Bipolar Interval-Valued Neutrosophic Graph [PDF]

open access: yesNeutrosophic Sets and Systems
In this work, we present a novel theoretical Neutrosophic framework, termed Energy-driven Bipolar Interval-Valued Neutrosophic Graphs (BIVNGs), modeling cultural perception dynamics in college ethnic instrumental music education through integrating ...
Yanhui Li
doaj   +1 more source

Lifted Worm Algorithm for the Ising Model

open access: yes, 2017
We design an irreversible worm algorithm for the zero-field ferromagnetic Ising model by using the lifting technique. We study the dynamic critical behavior of an energy estimator on both the complete graph and toroidal grids, and compare our findings ...
Deng, Youjin   +5 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Region graph partition function expansion and approximate free energy landscapes: Theory and some numerical results

open access: yes, 2012
Graphical models for finite-dimensional spin glasses and real-world combinatorial optimization and satisfaction problems usually have an abundant number of short loops.
A. Braunstein   +50 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

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