Results 81 to 90 of about 9,569,640 (309)
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
An algorithm to prescribe the configuration of a finite graph [PDF]
, 2010 We provide algorithms involving edge slides, for a connected simple graph to evolve in a finite number of steps to another connected simple graph in a prescribed configuration, and for the regularization of such a graph by the minimization of an ...
Baird, Paul, Tiba, Marius
core
Geometrogenesis under Quantum Graphity: problems with the ripening Universe
, 2015 Quantum Graphity (QG) is a model of emergent geometry in which space is represented by a dynamical graph. The graph evolves under the action of a Hamiltonian from a high-energy pre-geometric state to a low-energy state in which geometry emerges as a ...
Greentree, Andrew D. +1 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Method for Measuring Resilience of Complex Systems Using Network Theory and Graph Energy
IEEE Open Journal of Systems EngineeringBecause of societies’ dependence on systems that have increasing interconnectedness, governments and industries have an increasing interest in managing the resilience of these systems and the risks associated with their disruption or failure.
Christine M. Edwards +3 more
doaj +1 more source
Energy Minimization of Discrete Protein Titration State Models Using Graph Theory
, 2016 There are several applications in computational biophysics which require the optimization of discrete interacting states; e.g., amino acid titration states, ligand oxidation states, or discrete rotamer angles. Such optimization can be very time-consuming
Baker, Nathan A. +4 more
core +2 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Energy Models for Graph Clustering
Journal of Graph Algorithms and Applications, 2007 Summary: The cluster structure of many real-world graphs is of great interest, as the clusters may correspond e.g. to communities in social networks or to cohesive modules in software systems. Layouts can naturally represent the cluster structure of graphs by grouping densely connected nodes and separating sparsely connected nodes.
openaire +1 more source