Results 81 to 90 of about 168,763 (311)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

The graph minor theorem in topological combinatorics

open access: yes, 2023
We study a variety of natural constructions from topological combinatorics, including matching complexes as well as other graph complexes, from the perspective of the graph minor category of \parencite{MiProRa}.
Miyata, Dane, Ramos, Eric
core  

Strong Edge Coloring of K4(t)-Minor Free Graphs

open access: yesAxioms, 2023
A strong edge coloring of a graph G is a proper coloring of edges in G such that any two edges of distance at most 2 are colored with distinct colors. The strong chromatic index χs′(G) is the smallest integer l such that G admits a strong edge coloring ...
Huixin Yin, Miaomiao Han, Murong Xu
doaj   +1 more source

Cliques in Graphs Excluding a Complete Graph Minor [PDF]

open access: yesThe Electronic Journal of Combinatorics, 2016
This paper considers the following question: What is the maximum number of $k$-cliques in an $n$-vertex graph with no $K_t$-minor? This question generalises the extremal function for $K_t$-minors, which corresponds to the $k=2$ case. The exact answer is given for $t\leq 9$ and all values of $k$.
openaire   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

The Graph Minor Algorithm with Parity Conditions

open access: yes, 2011
We generalize the seminal Graph Minor algorithm of Robertson and Seymour to the parity version. We give polynomial time algorithms for the following problems: 1) the parity H-minor (Odd K k-minor) containment problem, 2) the disjoint paths problem with k
Paul Wollan   +4 more
core   +1 more source

Quantum query complexity of minor-closed graph properties [PDF]

open access: yes, 2011
We study the quantum query complexity of minor-closed graph properties, which include such problems as determining whether an $n$-vertex graph is planar, is a forest, or does not contain a path of a given length. We show that most minor-closed properties
Andrew M. Childs   +3 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Entire choosability of near-outerplane graphs

open access: yes, 2008
It is proved that if G is a plane embedding of a K4-minor-free graph with maximum degree Δ, then G is entirely 7-choosable if Δ≤4 and G is entirely (Δ+ 2)-choosable if Δ≥ 5; that is, if every vertex, edge and face of G is given a list of max{7,Δ+2 ...
Timothy J. Hetherington   +2 more
core   +1 more source

Counting Homomorphisms to K4-minor-free Graphs, modulo 2

open access: yes, 2021
We study the problem of computing the parity of the number of homomorphisms from an input graph G to a fixed graph H. Faben and Jerrum [ToC'15] introduced an explicit criterion on the graph H and conjectured that, if satisfied, the problem is solvable ...
Stanislav Živný (17432607)   +3 more
core   +1 more source

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