Results 91 to 100 of about 168,763 (311)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Algorithmic graph minor theory: Improved grid minor bounds and wagner’s contraction
, 2006 . We explore the three main avenues of research still unsolved in the algorithmic graph-minor theory literature, which all stem from a key min-max relation between the treewidth of a graph and its largest grid minor.
Ken-ichi Kawarabayashi +2 more
core +1 more source
BMC Ophthalmology, 2019 Background Accurate measurement and reconstruction of orbital soft tissue is important to diagnosis and treatment of orbital diseases. This study applied an interactive graph cut method to orbital soft tissue precise segmentation and calculation in ...
Qingyao Ning +6 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
On the characterization of rectangular duals [PDF]
Notes on Number Theory and Discrete MathematicsA rectangular partition is a partition of a rectangle into a finite number of rectangles. A rectangular partition is generic if no four of its rectangles meet at the same point.
Vinod Kumar, Krishnendra Shekhawat
doaj +1 more source
Logical properties of random graphs from small addable classes [PDF]
Logical Methods in Computer Science, 2019 We establish zero-one laws and convergence laws for monadic second-order logic (MSO) (and, a fortiori, first-order logic) on a number of interesting graph classes.
Anuj Dawar, Eryk Kopczyński
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Graph minors. V. Excluding a planar graph
Journal of Combinatorial Theory, Series B, 1986 [For part I see the authors' paper ibid. 35, 39-61 (1983; Zbl 0521.05062), for part III see their paper ibid. 36, 49-64 (1984; Zbl 0548.05025), for part VI see ibid., 115-138 (1986; Zbl 0598.05042). See also their survey paper in Surveys in Combinatorics 1985, Pap. 10th Br. Combin. Conf., Glasgow/Scotl. 1985, Lond. Math. Soc. Lect. Note Ser.
Neil Robertson 0001, Paul D. Seymour
openaire +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source