Results 81 to 90 of about 942,096 (280)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Twenty Years of Entropy Research: A Bibliometric Overview

, 2019
Entropy, founded in 1999, is an emerging international journal in the field of entropy and information studies. In the year of 2018, the journal enjoyed its 20th anniversary, and therefore, it is quite reasonable and meaningful to conduct a retrospective
Yuxiu Zhao, Qi Wang, Jian Zhou, Weishu Li   +3 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Data Graph Formulation as the Minimum-Weight Maximum-Entropy Problem

, 2015
Consider a point-set coming from an object which was sampled using a digital sensor (depth range, camera, etc). We are interested in finding a graph that would represent that point-set according to some properties. Such a representation would allow us to
Walter G. Kropatsch, de Sousa, Samuel, Kropatsch, Walter G., Samuel de Sousa   +3 more
core   +1 more source

Degree-based Topological Characterization and Graph Energy Prediction of Silicon Carbide Network Si2C3-I[k, l] via Double Graph Operator

Scientific Annals of Computer Science
This study presents the precise formulation of the Nirmala index and the first and second inverse Nirmala indices for the double graph of the silicon carbide network Si2C3-I[k, l], using its M-polynomial.
U. Vijaya Chandra Kumar, H. M. Nagesh, M. B. Madhusudana Reddy   +2 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Prediction of $$\pi$$ -electronic energy and physical properties of benzenoid hydrocarbons using domination degree based entropies

Scientific Reports
This study introduces a novel approach to calculating graph entropies using topological indices, inspired by Shannon’s entropy concept. These entropies, as information-theoretic measures, are applied to evaluate the structural properties of chemical ...
Geethu Kuriachan, A. Parthiban
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Handling Missing Data via Max-Entropy Regularized Graph Autoencoder

, 2023
Graph neural networks (GNNs) are popular weapons for modeling relational data. Existing GNNs are not specified for attribute-incomplete graphs, making missing attribute imputation a burning issue.
Tang, Jianheng, Zhao, Peilin, Gao, Ziqi, Tsung, Fugee, Li, Jia, Niu, Yifan, Li, Lanqing, Xu, Tingyang, Cheng, Jiashun   +8 more
core   +1 more source