Results 131 to 140 of about 2,474,612 (263)

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

The h-Hop Dominating Subnetwork Problem: Variants, Structural Properties, and Exact Solution Approaches

Mathematics
This paper introduces the h-hop dominating subnetwork problem (HSDP), a graph-optimization problem that jointly selects a prescribed number of operational vertices, determines the dominant vertices within the selected set, and assigns each selected ...
Pablo Adasme, Gustavo Alcántara
doaj   +1 more source

Competition or cooperation in a hub and spoke-shipping network: the case of the North Adriatic container terminals

Transport, 2018
This article examines the problem of the competition or cooperation of the container terminals in the North Adriatic hub and spoke system with respect to the leadership position of the ship owners, which defines the flow of containers.
Danijela Tuljak-Suban
doaj   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Subjective Cognitive Concerns and Cognitive Trajectories in Parkinson's Disease: Biomarker Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the relationship of subjective cognitive concerns (SCC) with biomarkers of Alzheimer's disease (AD), neurodegeneration, and Parkinson's disease (PD) and domain‐specific cognitive trajectories among cognitively unimpaired persons with de novo PD. Method Cognitively unimpaired participants with SCC (n = 294) and without SCC (
Francesca V. Lopez, Fareshte Erani, Katherine J. Bangen, David G. Coughlin, Douglas Galasko, Kelsey R. Thomas   +5 more
wiley   +1 more source

RC-SLAM: Road Constrained Stereo Visual SLAM System Based on Graph Optimization

Sensors
Intelligent vehicles are constrained by road, resulting in a disparity between the assumed six degrees of freedom (DoF) motion within the Visual Simultaneous Localization and Mapping (SLAM) system and the approximate planar motion of vehicles in local ...
Yuan Zhu, Hao An, Huaide Wang, Ruidong Xu, Mingzhi Wu, Ke Lu   +5 more
doaj   +1 more source

Entropy-Guided Graph Clustering via Rényi Optimization

Graph clustering is a fundamental task in network analysis, with applications ranging from community detection to protein complex identification. While Graph Neural Networks (GNNs) have shown promising results in this domain, they often struggle to ...
Begga, Ahmed, Lozano, Miguel Angel, Beretta, Guglielmo, Pelillo, Marcello, Escolano, Francisco, Vascon, Sebastiano   +5 more
core   +1 more source

Optimizing Hydroxychloroquine Blood Levels and Long‐Term Hydroxychloroquine Intake Could Lower Atherosclerotic Cardiovascular Disease Risk and Prevent Polypharmacy in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is the cornerstone of systemic lupus erythematosus (SLE) management with benefits extending beyond SLE control, including protection against atherosclerotic cardiovascular disease (ASCVD). Although HCQ blood levels reflect recent exposure and long‐term intake reflects medication adherence, the impact of longitudinal ...
Shivani Garg, Murray Urowitz, Charlie Dentz, Niriti Adhikari, Fauzia Hollnagel, Nathalie Costedoat‐Chalumeau   +5 more
wiley   +1 more source

Graph optimization approach to range-based localization

, 2020
In this article, we propose a general graph optimization-based framework for localization, which can accommodate different types of measurements with varying measurement time intervals. Special emphasis will be on range-based localization.
Fang, Xu, Wang, Chen, Xie, Lihua, Nguyen, Thien-Minh   +3 more
core   +1 more source

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objective We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. Methods We enrolled patients within 3 months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry,
Bashayer Alnuaimi, Roberta A. Berard, Jean‐Philippe Proulx‐Gauthier, Heinrike Schmeling, Michelle Batthish, Gilles Boire, Adam M. Huber, Dax G. Rumsey, Jaime Guzman, Gaëlle Chédeville, The CAPRI registry Investigators   +10 more
wiley   +1 more source