Results 91 to 100 of about 2,474,612 (263)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

BASIL: Binary Anchor-Based Smart Indoor Localization

Tsinghua Science and Technology
Indoor localization has been challenging research due to the invalidity of the global navigation satellite system in indoor scenarios. Recent advances in ambient assistive living have shown great power in detecting and locating persons living in their ...
Zhe Yang, Yanjun Li, Yufan Zhang, Yun Pan, Chung Shue Chen, Yi-hua Zhu   +5 more
doaj   +1 more source

Optimal K-secure graphs

Discrete Applied Mathematics, 1980
AbstractWe wish to design a resistance movement in such a way that k subversions and the resulting betrayals do not totally destroy our network. Such graphs will be called k-secure. Subject to this restriction we determine which graphs minimize the expected number of betrayals.
Georg Gunther, Bert L. Hartnell
openaire   +2 more sources

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Unified Semantic Reasoning and Planning for Autonomous Driving

Sensors
The conventional autonomy stack layers separate representations, leaving a vertical gap between high-level semantic reasoning and low-level trajectory generation.
Ye-Chan An, Jun-Hyeon Choi, Jeong-Won Pyo, Sang-Hyeon Bae, Tae-Yong Kuc   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Advances in Graph Neural Networks for Combinatorial Optimization Problems [PDF]

Jisuanji kexue yu tansuo
Combinatorial optimization, as an important branch of mathematical optimization, focuses on finding optimal solution within a finite discrete solution space.
ZHU Ye, DING Cangfeng, CAO Bohao, CHEN Kexin
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A Study on Graph Optimization Method for GNSS/IMU Integrated Navigation System Based on Virtual Constraints

Sensors
In GNSS/IMU integrated navigation systems, factors like satellite occlusion and non-line-of-sight can degrade satellite positioning accuracy, thereby impacting overall navigation system results.
Haiyang Qiu, Yun Zhao, Hui Wang, Lei Wang   +3 more
doaj   +1 more source